Canagliflozin and Metformin Tablets

• It is used to lower blood sugar in patients with high blood sugar (diabetes).

• If you have an allergy to this medicine or any part of this medicine (canagliflozin and metformin tablets).
• If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
• If you have any of these health problems: Acidic blood problem or type 1 diabetes.
• If you have kidney disease or are on dialysis.
• If you have liver disease.
• If you have had a recent heart attack or stroke.
• If you are not able to eat or drink like normal, including before certain procedures or surgery.
• If you are pregnant or may be pregnant. Do not take this medicine if you are in the second or third trimester of pregnancy.
• If you are breast-feeding. Do not breast-feed while you take this medicine (canagliflozin and metformin tablets).

This is not a list of all drugs or health problems that interact with this medicine.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this medicine (canagliflozin and metformin tablets) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

• Avoid driving and doing other tasks or actions that call for you to be alert until you see how this medicine affects you.
• Do not drive if your blood sugar has been low. There is a greater chance of you having a crash.
• To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down. Be careful going up and down stairs.
• Be careful in hot weather or while being active. Drink lots of fluids to stop fluid loss.
• If loose stools (diarrhea) happen or you are throwing up, call your doctor. You will need to drink more fluids to keep from losing too much fluid.
• If you are on a low-salt or salt-free diet, talk with your doctor.
• Have blood work checked as you have been told by the doctor. Talk with the doctor.
• This medicine may affect certain lab tests. Tell all of your health care providers and lab workers that you take this medicine (canagliflozin and metformin tablets).
• Check your blood sugar as you have been told by your doctor.
• Too much acid in the blood or urine (ketoacidosis) and very bad urinary tract infections (UTIs) have happened with this medicine. Ketoacidosis can be deadly. Both of these health problems may need to be treated in a hospital. Talk with the doctor.
• It is common to have stomach problems like upset stomach, throwing up, or loose stools (diarrhea) when you start taking this medicine (canagliflozin and metformin tablets). If you have stomach problems later during care, call your doctor right away. This may be a sign of an acid health problem in the blood (lactic acidosis).
• It may be harder to control your blood sugar during times of stress like when you have a fever, an infection, an injury, or surgery. A change in level of physical activity or exercise and a change in diet may also affect your blood sugar. Talk with your doctor.
• Low blood sugar can happen. The chance of low blood sugar may be raised when this medicine is used with other drugs for high blood sugar (diabetes). Signs may be dizziness, headache, feeling sleepy, feeling weak, shaking, a fast heartbeat, confusion, hunger, or sweating. Call your doctor right away if you have any of these signs. Follow what you have been told to do if you get low blood sugar. This may include taking glucose tablets, liquid glucose, or some fruit juices.
• This medicine may raise the chance of a broken bone. Talk with the doctor.
• Kidney problems have happened with this medicine (canagliflozin and metformin tablets). Sometimes, kidney problems may need to be treated in the hospital. Dialysis may also be needed. Talk with your doctor.
• If you are 65 or older, use this medicine with care. You could have more side effects.
• There is a chance of pregnancy in women of childbearing age who have not been ovulating. If you want to avoid pregnancy, use birth control that you can trust while taking this medicine (canagliflozin and metformin tablets).
• This medicine may cause harm to the unborn baby if you take it while you are pregnant. If you are pregnant or you get pregnant while taking this medicine, call your doctor right away.

Use this medicine (canagliflozin and metformin tablets) as ordered by your doctor. Read all information given to you. Follow all instructions closely.

• Take with meals.
• Drink lots of noncaffeine liquids unless told to drink less liquid by your doctor.
• To gain the most benefit, do not miss doses.
• Keep taking this medicine as you have been told by your doctor or other health care provider, even if you feel well.
• Follow the diet and workout plan that your doctor told you about.

What do I do if I miss a dose?

• Take a missed dose as soon as you think about it.
• If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
• Do not take 2 doses at the same time or extra doses.

• Store in the original container at room temperature.
• Store in a dry place. Do not store in a bathroom.
• If stored outside of the original container, throw away any part not used after 30 days.
• Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
• Check with your pharmacist about how to throw out unused drugs.