Gadobenate dimeglumine

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

This medication can harm the kidneys in certain people, and this effect may be increased if you also use other medicines harmful to the kidneys. Many other drugs (including some over-the-counter medicines) can harm your kidneys. You may need dose adjustments or special tests if you have recently used any of these medications, such as:

• lithium (Eskalith, Lithobid);
• methotrexate (Rheumatrex, Trexall);
• pain or arthritis medicines such as aspirin (Anacin, Excedrin), acetaminophen (Tylenol), ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn, Naprelan, Treximet), celecoxib (Celebrex), diclofenac (Arthrotec, Cambia, Cataflam, Voltaren, Flector Patch, Pennsaid, Solareze), indomethacin (Indocin), meloxicam (Mobic), and others;
• medicines used to treat ulcerative colitis, such as mesalamine (Pentasa) or sulfasalazine (Azulfidine);
• medicines used to prevent organ transplant rejection, such as cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune) or tacrolimus (Prograf);
• IV antibiotics such as amphotericin B (Amphotec, AmBisome, Abelcet), amikacin (Amikin), bacitracin (Baci IM), capreomycin (Capastat), gentamicin (Garamycin), kanamycin (Kantrex), streptomycin, or vancomycin (Vancocin, Vancoled);
• antiviral medicines such as acyclovir (Zovirax), adefovir (Hepsera), cidofovir (Vistide), foscarnet (Foscavir), ganciclovir (Cytovene), valacyclovir (Valtrex), or valganciclovir (Valcyte); or
• cancer medicine such as aldesleukin (Proleukin), carmustine (BiCNU, Gliadel), cisplatin (Platinol), ifosfamide (Ifex), oxaliplatin (Eloxatin), streptozocin (Zanosar), or tretinoin (Vesanoid).

There may be other drugs that can affect gadobenate dimeglumine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Gadobenate dimeglumine is injected into a vein through an IV. You will receive this injection in a clinic or hospital setting during your MRI.

Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when the medicine is injected.

Your doctor or other healthcare provider may want to watch you for a short time after your test is over. This is to make sure you do not have any unwanted side effects or delayed reactions.

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

CNS lesions (MRI): IV: 0.1 mmol/kg (0.2 mL/kg); may begin imaging immediately after administration

Renal or aorto-ilio-femoral vasculature imaging (MRA): IV: 0.1 mmol/kg (0.2 mL/kg); may begin imaging immediately after administration (calculate scan delay with test bolus [1-2 mL] or with automatic detection technique)

Refer to adult dosing.

CNS lesions: IV: Children ≥2 years and Adolescents: Refer to adult dosing.

Visually inspect prior to use; do not use if discolored or if particulate matter present. Pharmacy bulk package vial should only be entered once (using a suitable transfer device). Do not mix with other medications, including parenteral nutrition.

May cause transient increase in serum ferritin, urine zinc (with renal disease), or bilirubin (with hepatic metabolic disorders)

1% to 10%:

Central nervous system: Feeling hot (1%), headache (1%)

Gastrointestinal: Nausea (1%), vomiting (children: 1%)

Local: Injection site reaction (1%)

<1% (Limited to important or life-threatening): Abdominal pain, abnormal alanine aminotransferase (nonspecific changes), abnormal aspartate transaminase (nonspecific changes), altered sense of smell, anaphylactoid reaction, anaphylaxis, basophilia, chest pain, chills, diarrhea, dizziness, dysgeusia, dyspnea, ECG abnormality (including PR, QRS, QT, and ST-T segment changes), edema (eye edema, facial edema, lip edema, tongue edema), first degree atrioventricular block, hyperhidrosis, hypersensitivity reaction, laryngospasm, loss of consciousness, malaise, myalgia, nasal congestion, necrotizing pancreatitis (acute), ocular hyperemia, oral paresthesia, pulmonary edema, pruritus, seizure, shock, skin rash, sneezing, tremor, urticaria, visual disturbance, wheezing, xerostomia