Ticarcillin and clavulanate Intravenous

In the U.S.

• Timentin
• Timentin Novaplus

Available Dosage Forms:

• Powder for Solution
• Solution

Therapeutic Class: Antibiotic

Pharmacologic Class: Ticarcillin

A nurse or other trained health professional will give you or your child ticarcillin and clavulanate. ticarcillin and clavulanate is given through a needle placed in one of your veins. The medicine must be injected slowly, so your IV tube will need to stay in place for 30 minutes.

Tell your doctor if you are on a low-salt diet.

Your doctor will check your progress closely while you or your child are receiving ticarcillin and clavulanate. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it.

Call your doctor if your symptoms do not improve or if they get worse.

ticarcillin and clavulanate may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and require immediate medical attention. Call your doctor right away if you have itching, hives, hoarseness, shortness of breath, trouble breathing, trouble swallowing, or any swelling of your hands, face, mouth, or throat after you receive ticarcillin and clavulanate.

Ticarcillin and clavulanate combination may cause diarrhea, and in some cases it can be severe. It may occur 2 months or more after you stop using ticarcillin and clavulanate. Do not take any medicine to treat diarrhea without first checking with your doctor. If you have any questions or if mild diarrhea continues or gets worse, check with your doctor.

Before you have any medical tests, tell the doctor in charge that you are using ticarcillin and clavulanate. The results of some tests may be affected by ticarcillin and clavulanate.

Ticarcillin and clavulanate combination may decrease the effects of some oral contraceptives (birth control pills). To avoid an unwanted pregnancy, it is a good idea to use additional contraceptive measures with your pills (e.g. condoms, a diaphragm, or a contraceptive foam or jelly) while using ticarcillin and clavulanate.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

• Blood in the urine
• frequent urination
• lower abdominal or stomach cramping
• painful urination

• Abdominal or stomach cramps, pain, or tenderness
• black, tarry stools
• bleeding gums
• blistering, peeling, or loosening of the skin
• bloating
• changes in skin color
• chest pain or discomfort
• chills
• clay-colored stools
• convulsions
• cough
• dark urine
• diarrhea
• diarrhea, watery and severe, which may also be bloody
• dizziness
• fast heartbeat
• fever
• general tiredness and weakness
• headache
• increased thirst
• irritability
• itching
• joint or muscle pain
• loss of appetite
• lower back or side pain
• muscle twitching
• nausea or vomiting
• pain, tenderness, or swelling of the foot or leg
• pinpoint red spots on the skin
• rash
• red skin lesions, often with a purple center
• red, irritated eyes
• restlessness
• seizures
• shortness of breath
• sore throat
• sores, ulcers, or white spots on the lips or in the mouth
• swelling or inflammation of the mouth
• swollen glands
• unpleasant breath odor
• unusual bleeding or bruising
• unusual tiredness or weakness
• unusual weight loss
• upper right abdominal or stomach pain
• vomiting of blood
• yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
• change in taste or bad unusual or unpleasant (after) taste
• difficulty with moving
• excess air or gas in the stomach or intestines
• full feeling
• heartburn
• muscle aching, cramping, or stiffness
• passing gas
• swollen joints

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Applies to clavulanate / ticarcillin: intravenous powder for solution, intravenous solution

Along with its needed effects, clavulanate / ticarcillin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking clavulanate / ticarcillin:

• Blood in the urine
• frequent urination
• lower abdominal or stomach cramping
• painful urination

• Abdominal or stomach cramps, pain, or tenderness
• black, tarry stools
• bleeding gums
• blistering, peeling, or loosening of the skin
• bloating
• changes in skin color
• chest pain or discomfort
• chills
• clay-colored stools
• convulsions
• cough
• dark urine
• diarrhea
• diarrhea, watery and severe, which may also be bloody
• dizziness
• fast heartbeat
• fever
• general tiredness and weakness
• headache
• increased thirst
• irritability
• itching
• joint or muscle pain
• loss of appetite
• lower back or side pain
• muscle twitching
• nausea or vomiting
• pain, tenderness, or swelling of the foot or leg
• pinpoint red spots on the skin
• rash
• red skin lesions, often with a purple center
• red, irritated eyes
• restlessness
• seizures
• shortness of breath
• sore throat
• sores, ulcers, or white spots on the lips or in the mouth
• swelling or inflammation of the mouth
• swollen glands
• unpleasant breath odor
• unusual bleeding or bruising
• unusual tiredness or weakness
• unusual weight loss
• upper right abdominal or stomach pain
• vomiting of blood
• yellow eyes or skin

Some side effects of clavulanate / ticarcillin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
• change in taste or bad unusual or unpleasant (after) taste
• difficulty with moving
• excess air or gas in the stomach or intestines
• full feeling
• heartburn
• muscle aching, cramping, or stiffness
• passing gas
• swollen joints