Gadobutrol

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Gadobutrol can cause a life-threatening condition in people with advanced kidney disease. Before receiving this medicine, tell your doctor if you have kidney disease or if you are on dialysis. You may not be able to receive gadobutrol. Also tell your doctor if you have recently received any contrast agents similar to gadobutrol.

• Tell all of your health care providers that you take gadobutrol. This includes your doctors, nurses, pharmacists, and dentists.
• Very bad and sometimes deadly allergic reactions have rarely happened. Talk with your doctor.
• Kidney failure has happened with this medicine in people who already had kidney problems. Talk with the doctor.
• Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using gadobutrol while you are pregnant.
• Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

(gad oh BYOO trol)

Severe hypersensitivity reactions to gadobutrol or any component of the formulation.

Diagnostic imaging: IV:

US labeling: CNS imaging, supra-aortic or renal artery angiography: Neonates, Children, and Adolescents: Refer to adult dosing

Canadian labeling: CNS imaging/CE-MRA or renal imaging: Newborns, Infants, Children, and Adolescents: 0.1 mmol/kg (0.1 mL/kg); do not exceed recommended dose. Sequential or repeat dosing has not been studied; allow ≥7 days before considering repeat administration.

Store at 25°C (77°F); excursions are permitted between 15°C and 30°C (59°F and 86°F). If freezing occurs; bring to room temperature before use; do not use unless solution is clear, colorless to pale yellow. Discard any unused drug. Pharmacy bulk package must be discarded within 24 hours after opening in a sterile environment.

0.1 mL/kg body weight (0.1 mmol/kg) IV bolus injection
Comments: Administer manually or by power injector at a flow rate of approximately 2 mL/second. Refer to manufacturer product information to determine volume to be administered.

Use: Indicated for use with MRI to assess the presence and extent of malignant breast disease.

0.1 mL/kg body weight (0.1 mmol/kg) IV bolus injection
Comments: Administer manually or by power injector at a flow rate of approximately 2 mL/second. Refer to manufacturer product information to determine volume to be administered.

Use:
-Indicated for use with MRI to detect and visualize areas with disrupted blood brain barrier (BBB) and/or abnormal vascularity of the central nervous system.

No adjustment recommended.