Aztreonam (Oral Inhalation)

• It is used in some people with cystic fibrosis to make breathing better.

• Tell all of your health care providers that you take aztreonam. This includes your doctors, nurses, pharmacists, and dentists.
• Unsafe allergic effects may rarely happen.
• Do not use longer than you have been told. A second infection may happen.
• Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using this medicine while you are pregnant.
• Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

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• Antibiotic, Miscellaneous

US labeling: There are no dosage adjustments provided in the manufacturer’s labeling.

Canadian labeling: No dosage adjustment is necessary; minimal systemic absorption following inhalation.

Reconstitute with 1 mL of sterile diluent (saline) immediately prior to use. Squeeze diluent into opened glass vial. Replace rubber stopper and gently swirl vial until contents have completely dissolved.

Concerns related to adverse effects:

• Beta-lactam allergy: Rare cross-allergenicity to penicillins, cephalosporins, or carbapenems may occur; use with caution in patients with a history of hypersensitivity to beta-lactams.

• Bronchospasm: May occur following nebulization; administer a bronchodilator prior to treatment.

Dosage form specific issues:

• Appropriate use: Safety and efficacy has not been established in patients with FEV1 <25% or >75% predicted. Compare patient’s baseline FEV1 prior to therapy and the presence of other symptoms when deciding if post-treatment FEV1 changes (eg, decline) are caused by a pulmonary exacerbation. Reserve use for CF patients with known Pseudomonas aeruginosa. Patients colonized with Burkholderia cepacia have not been studied.