Caprylidene

• Axona

Induces hyperketonemia to provide an alternative energy substrate to glucose in the brain of patients with Alzheimer disease

Metabolism

Processed by lipases in the gut to medium-chain fatty acids (MCFAs); MCFAs under obligate oxidation in the liver and beta-oxidation in the liver mitochondria to form acetyl-CoA and acetoacetyl-CoA. Acetyl-CoA and acetoacetyl-CoA when in excess are combined to form 3-hydroxy-3-methyl-glutaryl-CoA (HMG-CoA) which forms acetoacetate and beta-hydroxybutyrate (ie, ketone bodies) by HMG-CoA lyase.

There are no dosage adjustments provided in the manufacturer's labeling (has not been studied).

Store at 15°C to 30°C (59°F to 86°F), sealed and protected from light and moisture. Reconstituted product may be refrigerated and stored for up to 24 hours. Refrigerated product should be re-blended and thoroughly mixed prior to consumption.

There are no known significant interactions.

>10%: Gastrointestinal: Diarrhea (10% to 24%), nausea (10% to 20%), abdominal distention (17%), flatulence (15% to 17%)

1% to 10%:

Cardiovascular: Hypertension (5%)

Central nervous system: Dizziness (7%), headache (6%), fatigue (4%), pain (4%)

Gastrointestinal: Abdominal pain (10%), dyspepsia (9%)

Respiratory: Cough (4%), rhinitis (4%)

<1% (Limited to important or life-threatening): GI inflammation (exacerbation), syncope

Periodic triglyceride levels in patients who meet criteria indicative of metabolic syndrome; routine renal function tests in patients with a history of renal dysfunction.

• Discuss specific use of drug and side effects with patient as it relates to treatment. (HCAHPS: During this hospital stay, were you given any medicine that you had not taken before? Before giving you any new medicine, how often did hospital staff tell you what the medicine was for? How often did hospital staff describe possible side effects in a way you could understand?)

• Patient may experience diarrhea, abdominal cramps, nausea, flatulence, or headache. Have patient report immediately to prescriber severe dizziness or passing out (HCAHPS).

• Educate patient about signs of a significant reaction (eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat). Note: This is not a comprehensive list of all side effects. Patient should consult prescriber for additional questions.

Intended Use and Disclaimer: Should not be printed and given to patients. This information is intended to serve as a concise initial reference for healthcare professionals to use when discussing medications with a patient. You must ultimately rely on your own discretion, experience and judgment in diagnosing, treating and advising patients.