Carbidopa, entacapone, and levodopa

You should not use this medication if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days.

You should not take this medication if you are allergic to carbidopa (Lodosyn), entacapone (Comtan), or levodopa (Larodopa), or if you have narrow-angle glaucoma, unusual skin lesions, or a history of skin cancer.

Tell your doctor about all of your medical conditions, especially heart disease, high blood pressure, asthma or other breathing problems, liver or kidney disease, a hormonal disease, an ulcer, glaucoma, or mental illness. Also tell your doctor about all the medications you use.

It may take up to several weeks of using carbidopa, entacapone, and levodopa before your symptoms improve. Talk with your doctor if your symptoms do not improve or if the effects of this medication seem to wear off quickly in between doses.

Do not stop using carbidopa, entacapone, and levodopa without first talking to your doctor.

Do not take this medication if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days.

You should not take this medication if you are allergic to carbidopa (Lodosyn), entacapone (Comtan), or levodopa (Larodopa), or if you have:

• narrow-angle glaucoma;

• unusual skin lesions that have not been checked by a doctor; or

• a history of malignant melanoma (skin cancer).

To make sure you can safely take this medication, tell your doctor if you have any of these other conditions:

• heart disease, high blood pressure, coronary artery disease, a heart rhythm disorder, or a prior heart attack;

• asthma, chronic obstructive pulmonary disease (COPD), or other breathing disorder;

• kidney disease, liver disease, or bile duct obstruction;

• an endocrine (hormonal) disease;

• a stomach or intestinal ulcer;

• glaucoma; or

• depression or other mental illness.

You may have increased sexual urges, unusual urges to gamble, or other intense urges while taking this medication. Talk with your doctor if you believe you have any intense or unusual urges while taking this medicine.

Carbidopa, entacapone, and levodopa may cause hallucinations (the sensation of hearing or seeing something that is not there). Call your doctor if you experience hallucinations.

Some people taking Parkinson's disease medications have developed skin cancer (melanoma). However, people with Parkinson's disease may have a higher risk of melanoma. Talk to your doctor about this risk and what skin symptoms to watch for. You may need to have regular skin exams.

FDA pregnancy category C. It is not known whether carbidopa, entacapone, and levodopa will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

Carbidopa, entacapone, and levodopa may pass into breast milk and could harm a nursing baby. You should not breast-feed while you are taking carbidopa, entacapone, and levodopa.

Data not available

The amount of entacapone in each of the tablets of the product combinations is 200 mg.

Each product combination contains a 1:4 ratio of carbidopa to levodopa. The numerical suffix on the product name is representative of the amount of carbidopa in the tablet.