Gadoteridol

Mechanism of Action

Paramagnetic agent; exposure to external magnetic field in gadopentetate may induce a large magnetic field. The local magnetism may change proton density and spin characteristics, which it is then detected by the imaging device

Pharmacokinetics

Half-Life: 1.5 hr

Vd: 204 mL/kg

Excretion: Urine (~94%)

Gadoteridol is part of the drug class:

• Paramagnetic contrast media

Take gadoteridol exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

The Gadoteridol dose your doctor recommends will be based on the following (use any or all that apply):

• the condition being treated
• other medical conditions you have
• other medications you are taking
• how you respond to this medication
• your weight
• your height
• your age
• your gender

Gadoteridol is available in the following doses:

• Gadoteridol 279.3 Mg/ml Injectable Solution

Gadoteridol can cause a life-threatening condition in people with advanced kidney disease. The symptoms of this condition include:

• burning, itching, swelling, scaling, and tightening or hardening of your skin;

• muscle weakness;

• joint stiffness in your arms, hands, legs, or feet;

• deep bone pain in your ribs or your hips;

• trouble moving; or

• skin redness or discoloration.

Before receiving this medication, tell your doctor if you have kidney disease or if you are on dialysis. You may not be able to receive gadoteridol. Also tell your doctor if you have recently received any contrast agents similar to gadoteridol.

To make sure you can safely receive this medication, tell your doctor if you have any of these other conditions:

• diabetes;

• high blood pressure;

• liver disease (or liver transplant);

• a heart rhythm disorder;

• anemia or other red blood cell disorder;

• a history of seizures (convulsions);

• asthma, hay fever, or a history of food or drug allergies;

• if you are over 60 years old;

• if you have ever had any type of reaction to a contrast agent; or

• if you have recently had an injury, surgery, or severe infection.

FDA pregnancy category C. It is not known whether gadoteridol will harm an unborn baby. Before you receive this medication, tell your doctor if you are pregnant.

It is not known whether gadoteridol passes into breast milk or if it could harm a nursing baby. Do not receive this medication without telling your doctor if you are breast-feeding a baby.

Since gadoteridol is used only during your MRA, you will not be on a dosing schedule.

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
• Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain.

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

The safety and efficacy of sequential and/or repeat procedures has not been studied.

Gadoteridol has been assigned to pregnancy category C by the FDA. Animal studies have revealed evidence of teratogenicity. There are no controlled data in human pregnancy. Gadoteridol is only recommended for use during pregnancy when there are no alternatives and benefit outweighs risk.

Substance Name

Gadoteridol

CAS Registry Number

112188-16-6

Drug Class

Contrast Media

Diagnostic Agents