Carbidopa and levodopa enteral

Do not use carbidopa and levodopa if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

You should not use this medicine if you are allergic to carbidopa or levodopa.

Do not use Duopa if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

To make sure Duopa is safe for you, tell your doctor if you have:

• a stomach ulcer or a history of stomach surgery;

• low blood pressure, or a history of fainting spells;

• narcolepsy or a history of falling asleep during the daytime;

• a muscle disorder such as myasthenia gravis;

• nerve problems that cause numbness or tingling in your hands or feet;

• a history of depression, mental illness, or psychosis;

• glaucoma; or

• heart disease, high blood pressure, heart rhythm disorder.

People with Parkinson's disease may have a higher risk of skin cancer (melanoma). Talk to your doctor about this risk and what skin symptoms to watch for.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Duopa can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine.

Duopa is not approved for use by anyone younger than 18 years old.

You may need to use extra medicine to make up a missed dose. Call your doctor for instructions if you stop your infusion or disconnect your pump for longer than 2 hours.

To avoid a missed dose, get your prescription refilled before you run out of medicine completely.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

• severe dizziness or light-headed feeling;

• daytime sleepiness or drowsiness;

• uncontrolled muscle movements, worsening of tremors (uncontrolled shaking);

• intense urges such as increased sexual urges, unusual urges to gamble, or other impulsive behaviors;

• confusion, hallucinations, unusual changes in mood or behavior;

• numbness, tingling, or weakness in your hands or feet;

• depression or suicidal thoughts;

• chest pain, fast or irregular heart rate; or

• severe nervous system reaction--very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out.

You may also have complications from the surgical procedure needed to insert the PEG-J tube into your stomach. Tell your caregives right away if you have any of the following signs or symptoms:

• nausea, vomiting, stomach pain;

• severe ongoing constipation;

• fever;

• bloody or tarry stools;

• severe pain in your upper stomach spreading to your back; or

• pain, swelling, redness, warmth, or oozing around the stoma where the PEG-J tube was inserted.

Common side effects may include:

• complications from your surgical procedure;

• swelling around the the PEG-J tube;

• depressed mood;

• swelling in your hands or feet;

• increased blood pressure (severe headache, blurred vision, pounding in your neck or ears);

• mouth or throat pain;

• cold symptoms such as stuffy nose, sneezing; or

• nausea.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Taking this medicine with other drugs that make you sleepy can worsen this effect. Ask your doctor before taking Duopa with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.

Tell your doctor about all your current medicines and any you start or stop using, especially:

• isoniazid;

• metoclopramide;

• blood pressure medication;

• medicines, vitamins, or mineral supplements that contain iron; or

• medicine to treat a psychiatric disorder (such as Abilify, Geodon, Risperdal, Seroquel, Symbyax, or Zyprexa).

This list is not complete. Other drugs may interact with carbidopa and levodopa, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.