Temozolomide Oral Capsule

Name: Temozolomide Oral Capsule

Highlights for temozolomide

TEMOZOLOMIDE (te moe ZOE loe mide) is a chemotherapy drug. It is used to treat some kinds of brain cancer.

This drug also comes in other forms, including Injectable solution

This drug can cause serious side effects. See which side effects you should report to your doctor right away.

Know how to use your medication, and learn what might happen if you miss a dose.

Talk to your healthcare provider if you have any of these conditions.

Know what to watch for and get tips for reducing your risks while taking this drug.

Temozolomide Side Effects

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • breathing problems
  • low blood counts - this medicine may decrease the number of white blood cells, red blood cells, and platelets. You may be at increased risk for infections and bleeding.
  • signs of infection - fever or chills, cough, sore throat, pain or difficulty passing urine
  • signs of decreased platelets or bleeding - bruising, pinpoint red spots on the skin, black, tarry stools, blood in the urine
  • signs of decreased red blood cells - unusually weak or tired, fainting spells, lightheadedness
  • signs and symptoms of liver injury like dark yellow or brown urine; general ill feeling or flu-like symptoms; light-colored stools; loss of appetite; nausea; right upper belly pain; unusually weak or tired; yellowing of the eyes or skin
  • seizures

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • constipation
  • diarrhea
  • hair loss
  • headache
  • vomiting

Temozolomide May Interact with Other Medications

  • vaccines
  • valproic acid
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.

How to Use temozolomide

Take this medicine by mouth with a full glass of water. Do not chew, crush or open the capsules. You can take this medicine with or without food. However, you should always take it the same way each time. Taking this medicine on an empty stomach may reduce nausea. Taking this medicine at bedtime may also reduce nausea. Follow the directions on the prescription label. Take your medicine at regular intervals. Do not take your medicine more often than directed. Do not stop taking except on your doctor's advice.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • infection (especially a virus infection such as chickenpox, cold sores, or herpes)
  • kidney disease
  • liver disease
  • an unusual or allergic reaction to temozolomide, dacarbazine (DTIC), other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding
What if I miss a dose?

If you miss a dose, talk with your health care professional about when to take your next dose. Do not take double or extra doses. If you vomit after a dose, do not take another until your next planned dose.

What should I watch for while using this medicine?

This drug may make you feel generally unwell. This is not uncommon, as chemotherapy can affect healthy cells as well as cancer cells. Report any side effects. Continue your course of treatment even though you feel ill unless your doctor tells you to stop.

Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Call if you get diarrhea. Do not treat yourself. This drug decreases your body's ability to fight infections. Try to avoid being around people who are sick.

This medicine may increase your risk to bruise or bleed. Call your doctor or health care professional if you notice any unusual bleeding.

You may need blood work done while you are taking this medicine.

Do not open the capsules of this medicine. Breathing in or touching the powder in the capsule may be harmful. If the powder accidentally gets on your skin, wash the area thoroughly. If you have difficulty swallowing, contact your doctor or health care professional.

Talk to your doctor about your risk of cancer. You may be more at risk for certain types of cancers if you take this medicine.

This drug may cause birth defects. Both men and women who are taking this medicine should use effective birth control.

Do not become pregnant while taking this medicine. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. Men should not father a child while taking this medicine. Contact your doctor right away if your partner becomes pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.

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