Capastat Sulfate

Capreomycin is an antibiotic that fights bacteria in the body.

Capreomycin is used in combination with other medicines to treat Mycobacterium tuberculosis.

Capreomycin is usually given after other tuberculosis medications have been tried without success.

Capreomycin may also be used for purposes not listed in this medication guide.

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Capreomycin can harm your kidneys or damage the nerve that controls your hearing. These effects are increased when you also use certain other medicines. Tell your doctor about all medicines you use, and those you start or stop using during your treatment with capreomycin, especially:

• other antibiotics (oral, injected, or inhaled);

• antivirals;

• chemotherapy;

• medicine for bowel disorders;

• medicine to prevent organ transplant rejection; or

• some pain or arthritis medicines (including aspirin, Tylenol, Advil, and Aleve).

This list is not complete. Other drugs may interact with capreomycin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

In the U.S.

• Capastat Sulfate

Available Dosage Forms:

• Powder for Solution

Therapeutic Class: Antitubercular

Chemical Class: Aminoglycoside

Capreomycin injection is used together with other medicines to treat tuberculosis (TB) in patients who have received other medicines that did not work well. Capreomycin is an aminoglycoside antibiotic that works by killing bacteria or preventing their growth.

This medicine is to be given only by or under the direct supervision of your doctor.

• If you have an allergy to capreomycin or any other part of this medicine.
• If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.

This medicine may interact with other drugs or health problems.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Capastat Sulfate with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

• If you need to store this medicine at home, talk with your doctor, nurse, or pharmacist about how to store it.

Applies to capreomycin: intramuscular powder for injection

Renal

Renal side effects have included dose-related nephrotoxicity, including BUN elevations (greater than 20 mg/dL) (36%), BUN elevations (greater than 30 mg/dL) (10%), depression of PSP excretion, abnormal urine sediment, renal insufficiency, and oliguria. At least one case of toxic nephritis and acute tubular necrosis has been reported.[Ref]

A patient with tuberculosis and portal cirrhosis experienced toxic nephritis and acute tubular necrosis coincident with capreomycin therapy. The patient was treated with capreomycin therapy (1 g) and aminosalicylic acid daily for 1 month. The patient developed renal insufficiency and oliguria and died. The autopsy showed subsiding acute tubular necrosis.[Ref]

Nervous system

Nervous system side effects have included ototoxicity and vestibular toxicity including subclinical auditory loss (11%), clinically apparent hearing loss (3%), vertigo, and tinnitus.[Ref]

Local

Local side effects have included pain, induration, and excessive bleeding at the injection site.[Ref]

Hematologic

Hematologic side effects have included leukocytosis, leukopenia, and eosinophilia. Thrombocytopenia has also been reported rarely.[Ref]

Hepatic

Hepatic side effects have included decreased BSP excretion.[Ref]

Metabolic

Metabolic side effects including hypokalemia, hypocalcemia, hypomagnesemia, and electrolyte disturbances resembling Bartter's syndrome have been reported.[Ref]

Some side effects of Capastat Sulfate may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Capreomycin is removed by hemodialysis. The dose should be administered after a dialysis session.