Chlorpheniramine, Phenylephrine, and Dextromethorphan

Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = discontinued product.

Liquid, oral:

Corfen-DM: Chlorpheniramine maleate 4 mg, phenylephrine hydrochloride 10 mg, and dextromethorphan hydrobromide 15 mg per 5 mL (473 mL [DSC]) [dye free, ethanol free, sugar free; contains propylene glycol; grape flavor]

De-Chlor DM: Chlorpheniramine maleate 2 mg, phenylephrine hydrochloride 10 mg, and dextromethorphan hydrobromide 15 mg per 5 mL (473 mL) [dye free, ethanol free, sugar free; contains propylene glycol; strawberry flavor]

Ed A-Hist DM: Chlorpheniramine maleate 4 mg, phenylephrine hydrochloride 10 mg, and dextromethorphan hydrobromide 15 mg per 5 mL (473 mL) [gluten free, sugar free; contains propylene glycol; banana flavor]

Father John's® Plus: Chlorpheniramine maleate 2 mg, phenylephrine hydrochloride 5 mg, and dextromethorphan hydrobromide 5 mg per 15 mL (118 mL) [ethanol free]

NoHist DM: Chlorpheniramine maleate 4 mg, phenylephrine hydrochloride 10 mg, and dextromethorphan hydrobromide 15 mg per 5 mL (473 mL) [dye free, ethanol free, sugar free; contains propylene glycol; grape flavor]

Norel CS: Chlorpheniramine maleate 4 mg, phenylephrine hydrochloride 10 mg, and dextromethorphan hydrobromide 12.5 mg per 5 mL (473 mL) [dye free, ethanol free, sugar free; contains propylene glycol; grape flavor]

Liquid, oral [drops]:

Cardec™ DM: Chlorpheniramine maleate 1 mg, phenylephrine hydrochloride 3.5 mg, and dextromethorphan hydrobromide 3 mg per 1 mL (30 mL) [ethanol free, gluten free, sugar free; contains propylene glycol, sodium benzoate; grape flavor]

nasohist™ DM pediatric: Chlorpheniramine maleate 1 mg, phenylephrine hydrochloride 2 mg, and dextromethorphan hydrobromide 3 mg per 1 mL (30 mL [DSC]) [dye free, ethanol free, sugar free; contains propylene glycol; orange-vanilla flavor]

Neo DM: Chlorpheniramine maleate 0.75 mg, phenylephrine hydrochloride 1.75 mg, and dextromethorphan hydrobromide 2.75 mg per 1 mL (30 mL [DSC]) [ethanol free, sugar free; contains propylene glycol; black cherry flavor]

Trigofen DM: Chlorpheniramine maleate 1 mg, phenylephrine hydrochloride 2 mg, and dextromethorphan hydrobromide 3 mg per 1 mL (30 mL [DSC]) [dye free, ethanol free, sugar free; contains propylene glycol]

Virdec DM: Chlorpheniramine maleate 1 mg, phenylephrine hydrochloride 3.5 mg, and dextromethorphan hydrobromide 3 mg per 1 mL (30 mL [DSC]) [ethanol free, gluten free, sugar free; contains propylene glycol; grape flavor]

Tablet, oral:

Ed A-Hist: Chlorpheniramine maleate 4 mg, phenylephrine hydrochloride 10 mg, and dextromethorphan hydrobromide 10 mg

Do not use to sedate or make a child sleep; with or within 14 days of stopping a monoamine oxidase inhibitor (MAO) inhibitor therapy.

Refer to adult dosing.

Note: All dosing is presented in terms of chlorpheniramine maleate, phenylephrine hydrochloride, and dextromethorphan hydrobromide.

Cough and upper respiratory symptoms: Oral: Dosing may vary by product; consult specific product labeling.

Children: 6 to 11 years:

Liquid:

Chlorpheniramine 1 mg, phenylephrine 3.5 mg, and dextromethorphan 3 mg per 1 mL: 1 mL every 4 to 6 hours (maximum: 6 mL/24 hours)

Chlorpheniramine 2 to 4 mg, phenylephrine 5 to 10 mg, and dextromethorphan 12.5 to 15 mg per 5 mL: 2.5 mL every 4 to 6 hours (maximum: 15 mL/24 hours)

Tablet: Chlorpheniramine 4 mg, phenylephrine 10 mg, and dextromethorphan 10 mg: One-half tablet every 4 hours (maximum: 3 tablets/24 hours)

Children ≥12 years: Refer to adult dosing.

There are no dosage adjustments provided in the manufacturer's labeling.

• Discuss specific use of drug and side effects with patient as it relates to treatment. (HCAHPS: During this hospital stay, were you given any medicine that you had not taken before? Before giving you any new medicine, how often did hospital staff tell you what the medicine was for? How often did hospital staff describe possible side effects in a way you could understand?)

• Patient may experience dizziness, anxiety, insomnia, or fatigue (HCAHPS).

• Educate patient about signs of a significant reaction (eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat). Note: This is not a comprehensive list of all side effects. Patient should consult prescriber for additional questions.

Intended Use and Disclaimer: Should not be printed and given to patients. This information is intended to serve as a concise initial reference for healthcare professionals to use when discussing medications with a patient. You must ultimately rely on your own discretion, experience and judgment in diagnosing, treating and advising patients.