Azelastine and Fluticasone

• It is used to ease allergy signs.

• If you have an allergy to azelastine, fluticasone, or any other part of azelastine and fluticasone.
• If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.

This medicine may interact with other drugs or health problems.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this medicine with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

• Azelastine/Fluticasone
• Fluticasone Propionate and Azelastine Hydrochloride

• Dymista
• Ticalast

Azelastine competes with histamine for H1receptor sites on effector cells and inhibits the release of histamine and other mediators involved in the allergic response; when used intranasally, reduces hyper-reactivity of the airways; increases the motility of bronchial epithelial cilia, improving mucociliary transport.

Fluticasone belongs to a group of corticosteroids which utilizes a fluorocarbothioate ester linkage at the 17 carbon position; extremely potent vasoconstrictive and anti-inflammatory activity.

There are no contraindications listed in the US labeling.

Canadian labeling: Hypersensitivity to azelastine, fluticasone, or any component of the formulation; untreated fungal, bacterial, or tuberculosis infections of the respiratory tract.

Seasonal allergic rhinitis: Intranasal: One spray (137 mcg azelastine/50 mcg fluticasone) per nostril twice daily

Adverse events have been observed in animal reproduction studies. Refer to individual monographs.