Tricitrasol

Tricitrasol® Anticoagulant Sodium Citrate Concentrate, 46.7% Trisodium Citrate, is a sterile, non-pyrogenic solution of Trisodium Citrate (Dihydrate), USP.

Each 30 mL of concentrate contains:

pH adjusted with Citric Acid

pH: 6.3 – 6.6

Single patient use only, on a single occasion.

A sodium citrate solution acts as an anticoagulant by the action of the citrate ion chelating free ionized calcium; thus, the calcium ion is unavailable to the coagulation system1.

Tricitrasol® Anticoagulant Sodium Citrate Concentrate, 46.7% Trisodium Citrate, is an anticoagulant used in granulocytapheresis procedures (granulocyte collection by apheresis). Just prior to performing granulocytapheresis, aseptically add 30 mL of Tricitrasol® to 500 mL of the 6% solution of Hydroxyethyl Starch (HES), e.g. Hespan® 2-8. Agitate the resultant solution for 1 minute to assure a uniform concentration of anticoagulant. The resultant solution of Tricitrasol® and 6% solution of HES contains the following concentration depending upon the volume used:

The Tricitrasol®/HES solution is stable for up to 24 hours at room temperature after mixing.

Refer to the manufacturer's Operator's Manual of the apheresis medical device for the directions to perform the granulocytapheresis procedure.

NOT FOR DIRECT INTRAVENOUS INFUSION.

CONCENTRATED ANTICOAGULANT – DILUTE PRIOR TO USE.

Tricitrasol® Anticoagulant Sodium Citrate Concentrate 46.7% Trisodium Citrate

It is recommended that the product be stored at ambient room temperature, 24°C (75°F); however, the product can be stored between 15°C (59°F) and 30°C (86°F). Protect from freezing and exposure to excessive heat should be minimized.

Rx ONLY

Tricitrasol® is a registered trademark of Citra Labs, LLC, Braintree, MA.

Hespan® is a registered trademark of B. Braun Medical, Inc., Irvine, CA.