Chlorpheniramine and hydrocodone

Chlorpheniramine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Hydrocodone is a narcotic cough suppressant. It affects the signals in the brain that trigger cough reflex.

Chlorpheniramine and hydrocodone is a combination medicine used to treat runny nose, sneezing, itching, watery eyes, and cough caused by allergies, the common cold, or the flu.

Chlorpheniramine and hydrocodone may also be used for purposes not listed in this medication guide.

Usual Adult Dose for Cold Symptoms:

Chlorpheniramine-hydrocodone 4 mg-5 mg/5 mL oral suspension, extended release:
10 mL orally every 12 hours not to exceed 20 mL daily.

Chlorpheniramine-hydrocodone 8 mg-10 mg/5 mL oral suspension, extended release:
5 mL orally every 12 hours not to exceed 10 mL daily.

Chlorpheniramine-hydrocodone 8 mg-10 mg oral capsule, extended release:
one capsule orally every 12 hours not to exceed 2 capsules in 24 hours.

Usual Adult Dose for Cough:

Chlorpheniramine-hydrocodone 4 mg-5 mg/5 mL oral suspension, extended release:
10 mL orally every 12 hours not to exceed 20 mL daily.

Chlorpheniramine-hydrocodone 8 mg-10 mg/5 mL oral suspension, extended release:
5 mL orally every 12 hours not to exceed 10 mL daily.

Chlorpheniramine-hydrocodone 8 mg-10 mg oral capsule, extended release:
one capsule orally every 12 hours not to exceed 2 capsules in 24 hours.

Usual Pediatric Dose for Cold Symptoms:

Chlorpheniramine-hydrocodone 4 mg-5 mg/5 mL oral suspension, extended release:
12 yrs or older: 10 mL orally every 12 hours not to exceed 20 mL daily.
6 yrs to 11 yrs: 5 mL orally every 12 hours not to exceed 10 mL daily.

Chlorpheniramine-hydrocodone 8 mg-10 mg/5 mL oral suspension, extended release:
12 yrs or older: 5 mL orally every 12 hours not to exceed 10 mL daily.
6 yrs to 11 yrs: 2.5 mL orally every 12 hours not to exceed 5 mL daily.

Chlorpheniramine-hydrocodone 8 mg-10 mg oral capsule, extended release:
12 yrs or older: one capsule orally every 12 hours not to exceed 2 capsules in 24 hours.

Chlorpheniramine-hydrocodone 4 mg-5 mg oral capsule, extended release:
6 to 11 yrs: one capsule orally every 12 hours not to exceed 2 capsules in 24 hours.

Usual Pediatric Dose for Cough:

Chlorpheniramine-hydrocodone 4 mg-5 mg/5 mL oral suspension, extended release:
12 yrs or older: 10 mL orally every 12 hours not to exceed 20 mL daily.
6 yrs to 11 yrs: 5 mL orally every 12 hours not to exceed 10 mL daily.

Chlorpheniramine-hydrocodone 8 mg-10 mg/5 mL oral suspension, extended release:
12 yrs or older: 5 mL orally every 12 hours not to exceed 10 mL daily.
6 yrs to 11 yrs: 2.5 mL orally every 12 hours not to exceed 5 mL daily.

Chlorpheniramine-hydrocodone 8 mg-10 mg oral capsule, extended release:
12 yrs or older: one capsule orally every 12 hours not to exceed 2 capsules in 24 hours.

Chlorpheniramine-hydrocodone 4 mg-5 mg oral capsule, extended release:
6 to 11 yrs: one capsule orally every 12 hours not to exceed 2 capsules in 24 hours.

Taking chlorpheniramine and hydrocodone with other drugs that make you sleepy or slow your breathing can cause dangerous side effects or death. Ask your doctor before taking a sleeping pill, narcotic pain medicine, prescription cough medicine, a muscle relaxer, or medicine for anxiety, depression, or seizures.

Tell your doctor about all your current medicines and any you start or stop using, especially:

• medicine for a stomach or intestinal disorder;

• an MAO inhibitor--isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others; or

• a sedative--Valium, diazepam, alprazolam, lorazepam, Ativan, Klonopin, Restoril, Tranxene, Versed, Xanax, and others.

This list is not complete. Other drugs may interact with chlorpheniramine and hydrocodone, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Applies to chlorpheniramine / hydrocodone: oral capsule extended release, oral liquid, oral suspension extended release

Nervous system

Nervous system side effects have included sedation, drowsiness, mental clouding, lethargy, impairment of mental performance, anxiety, fear, dysphoria, euphoria, dizziness, psychic dependence, and mood changes.[Ref]

Dermatologic

Dermatologic side effects have included rash and pruritus.[Ref]

Gastrointestinal

Gastrointestinal side effects have included nausea, vomiting, and constipation.[Ref]

Genitourinary

Genitourinary side effects have included ureteral spasm, spasm of versicle sphincters, and urinary retention.[Ref]

Respiratory

Respiratory side effects have included respiratory depression, dryness of the pharynx, and occasional tightness of the chest.[Ref]

The long-acting hydrocodone-containing cough product (marketed as Tussionex Pennkinetic Extended-Release Suspension) may produce dose-related respiratory depression by acting directly on brain stem respiratory centers. Its use of been associated with fatal respiratory depression.[Ref]

General

General side effects have included impairment of physical performance.[Ref]

Some side effects of chlorpheniramine / hydrocodone may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Chlorpheniramine-hydrocodone 4 mg-5 mg/5 mL oral suspension, extended release:
10 mL orally every 12 hours not to exceed 20 mL daily.

Chlorpheniramine-hydrocodone 8 mg-10 mg/5 mL oral suspension, extended release:
5 mL orally every 12 hours not to exceed 10 mL daily.

Chlorpheniramine-hydrocodone 8 mg-10 mg oral capsule, extended release:
one capsule orally every 12 hours not to exceed 2 capsules in 24 hours.

Chlorpheniramine-hydrocodone 4 mg-5 mg/5 mL oral suspension, extended release:
10 mL orally every 12 hours not to exceed 20 mL daily.

Chlorpheniramine-hydrocodone 8 mg-10 mg/5 mL oral suspension, extended release:
5 mL orally every 12 hours not to exceed 10 mL daily.

Chlorpheniramine-hydrocodone 8 mg-10 mg oral capsule, extended release:
one capsule orally every 12 hours not to exceed 2 capsules in 24 hours.

Chlorpheniramine-hydrocodone 4 mg-5 mg/5 mL oral suspension, extended release:
12 yrs or older: 10 mL orally every 12 hours not to exceed 20 mL daily.
6 yrs to 11 yrs: 5 mL orally every 12 hours not to exceed 10 mL daily.

Chlorpheniramine-hydrocodone 8 mg-10 mg/5 mL oral suspension, extended release:
12 yrs or older: 5 mL orally every 12 hours not to exceed 10 mL daily.
6 yrs to 11 yrs: 2.5 mL orally every 12 hours not to exceed 5 mL daily.

Chlorpheniramine-hydrocodone 8 mg-10 mg oral capsule, extended release:
12 yrs or older: one capsule orally every 12 hours not to exceed 2 capsules in 24 hours.

Chlorpheniramine-hydrocodone 4 mg-5 mg oral capsule, extended release:
6 to 11 yrs: one capsule orally every 12 hours not to exceed 2 capsules in 24 hours.

Data not available

Data not available