Chlorpromazine Hydrochloride
Name: Chlorpromazine Hydrochloride
- Chlorpromazine Hydrochloride chlorpromazine hydrochloride dosage
- Chlorpromazine Hydrochloride 1 mg
- Chlorpromazine Hydrochloride dosage
- Chlorpromazine Hydrochloride usual dose
- Chlorpromazine Hydrochloride tablet
- Chlorpromazine Hydrochloride drug
- Chlorpromazine Hydrochloride injection
- Chlorpromazine Hydrochloride action
- Chlorpromazine Hydrochloride effects of
- Chlorpromazine Hydrochloride adverse effects
- Chlorpromazine Hydrochloride chlorpromazine hydrochloride injection
- Chlorpromazine Hydrochloride mg
- Chlorpromazine Hydrochloride chlorpromazine hydrochloride tablet
- Chlorpromazine Hydrochloride names
Uses for Chlorpromazine Hydrochloride
Psychotic Disorders
Symptomatic management of psychotic disorders (i.e., schizophrenia).105 106 c d g
Nausea and Vomiting
Management of nausea and vomiting, including during surgery.105 106 c d
Preoperative Sedation
Relief of restlessness and apprehension before surgery.105 106 c
Acute Intermittent Porphyria
Treatment of acute intermittent porphyria.105 106 c d
Tetanus
Adjunct in the treatment of tetanus.105 106 c d
Bipolar Disorder
Symptomatic management of manic phase of bipolar disorder.105 106 c
Intractable Hiccups
Treatment of intractable hiccups.105 106 c d
Disruptive Behavior Disorder and Attention Deficit Hyperactivity Disorder (ADHD)
Treatment of severe behavioral problems in children marked by combativeness and/or explosive hyperexcitable behavior (out of proportion to immediate provocations).105 106 c
Short-term treatment of hyperactive children who exhibit excessive motor activity with accompanying conduct disorders manifested as impulsivity, difficulty sustaining attention, aggression, mood lability, and/or poor frustration tolerance.105 106 c
Chlorpromazine Hydrochloride Dosage and Administration
General
-
Adjust dosage carefully according to individual requirements and response; use the lowest possible effective dosage.105 106 c
-
Periodically evaluate patients receiving long-term therapy to determine whether maintenance dosage can be decreased or drug therapy discontinued.105 106 c (See Tardive Dyskinesia under Cautions.)
Psychotic Disorders
-
For symptomatic relief of psychotic disorders, initial therapeutic response to antipsychotic therapy usually occurs within 1–4 weeks and optimum therapeutic response occurs within 6 months or longer.105 106 d g
-
For prompt control of severe psychotic symptoms, administer IM; after symptoms are controlled, oral therapy should replace parenteral therapy.105 106 c d
-
Once optimum dosage is achieved, continue this dosage for 2 weeks, then gradually reduce to lowest possible effective dosage.105 106 c
Administration
Administer orally, by deep IM or direct IV injection, or by IV infusion.105 106 c
Sub-Q administration not recommended because of local irritation.106 c
Avoid skin and clothing contact with chlorpromazine hydrochloride injection, since contact dermatitis has occurred rarely.106 c
Reserve parenteral therapy for recumbent patients;106 c however, if cautions are taken to avoid orthostatic hypotension (i.e., patient remains recumbent for ≥30 minutes after injection), acutely agitated ambulatory patients may receive the drug IM.106 c
IV Administration
For solution and drug compatibility information, see Compatibility under Stability.
Direct IV injection for use only during surgery to control nausea and vomiting and in the adjunctive treatment of tetanus.106 c
IV infusion is intended only for use in adjunctive treatment of intractable hiccups in adults.106 c
Avoid IV administration of undiluted drug.106 c
DilutionFor direct IV injection, dilute with 0.9% sodium chloride injection to a concentration not exceeding 1 mg/mL.106 c
For IV infusion, add injection to 500–1000 mL of 0.9% sodium chloride.106 c
Rate of AdministrationChildren: For direct IV injection, administer diluted solution at a rate of 0.5 mg/minute.106 c
Adults: For direct IV injection, administer diluted solution at a rate of 1 mg/minute.106 c For IV infusion, administer diluted solution slowly.106 c
IM Administration
Inject slowly, deep into a large muscle mass such as the upper outer quadrant of the gluteus maximus.106 c
DilutionIf irritation at IM injection site occurs, may dilute with 0.9% sodium chloride injection or 2% procaine hydrochloride.106 c
Dosage
Available as chlorpromazine hydrochloride; dosage expressed in terms of the hydrochloride salt.105 106 c
Manufacturers state that the 100- and 200-mg tablets are intended for use in patients with severe neuropsychiatric conditions.105 c
Chlorpromazine should generally not be used in children <6 months of age unless the condition to be treated is potentially life-threatening; dosage in this age group has not been established.105 106 c
Pediatric Patients
Adolescents 13–17 years of age: No specific dosage recommendations; dosage is based on patient weight and clinician judgment.k l
Nausea and Vomiting OralChildren 6 months to 12 years of age: Usually, 0.55 mg/kg every 4–6 hours as necessary.105 c Adjust dosage based on symptom severity and patient response.105 c
IMChildren 6 months to 12 years of age: Initially, 0.55 mg/kg every 6–8 hours as necessary; carefully adjust subsequent dosage based on symptom severity and patient response.106 c
Surgery Preoperative Sedation OralChildren 6 months to 12 years of age: 0.55 mg/kg administered 2–3 hours before surgery.105 c
IMChildren 6 months to 12 years of age: 0.55 mg/kg administered 1–2 hours before surgery.106 c
Nausea and Vomiting During Surgery IVChildren 6 months to 12 years of age: Fractional 1-mg doses may be given at 2-minute intervals up to a total dosage of 0.275 mg/kg;106 c may repeat fractional dosage regimen after 30 minutes if necessary and if hypotension does not occur.106 c
IMChildren 6 months to 12 years of age: 0.275 mg/kg;106 c may repeat dosage in 30 minutes if necessary and if hypotension does not occur.106 c
Tetanus IM or IVChildren 6 months to 12 years of age: 0.55 mg/kg every 6–8 hours by IM or direct IV injection.106 c
In children weighing <22.7 kg, maximum parenteral dosage is 40 mg daily.106 c In children weighing 22.7–45.5 kg, maximum parenteral dosage is ≤75 mg daily, except in severe cases.106 c
Disruptive Behavior Disorder and ADHD Outpatients Oral or IMChildren 1–12 years of age: Initially, 0.55 mg/kg orally every 4–6 hours or IM every 6–8 hours as necessary;105 106 c increase dosage gradually as required.105 106 c
Hospitalized Patients Oral or IMInitiate with low dosage as with outpatients and increase dosage gradually.105 106 c For severe behavior disorders, higher dosages (50–100 mg daily, and in older children: ≥200 mg daily) may be necessary.105 106 c There is little evidence that behavior improvement in severely disturbed, mentally retarded patients is further enhanced at dosages >500 mg daily.105 106 c
IMMaximum 40 mg daily for children <5 years (or 22.7 kg).106 c
Maximum ≤75 mg daily for children 5–12 years of age (or 22.7–45.5 kg);106 c dosage may be further increased in unmanageable patients.106 c
Adults
Psychotic DisordersUsual oral dosage during maintenance therapy is 200 mg daily; however, oral dosages up to 800 mg daily may be required in some patients.105 106 c
Outpatients with Relatively Mild Symptomatology Oral30–75 mg daily, given in 2–4 divided doses.105 c
Outpatients with More Severe Symptomatology OralInitially, 25 mg 3 times daily.105 c After 1 or 2 days, may gradually increase dosage twice weekly by 20–50 mg until symptoms are controlled.105 c
If used to replace parenteral therapy after prompt control of symptoms achieved, initiate oral therapy at 25–50 mg 3 times daily.105 106 c
IMFor prompt control of severe symptoms, 25 mg IM initially; may repeat in 1 hour if necessary.106 c After symptoms are controlled, replace parenteral therapy with oral therapy at dosage of 25–50 mg 3 times daily.105 106 c
Hospitalized Patients OralDosages of 500 mg daily are generally sufficient in most patients.105 c Dosages >2 g daily may be required in some patients; however, little therapeutic gain is achieved with dosages >1 g daily administered for extended periods.105 c
Less acutely agitated patients: Initially, 25 mg 3 times daily;105 c gradually increase subsequent dosage.105 Usually do not exceed 400 mg daily.105 c
IMIn acute schizophrenic or manic patients: Initially, 25 mg.106 c May administer an additional IM dose of 25–50 mg in 1 hour if necessary.106 c Increase subsequent dosage gradually over several days to a maximum of 400 mg every 4–6 hours in exceptionally severe cases until symptoms are controlled.106 c
Usually, patients become quiet and cooperative within 24–48 hours after therapy initiation;105 106 oral therapy can then replace parenteral therapy.106
Nausea and Vomiting Oral10–25 mg every 4–6 hours;105 c may increase dosage if necessary.105 c
IMInitially, usual dose is 25 mg.106 c If hypotension does not occur, may administer additional IM doses of 25–50 mg every 3–4 hours until symptoms subside; oral therapy should then replace parenteral therapy if necessary.106 c
Surgery Preoperative Sedation Oral25–50 mg, 2–3 hours before surgery.105 c
IM12.5–25 mg, 1–2 hours before surgery.106 c
Nausea and Vomiting During Surgery IVFractional 2-mg doses may be given IV at 2-minute intervals up to a maximum total dosage of 25 mg.106 c
IM12.5 mg; may repeat dose in 30 minutes if hypotension does not occur.106 c
Acute Intermittent Porphyria Oral25–50 mg 3 or 4 times daily.105 c Can discontinue therapy after several weeks; however, some patients may require maintenance therapy.105 c
IM25 mg 3 or 4 times daily until patient can take oral therapy.106 c
Tetanus IV25–50 mg by direct IV injection.106 c
IM25–50 mg 3 or 4 times daily, usually in conjunction with barbiturates.106 c Determine total dosage and administration frequency by patient response, starting with low dosage and increasing gradually.106
Intractable Hiccups Oral or IMInitially, 25–50 mg orally 3 or 4 times daily.105 c If symptoms persist for 2–3 days, may give 25–50 mg IM.105 106 c
IVIf hiccups persist after oral and IM therapy, may administer 25–50 mg by slow IV infusion with patient in a supine position.106 c Closely monitor BP.106 c
Prescribing Limits
Pediatric Patients
Nausea and Vomiting IMMaximum 40 mg daily for children 6 months to <5 years of age (or <22.7 kg).106 c
Maximum 75 mg daily for children 5–12 years of age (or 22.7–45.5 kg), except in severe cases.106 c
Tetanus IM or IVMaximum 40 mg daily for children <22.7 kg.106 c
Maximum ≤75 mg daily for children 22.7–45.5 kg, except in severe cases.106 c
Disruptive Behavior Disorder and ADHD Hospitalized Patients Oral or IMMaximum effective dosage not established, but there is little evidence that behavior improvement in severely disturbed mentally retarded patients is further enhanced at dosages >500 mg daily.105 106 c
IMMaximum 40 mg daily for children <5 years (or <22.7 kg).106 c
Maximum ≤75 mg daily for children 5–12 years of age (or from 22.7–45.5 kg); dosage may be further increased in unmanageable patients.106 c
Adults
Psychotic Disorders Hospitalized Patients OralLittle therapeutic gain achieved by dosages >1 g daily administered for extended periods.105 c
Less acutely agitated patients: Usually do not exceed 400 mg daily.105 c
IMMaximum IM dosage of 400 mg every 4–6 hours.106 c
Surgery Nausea and Vomiting During Surgery IVMaximum total dosage of 25 mg.106 c
Special Populations
Geriatric Patients
No specific dosage recommendations for geriatric patients, but generally select dosage at the lower end of recommended range; increase dosage more gradually and monitor closely.105 106 c d (See Geriatric Use under Cautions.)
Debilitated or Emaciated Patients
Increase dosage more gradually.105 106 c d
Cautions for Chlorpromazine Hydrochloride
Contraindications
-
Comatose states or in the presence of large amounts of CNS depressants (e.g., alcohol, barbiturates, opiates).105 106 d (See Specific Drugs and Laboratory Tests under Interactions.)
-
Known hypersensitivity to phenothiazines.105 106
Warnings/Precautions
Warnings
Shares the toxic potentials of other phenothiazines; observe the usual precautions of phenothiazine therapy.105 106 c d
Increased Mortality in Geriatric Patients with Dementia-related PsychosisIncreased risk of death with use of either conventional (first-generation) or atypical (second-generation) antipsychotics in geriatric patients with dementia-related psychosis.101 105 106 n
Antipsychotic agents, including chlorpromazine, are not approved for the treatment of dementia-related psychosis.101 105 106 n (See Increased Mortality in Geriatric Patients with Dementia-related Psychosis in Boxed Warning.)
Extrapyramidal ReactionsPossible extrapyramidal reactions.105 106 d Signs and symptoms may be similar to those accompanying certain disorders (e.g., encephalitis, Reye’s syndrome, encephalopathy, meningitis, tetanus); diagnosis of these disorders may be obscured or the disease-associated signs and symptoms may be incorrectly diagnosed as drug induced.105 106 d Avoid use in children and adolescents whose signs and symptoms suggest Reye’s syndrome.105 106
Tardive DyskinesiaTardive dyskinesia, a syndrome of potentially irreversible, involuntary dyskinetic movements, reported with use of antipsychotic agents, including chlorpromazine.105 106 d g
Reserve long-term antipsychotic treatment for patients with chronic illness known to respond to antipsychotic agents, and for whom alternative, equally effective, but potentially less harmful treatments are not available or appropriate.105 106 In patients requiring chronic treatment, use smallest dosage and shortest duration of treatment producing a satisfactory clinical response; periodically reassess need for continued therapy.105 106
APA recommends assessing patients receiving conventional antipsychotic agents for abnormal involuntary movements every 6 months; for patients at increased risk for tardive dyskinesia, assess every 3 months.g Consider discontinuance of chlorpromazine if signs and symptoms of tardive dyskinesia appear.105 106 However, some patients may require treatment despite the presence of the syndrome.105 106
Neuroleptic Malignant SyndromeNeuroleptic malignant syndrome (NMS), a potentially fatal syndrome characterized by hyperpyrexia, muscle rigidity, altered mental status, and autonomic instability, reported with antipsychotic agents, including chlorpromazine.105 106 d g
Immediately discontinue therapy and initiate supportive and symptomatic therapy if NMS occurs.105 106 Careful monitoring recommended if therapy is reinstituted following recovery; the risk that NMS can recur must be considered.105 106
Concomitant Therapy with LithiumAlthough most patients receiving lithium and an antipsychotic agent concurrently do not develop unusual adverse effects, an acute encephalopathic syndrome occasionally has occurred, especially when high serum lithium concentrations were present.105 106 d (See Specific Drugs and Laboratory Tests under Interactions.)
Cognitive and Motor ImpairmentMay impair mental and/or physical abilities, especially during the first few days of therapy; use caution with activities requiring alertness (e.g., operating vehicles or machinery).105 106 d g (See Specific Drugs and Laboratory Tests under Interactionsand see also Advice to Patients.)
Because of CNS depressant effects, use with caution in patients with chronic respiratory disorders (e.g., severe asthma, emphysema, acute respiratory tract infections), particularly in children 1–12 years of age.105 106 d
Fetal/Neonatal MorbiditySafety of use during pregnancy not established.105 106 Prolonged jaundice, extrapyramidal signs and symptoms, hyperreflexia, and hyporeflexia reported in some neonates born to women who received phenothiazines during pregnancy.105 106
Risk of extrapyramidal and/or withdrawal symptoms (e.g., agitation, hypertonia, hypotonia, tardive dyskinetic-like symptoms, tremor, somnolence, respiratory distress, feeding disorder) in neonates exposed to antipsychotic agents during the third trimester; monitor neonates exhibiting such symptoms.105 o p q Symptoms were self-limiting in some neonates but varied in severity; some infants required intensive support and prolonged hospitalization.105 o p q
Generally, use during pregnancy only when potential benefits justify possible risks to the fetus.105 106
Sensitivity Reactions
Hypersensitivity and Cross-sensitivityPossible sensitivity reactions (e.g., cholestatic jaundice, blood dyscrasias, skin reactions, anaphylactoid reactions).105 106 d Use generally not recommended in patients who have previously demonstrated a hypersensitivity reaction (e.g., blood dyscrasias, jaundice) to a phenothiazine, unless potential benefits outweigh the possible risks.105 106 d
Contact dermatitis occurs rarely following skin contact with chlorpromazine hydrochloride injection; use care to avoid skin contact with injection.106 c
PhotosensitivityPhotosensitivity may occur; avoid excessive exposure to sun during therapy.105 106 d
Sulfite SensitivitySome formulations contain sulfites, which may cause allergic-type reactions (including anaphylaxis and life-threatening or less severe asthmatic episodes) in certain susceptible individuals.106 c
General Precautions
Hematologic EffectsLeukopenia and neutropenia temporally related to antipsychotic agents, including chlorpromazine, reported during clinical trial and/or postmarketing experience.105 106 r Agranulocytosis (including fatal cases) also reported with antipsychotic agents.105 106
Possible risk factors for leukopenia and neutropenia include preexisting low WBC count and a history of drug-induced leukopenia or neutropenia.105 106 r Monitor CBC frequently during the first few months of therapy in patients with such risk factors.105 106 Discontinue chlorpromazine at the first sign of a decline in WBC count in the absence of other causative factors.105 106
Carefully monitor patients with clinically significant neutropenia for fever or other signs and symptoms of infection and treat promptly if they occur.105 106 In patients with severe neutropenia (ANC <1000/mm3), discontinue chlorpromazine and monitor WBC until recovery occurs.105 106
Nervous System EffectsPossible suppression of the cough reflex and aspiration of gastric contents.105 106 d
Possible risk of seizures; may lower seizure threshold.105 106 d Use with caution in patients with a history of seizures or EEG abnormalities or in those receiving anticonvulsant agents.105 106 d Maintain adequate anticonvulsant therapy.105 106 d Chlorpromazine does not intensify anticonvulsant action of barbiturates; dosage of anticonvulsants should not be reduced.105 d
HyperprolactinemiaMay cause elevated serum prolactin concentrations, which may persist during chronic administration and cause clinical disturbances (e.g., galactorrhea, amenorrhea, gynecomastia, impotence); chronic hyperprolactinemia associated with hypogonadism may lead to decreased bone density.105 106 d g
If contemplating chlorpromazine therapy in a patient with previously detected breast cancer, consider that approximately one-third of human breast cancers are prolactin-dependent in vitro.105 106 d g
Hepatic EffectsCholestatic jaundice or liver damage reported.105 106 d g
Perform hepatic function tests immediately in patients who develop fever accompanied by flu-like symptoms (e.g., nausea, vomiting, anorexia) during therapy; if hepatic function tests results are abnormal, discontinue drug.105 106 d g
Anticholinergic EffectsPossible anticholinergic effects (e.g., dry mouth, blurred vision, mydriasis, constipation, obstipation, nausea, adynamic ileus, atonic colon, urinary retention, decreased perspiration, and impotence).105 106 d
Use with caution in patients with glaucoma or prostatic hypertrophy.105 106 d
Cardiovascular EffectsPossible hypotension (including orthostatic hypotension), tachycardia, momentary fainting and dizziness, and ECG changes.105 106 d g
To minimize hypotension following IM administration, patient should remain in supine position under observation for ≥30 minutes.106
If hypotension occurs, place patient in Trendelenburg’s position and, if required, administer norepinephrine or phenylephrine; epinephrine or dopamine should not be used.105 106 d (See Specific Drugs and Laboratory Tests under Interactions.)
Use with caution in patients with cardiovascular disease.105 106 d
Ocular EffectsConsider possibility of pigmentary retinopathy and lenticular and corneal deposits in patients receiving prolonged therapy.105 106 d g Periodic ophthalmic examinations recommended in patients receiving prolonged phenothiazine therapy with moderate to high dosages.105 106 d g
Body Temperature RegulationPhenothiazines depress the hypothalamic mechanism for body temperature regulation; possible hyperthermia or hypothermia when exposed to temperature extremes.105 106 d g
Use with caution in patients exposed to extreme heat or cold.105 106 d
MutagenicityChromosomal aberrations in spermatocytes and abnormal sperm have been demonstrated in rodents receiving certain antipsychotic agents.105 106 d
Abrupt WithdrawalPossible gastritis, nausea and vomiting, dizziness, and tremulousness after abrupt discontinuance of high-dose therapy;105 106 d may avoid or reduce symptoms by gradual withdrawal or by continuing antiparkinsonian agents for several weeks after therapy is withdrawn.105 106 d
Other PrecautionsAntiemetic effects may mask signs of overdosage of other drugs (e.g., antineoplastic agents) or obscure cause of vomiting in various disorders (e.g., intestinal obstruction, Reye’s syndrome, brain tumor).105 106 d
Use phenothiazines with caution in debilitated patients, patients with renal or hepatic disease, and patients exposed to organophosphate insecticides.105 106 d
Use phenothiazines with caution in patients with hypocalcemia, since susceptibility to dystonic reactions may be increased.d
Specific Populations
PregnancyCategory C.e (See Fetal/Neonatal Morbidity under Cautions.)
LactationDistributed into milk.105 106 c d e i Discontinue nursing or the drug.105 106 d
Pediatric UseSafety and efficacy in children <6 months of age not established; generally, do not use unless condition to be treated is potentially life-threatening.105 106 c Do not use in conditions for which pediatric dosage not established.105 106 c
Geriatric UseGeriatric patients appear to be particularly sensitive to adverse CNS (e.g., tardive dyskinesia, parkinsonian manifestations, akathisia, sedation), anticholinergic, and cardiovascular (e.g., orthostatic hypotension) effects of antipsychotic agents.105 106 d g Possible increased risk for falls and consequent hip fractures.d
Use with caution.d (See Geriatric Patients under Dosage and Administration.)
Geriatric patients with dementia-related psychosis treated with either conventional or atypical antipsychotic agents are at an increased risk of death.101 105 106 n (See Increased Mortality in Geriatric Patients with Dementia-related Psychosis in Boxed Warning and also under Cautions.)
Common Adverse Effects
Extrapyramidal reactions (e.g., Parkinson-like symptoms, dystonia, akathisia, tardive dyskinesia), drowsiness, dizziness, skin reactions or rash, dry mouth, orthostatic hypotension, amenorrhea, galactorrhea, weight gain.105 106 c d g
Stability
Storage
Oral
TabletsTight, light-resistant containers at 20–25°C (may be exposed to 15–30°C); protect from moisture.105 c
Parenteral
InjectionLight-resistant containers at 20–25°C (may be exposed to 15–30°C);106 avoid freezing.106 c
Compatibility
For information on systemic interactions resulting from concomitant use, see Interactions.
Parenteral
Solution CompatibilityHID Compatible |
Dextrose–Ringer’s injection combinations |
Dextrose–Ringer’s injection, lactated, combinations |
Dextrose–saline combinations |
Dextrose 2.5, 5, or 10% in water |
Ionosol products |
Ringer’s injection |
Ringer’s injection, lactated |
Sodium chloride 0.45 or 0.9% |
Sodium lactate (1/6) M |
Compatible |
Ascorbic acid injection |
Ethacrynate sodium |
Theophylline |
Incompatible |
Aminophylline |
Amphotericin B |
Ampicillin sodium |
Chloramphenicol sodium succinate |
Chlorothiazide sodium |
Cloxacillin sodium |
Furosemide |
Floxacillin sodium |
Methohexital sodium |
Penicillin G potassium or sodium |
Phenobarbital sodium |
Compatible |
Amsacrine |
Cisatracurium besylate |
Cladribine |
Dexmedetomidine HCl |
Docetaxel |
Doxorubicin HCl liposome injection |
Famotidine |
Fenoldopam mesylate |
Filgrastim |
Fluconazole |
Gemcitabine HCl |
Granisetron HCl |
Heparin sodium |
Hetastarch in lactated electrolyte injection (Hextend) |
Hydrocortisone sodium succinate |
Ondansetron HCl |
Oxaliplatin |
Potassium chloride |
Propofol |
Teniposide |
Thiotepa |
Vinorelbine tartrate |
Incompatible |
Allopurinol sodium |
Amifostine |
Amphotericin B cholesteryl sulfate complex |
Aztreonam |
Bivalirudin |
Etoposide phosphate |
Fludarabine phosphate |
Furosemide |
Linezolid |
Melphalan HCl |
Paclitaxel |
Pemetrexed disodium |
Piperacillin sodium–tazobactam sodium |
Sargramostim |
Tigecycline |
Variable |
Remifentanil HCl |
Compatible |
Atropine sulfate |
Benztropine mesylate |
Butorphanol tartrate |
Diphenhydramine HCl |
Doxapram HCl |
Droperidol |
Fentanyl citrate |
Glycopyrrolate |
Hydromorphone HCl |
Hydroxyzine HCl |
Meperidine HCl |
Metoclopramide HCl |
Midazolam HCl |
Morphine sulfate |
Pentazocine lactate |
Prochlorperazine edisylate |
Promethazine HCl |
Scopolamine HBr |
Incompatible |
Heparin sodium |
Pantoprazole sodium |
Pentobarbital sodium |
Variable |
Dimenhydrinate |
Ranitidine HCl |
Preparations
Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.
Please refer to the ASHP Drug Shortages Resource Center for information on shortages of one or more of these preparations.
* available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) name
Routes | Dosage Forms | Strengths | Brand Names | Manufacturer |
---|---|---|---|---|
Oral | Tablets | 10 mg* | chlorproMAZINE Hydrochloride Tablets | |
25 mg* | chlorproMAZINE Hydrochloride Tablets | |||
50 mg* | chlorproMAZINE Hydrochloride Tablets | |||
100 mg* | chlorproMAZINE Hydrochloride Tablets | |||
200 mg* | chlorproMAZINE Hydrochloride Tablets | |||
Parenteral | Injection | 25 mg/mL* | chlorproMAZINE Hydrochloride Injection | Baxter |