Carbinoxamine

Dosage Forms & Strengths

tablet

• 4mg

oral solution

• 4mg/5mL

oral suspension, extended-release (Karbinal ER)

• 4mg/5mL

Allergies

4-8 mg PO q6-8hr PO; not to exceed 24 mg/day

Karbinal ER: 6-16 mg (7.5-20 mL) PO q12hr

Other Indications & Uses

Seasonal & perennial allergic rhinitis, vasomotor rhinitis, allergic conjunctivitis, urticaria & angioedema, dermatographism, anaphylactic reactions adjunctive to epinephrine, amelioration of the severity of allergic reactions to blood or plasma

Dosage Forms & Strengths

tablet

• 4mg

oral solution

• 4mg/5mL

oral suspension, extended-release (Karbinal ER)

• 4mg/5mL

Allergies

2-6 years: 0.2-0.4 mg/kg/day PO divided q6-8hr or 1-2 mg (2.5 mL) PO q6-8hr  

>6 years: 2-4 mg (5-7.5 mL) PO q6-8hr

Karbinal ER

• 2-3 years: 3-4 mg (3.75-5 mL) PO q12hr
• 4-5 years: 3-8 mg (3.75-10 mL) PO q12hr
• 6-11 years: 6-12 mg (7.5-15 mL) PO q12hr
• ≥12 years: 6-16 mg (7.5-20 mL) PO q12hr

Start at lower end of dosage range (4-8 mg PO q6-8hr) and decrease frequency if needed

Nonanticholinergic antihistamines should be considered first when treating allergic reactions (Beers Criteria)

Avoid use in elderly because of high incidence of anticholinergic effects

Clearance reduced with advanced age, greater risk of confusion, dry mouth, constipation, and other anticholinergic effects and toxicity

May exacerbate existing lower urinary conditions or benign prostatic hyperplasia

Carbinoxamine may be found in some form under the following brand names:

• Andec

• Arbinoxa

• Aridex

• Aridex-D

• Balamine DM

• Biodec DM

• Carbaxef-DM

• Carbaxefed RF

• Carbic-D

• Carbinoxamine PD

• Carbiset

• Carbodec

• Carbodec DM

• Carboxine

• Carboxine 12 DM

• Carboxine-PSE

• Cardec

• Cardec DM

• Cardec DM Drops

• Cardec TR

• Cardec-S

• Chemdec

• Chemdec DM

• Coldec

• Cordron NR

• Cordron-12 D

• Cordron-12 DM

• Cordron-D

• Cordron-DM

• CP Oral

• Cydec

• Cydec-DM

• Cydec-DM Drops

• Dacex-A

• Decahist-DM

• Donatussin MAX

• Dura-Ron

• Dura-Ron DM

• Excof

• HistamaxD

• Histex CT

• Histex HC

• Histex I/E

• Histex PD

• Histex Pd 12

• Hydro-Tussin CBX

• Karbinal

• Maldec

• Maldec-DM

• Max HC

• Mintex PD

• Mintex PSE

• Mooredec

• Nacon

• Norel LA

• Palgic

• Palgic-D

• Pannaz

• Pannaz S

• Pediatex

• Pediatex 12

• Pediatex 12 DM

• Pediatex DM

• Pediatex-D

• Pediox

• Pseudox M

• Rondamine

• Rondamine DM

• Rondec Drops

• Sildec DM

• Tri-Vent HC

• Tricold

• Tussafed

• X-Hist

• X-Hist DM

• XiraHist

• XiraHist DM

Carbinoxamine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Carbinoxamine is used to treat runny or stuffy nose, sneezing, itching, watery eyes, hives, skin rash, itching, and other symptoms of allergies and the common cold.

Carbinoxamine may also be used for purposes not listed in this medication guide.

Do not breast-feed a baby while taking this medicine.

Do not use this medicine if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.

Do not give this medicine to a child younger than 2 years old. Death can occur from the misuse of cough and cold medicines in very young children.

You should not use carbinoxamine if you are allergic to it.

Do not use carbinoxamine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

Do not breast-feed a baby while taking carbinoxamine. This medicine may cause side effects in the nursing baby.

Do not give this medicine to a child younger than 2 years old. Death can occur from the misuse of cough and cold medicines in very young children. Talk with your doctor about other FDA-approved products available for use in young children with cold or allergy symptoms. Always ask a doctor before giving a cough or cold medicine to a child.

You should not use antihistamine medication to make a child sleepy.

To make sure carbinoxamine is safe for you, tell your doctor if you have:

• narrow-angle glaucoma;

• heart disease or high blood pressure;

• a stomach ulcer;

• a blockage in your digestive tract (stomach or intestines);

• a bladder obstruction or other urination problems;

• an enlarged prostate;

• asthma; or

• overactive thyroid.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Usual Adult Dose for Allergic Rhinitis:

Tablet (carbinoxamine maleate 4 mg): 1 tablet orally daily as needed; may increase dosage as needed up to a maximum of 24 mg/day in divided doses every 6 to 8 hours

Tablet, timed-release (carbinoxamine maleate 8 mg): 1 tablet orally every 12 hours

Capsule, extended-release (carbinoxamine maleate 2 mg/8 mg): 1 capsule orally every 12 hours, not to exceed 2 capsules in a 24-hour period

Solution (carbinoxamine maleate 4 mg/5 mL): 5 mL orally daily as needed; may increase dosage as needed up to a maximum of 24 mg/day in divided doses every 6 to 8 hours

Suspension (carbinoxamine maleate-tannate 2 mg-6 mg/5 mL): 5 mL orally every 12 hours

Liquid (carbinoxamine maleate 4 mg/5 mL): 5 mL orally 4 times a day

Liquid (carbinoxamine maleate 1.5 mg/5 mL): 10 mL orally 4 times a day

Extended release suspension (carbinoxamine tannate 3.6 mg/5 mL): 10 to 20 mL orally every 12 hours


Liquid (carbinoxamine maleate 1.75 mg/5 mL): 10 mL orally 4 times a day

Usual Adult Dose for Allergic Urticaria:

Tablet (carbinoxamine maleate 4 mg): 1 tablet orally daily as needed; may increase dosage as needed up to a maximum of 24 mg/day in divided doses every 6 to 8 hours

Capsule, extended-release (carbinoxamine maleate 2 mg/8 mg): 1 capsule orally every 12 hours, not to exceed 2 capsules in a 24-hour period

Solution (carbinoxamine maleate 4 mg/5 mL): 5 mL orally daily as needed; may increase dosage as needed up to a maximum of 24 mg/day in divided doses every 6 to 8 hours

Suspension (carbinoxamine maleate-tannate 2 mg-6 mg/5 mL): 5 mL orally every 12 hours

Usual Adult Dose for Allergic Reaction:

Tablet (carbinoxamine maleate 4 mg): 1 tablet orally daily as needed; may increase dosage as needed up to a maximum of 24 mg/day in divided doses every 6 to 8 hours

Solution (carbinoxamine maleate 4 mg/5 mL): 5 mL orally daily as needed; may increase dosage as needed up to a maximum of 24 mg/day in divided doses every 6 to 8 hours

Usual Adult Dose for Allergic Conjunctivitis:

Tablet (carbinoxamine maleate 4 mg): 1 tablet orally daily as needed; may increase dosage as needed up to a maximum of 24 mg/day in divided doses every 6 to 8 hours

Solution (carbinoxamine maleate 4 mg/5 mL): 5 mL orally daily as needed; may increase dosage as needed up to a maximum of 24 mg/day in divided doses every 6 to 8 hours

Usual Adult Dose for Dermatographism:

Tablet (carbinoxamine maleate 4 mg): 1 tablet orally daily as needed; may increase dosage as needed up to a maximum of 24 mg/day in divided doses every 6 to 8 hours

Solution (carbinoxamine maleate 4 mg/5 mL): 5 mL orally daily as needed; may increase dosage as needed up to a maximum of 24 mg/day in divided doses every 6 to 8 hours

Usual Adult Dose for Vasomotor Rhinitis:

Tablet (carbinoxamine maleate 4 mg): 1 tablet orally daily as needed; may increase dosage as needed up to a maximum of 24 mg/day in divided doses every 6 to 8 hours

Solution (carbinoxamine maleate 4 mg/5 mL): 5 mL orally daily as needed; may increase dosage as needed up to a maximum of 24 mg/day in divided doses every 6 to 8 hours

Usual Pediatric Dose for Allergic Rhinitis:

Liquid (carbinoxamine maleate 1.75 mg/5 mL):
Liquid (carbinoxamine maleate 1.5 mg/5 mL):
=6 years: 10 mL orally 4 times a day

Liquid (carbinoxamine maleate 4 mg/5 mL):
Suspension (carbinoxamine maleate-tannate 2 mg-6 mg/5 mL):
=6 years: 5 mL orally 4 times a day

Solution (carbinoxamine maleate 4 mg/5 mL):
=6 years: 5 mL orally daily as needed; may increase dosage as needed up to a maximum of 24 mg/day in divided doses every 6 to 8 hours

Tablet (carbinoxamine maleate 4 mg):
=6 years: 1 tablet orally daily as needed; may increase dosage as needed up to a maximum of 24 mg/day in divided doses every 6 to 8 hours

Tablet, timed-release (carbinoxamine maleate 8 mg):
6 to 12 years: 1/2 tablet orally every 12 hours
>=12 years: 1 tablet orally every 12 hours

Capsule, extended-release (carbinoxamine maleate 2 mg/8 mg):
>=12 years: 1 capsule orally every 12 hours, not to exceed 2 capsules in a 24-hour period

Extended release suspension (carbinoxamine tannate 3.6 mg/5 mL):
2 years to 6 years: 2.5 to 5 mL orally every 12 hours
6 years to 12 years: 5 to 10 mL orally every 12 hours
12 years to 18 years: 10 to 20 mL orally every 12 hours

Usual Pediatric Dose for Allergic Urticaria:

Suspension (carbinoxamine maleate-tannate 2 mg-6 mg/5 mL):
=6 years: 5 mL orally every 12 hours

Solution (carbinoxamine maleate 4 mg/5 mL):
=6 years: 5 mL orally daily as needed; may increase dosage as needed up to a maximum of 24 mg/day in divided doses every 6 to 8 hours

Tablet (carbinoxamine maleate 4 mg):
=6 years: 1 tablet orally daily as needed; may increase dosage as needed up to a maximum of 24 mg/day in divided doses every 6 to 8 hours

Capsule, extended-release (carbinoxamine maleate 2 mg/8 mg):
>=12 years: 1 capsule orally every 12 hours, not to exceed 2 capsules per day

Usual Pediatric Dose for Allergic Reaction:

Solution (carbinoxamine maleate 4 mg/5 mL):
=6 years: 5 mL orally daily as needed; may increase dosage as needed up to a maximum of 24 mg/day in divided doses every 6 to 8 hours

Tablet (carbinoxamine maleate 4 mg):
=6 years: 1 tablet orally daily as needed; may increase dosage as needed up to a maximum of 24 mg/day in divided doses every 6 to 8 hours

Usual Pediatric Dose for Allergic Conjunctivitis:

Solution (carbinoxamine maleate 4 mg/5 mL):
=6 years: 5 mL orally daily as needed; may increase dosage as needed up to a maximum of 24 mg/day in divided doses every 6 to 8 hours

Tablet (carbinoxamine maleate 4 mg):
=6 years: 1 tablet orally daily as needed; may increase dosage as needed up to a maximum of 24 mg/day in divided doses every 6 to 8 hours

Usual Pediatric Dose for Dermatographism:

Solution (carbinoxamine maleate 4 mg/5 mL):
=6 years: 5 mL orally daily as needed; may increase dosage as needed up to a maximum of 24 mg/day in divided doses every 6 to 8 hours

Tablet (carbinoxamine maleate 4 mg):
=6 years: 1 tablet orally daily as needed; may increase dosage as needed up to a maximum of 24 mg/day in divided doses every 6 to 8 hours

Usual Pediatric Dose for Vasomotor Rhinitis:

Solution (carbinoxamine maleate 4 mg/5 mL):
=6 years: 5 mL orally daily as needed; may increase dosage as needed up to a maximum of 24 mg/day in divided doses every 6 to 8 hours

Tablet (carbinoxamine maleate 4 mg):
=6 years: 1 tablet orally daily as needed; may increase dosage as needed up to a maximum of 24 mg/day in divided doses every 6 to 8 hours

Carbinoxamine is used to treat symptoms of seasonal (short-term) or perennial (long-term) allergies, such as sneezing, runny nose, itching, watery eyes, hives, skin rash, itching, or wheezing. It is also used to treat symptoms of allergic rhinitis, allergic conjunctivitis caused by inhaled allergens and foods, or allergic skin reactions. carbinoxamine is an antihistamine.

Carbinoxamine is used with epinephrine to treat severe allergic reactions (anaphylaxis). It is also used to treat allergic reactions to blood or plasma.

carbinoxamine is available only with your doctor's prescription.

Manifestations

Antihistamine overdosage reactions may vary from central nervous system depression to stimulation. Stimulation is particularly likely in children. Atropine-like signs and symptoms - dry mouth; fixed, dilated pupils; flushing; and gastrointestinal symptoms may also occur.

Especially in infants and children, antihistamine overdosage may cause hallucinations, convulsions, or death.

The oral LD50 of Carbinoxamine maleate in guinea pigs is 411 mg/kg.

Treatment

The treatment of overdosage with Carbinoxamine maleate is essentially symptomatic and supportive. Vital signs (including respiration, pulse, blood pressure, and temperature) and EKG should be monitored. Induction of vomiting is not recommended. Activated charcoal should be given and gastric lavage should be considered after ingestion of a potentially life-threatening amount of drug. In the presence of severe anticholinergic effects, physostigmine may be useful. Vasopressors may be used to treat hypotension.

• Ethanolamine Derivative
• Histamine H1 Antagonist
• Histamine H1 Antagonist, First Generation

Allergies: For the symptomatic treatment of seasonal and perennial allergic rhinitis; vasomotor rhinitis; allergic conjunctivitis caused by inhalant allergens and foods; mild, uncomplicated allergic skin manifestations of urticaria and angioedema; dermatographism; as therapy for anaphylactic reactions adjunctive to epinephrine and other standard measures after the acute manifestations have been controlled; amelioration of the severity of allergic reactions to blood or plasma.

Use caution and initiate at lower end of dosing range. Refer to adult dosing.

Frequency not defined.

Cardiovascular: Chest tightness, extrasystoles, hypotension, palpitations, tachycardia

Central nervous system: Ataxia (most frequent), chills, confusion, dizziness (most frequent), drowsiness (most frequent), euphoria, excitability, fatigue, headache, hysteria, insomnia, irritability, nervousness, neuritis, paresthesia, restlessness, sedation (most frequent), seizure, vertigo

Dermatologic: Diaphoresis, skin photosensitivity, skin rash, urticaria

Endocrine & metabolic: Increased uric acid

Gastrointestinal: Anorexia, constipation, diarrhea, epigastric distress (most frequent), nausea, vomiting, xerostomia

Genitourinary: Difficulty in micturition, early menses, urinary frequency, urinary retention

Hematologic & oncologic: Agranulocytosis, hemolytic anemia, thrombocytopenia

Hypersensitivity: Anaphylactic shock, hypersensitivity reaction

Neuromuscular & skeletal: Tremor

Ophthalmic: Blurred vision, diplopia

Otic: Labyrinthitis, tinnitus

Respiratory: Dry nose, dry throat, nasal congestion, thickening of bronchial secretions (most frequent), wheezing