Canagliflozin and Metformin Extended-Release Tablets

• It is used to lower blood sugar in patients with high blood sugar (diabetes).

• If you have an allergy to this medicine or any part of this medicine (canagliflozin and metformin extended-release tablets).
• If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
• If you have any of these health problems: Acidic blood problem or type 1 diabetes.
• If you have kidney disease or are on dialysis.
• If you have liver disease.
• If you have had a recent heart attack or stroke.
• If you are not able to eat or drink like normal, including before certain procedures or surgery.
• If you are pregnant or may be pregnant. Do not take this medicine if you are in the second or third trimester of pregnancy.
• If you are breast-feeding. Do not breast-feed while you take this medicine (canagliflozin and metformin extended-release tablets).

This is not a list of all drugs or health problems that interact with this medicine.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this medicine (canagliflozin and metformin extended-release tablets) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

Use this medicine (canagliflozin and metformin extended-release tablets) as ordered by your doctor. Read all information given to you. Follow all instructions closely.

• Take with breakfast.
• Swallow whole. Do not chew, break, or crush.
• You may see something that looks like the tablet in your stool. This is normal and not a cause for concern. If you have questions, talk with your doctor.
• Drink lots of noncaffeine liquids unless told to drink less liquid by your doctor.
• To gain the most benefit, do not miss doses.
• Keep taking this medicine as you have been told by your doctor or other health care provider, even if you feel well.
• Follow the diet and workout plan that your doctor told you about.

What do I do if I miss a dose?

• Take a missed dose as soon as you think about it.
• If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
• Do not take 2 doses at the same time or extra doses.

• Store in the original container at room temperature.
• Store in a dry place. Do not store in a bathroom.
• If stored outside of the original container, throw away any part not used after 30 days.
• Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
• Check with your pharmacist about how to throw out unused drugs.

• If your symptoms or health problems do not get better or if they become worse, call your doctor.
• Do not share your drugs with others and do not take anyone else's drugs.
• Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
• Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
• This medicine comes with an extra patient fact sheet called a Medication Guide. Read it with care. Read it again each time this medicine (canagliflozin and metformin extended-release tablets) is refilled. If you have any questions about this medicine, please talk with the doctor, pharmacist, or other health care provider.
• If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Review Date: October 4, 2017