Toremifene Oral Tablet
Name: Toremifene Oral Tablet
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Highlights for toremifene
Toremifene is an oral drug used to treat breast cancer that has spread to other parts of the body. It’s only used in postmenopausal women (women who have gone through menopause).
Toremifene works by blocking estrogen from attaching to the tumor cell. When the hormone can’t get to the cancer cell, the tumor growth may slow down and the cancerous cells may die.
Common side effects include nausea, hot flashes, sweating, and vaginal discharge.
Drinking grapefruit juice can increase the level of toremifene in your body. This raises your chances of side effects. You shouldn’t drink grapefruit juice while taking this medication.
The recommended dose is 60 mg taken once per day.
IMPORTANT INFORMATION-
FDA warning See Details
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Tumor flare-up See Details
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Endometrial cancer See Details
What is toremifene?
Toremifene is a prescription drug. It’s available as an oral tablet.
Toremifene isn’t available as a generic drug.
This drug may be used as part of a combination therapy. That means you need to take it with other drugs.
Why it's used
Toremifene is used to treat breast cancer that has spread to other parts of your body. It’s only used in postmenopausal women (women who have gone through menopause).
How it works
Toremifene belongs to a class of drugs called estrogen agonist/antagonist. A class of drugs refers to medications that work similarly.
More Details
Toremifene Side Effects
Most Common Side Effects
The most common side effects that occur with toremifene include:
hot flashes
sweating
nausea
vaginal discharge
If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.
Serious Side Effects
If you experience any of these serious side effects, call your doctor right away. If your symptoms are potentially life threatening or if you think you’re experiencing a medical emergency, call 9-1-1.
high calcium levels and tumor flare. Symptoms include:
- muscle pain
- redness at the site of your bone tumors
heart attack or heart failure. Symptoms include:
- chest pain
- shortness of breath
- nausea or vomiting
- weight gain or fluid retention
cataracts or vision changes. Symptoms include:
- blurred vision
- dry eyes
blood clot in your lungs. Symptoms include:
- shortness of breath
- sharp chest pain
- coughing up blood
Toremifene May Interact with Other Medications
Toremifene can interact with other medications, herbs, or vitamins you might be taking. That’s why your doctor should manage all of your medications carefully. If you’re curious about how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.
Note: You can reduce your chances of drug interactions by having all of your prescriptions filled at the same pharmacy. That way, a pharmacist can check for possible drug interactions.
Food interactions
Drinking grapefruit juice can increase the level of toremifene in your body. This can raise your chance of side effects. You shouldn’t drink grapefruit juice while you take this drug.
Alcohol interaction
Your body processes alcohol and this drug in similar ways. That means that if you drink alcohol, this drug might take longer to leave your body. You also could experience worse side effects.
Using alcohol while taking toremifene can also cause a sedative effect, which can be dangerous. It may lead to slowed reflexes, poor judgment, and sleepiness.
Medications that might interact with this drug
AntibioticsWhen taken with toremifene, antibiotics can either raise your risk of the heart problem, QT prolongation, increase the amount or toremifene in your body, or do both.
These drugs include:
- erythromycin
- clarithromycin
- levofloxacin
- ofloxacin
- telithromycin
These drugs can increase the amount of toremifene in your body. This can raise your risk of side effects.
These drugs include:
- ketoconazole
- itraconazole
- voriconazole
When taken with toremifene, these drugs can raise your risk of the heart problem, QT prolongation:
These drugs include:
- thioridazine
- haloperidol
When taken with toremifene, these drugs can raise your risk of the heart problem, QT prolongation.
These drugs include:
- tricyclic antidepressants or serotonin-norepinephrine reuptake inhibitors, such as:
- venlafaxine
- amitriptyline
Other drugs used to treat depression can increase the amount of toremifene in your body. This can raise your risk of side effects.
These drugs include:
- selective serotonin reuptake inhibitor. such as:
- nefazodone
When taken with toremifene, these drugs can raise your risk of the heart problem, QT prolongation:
These drugs include:
- quinidine
- procainamide
- disopyramide
- amiodarone
- sotalol
- ibutilide
- dofetilide
These medications can decrease the amount of toremifene in your body. This means that it won’t work as well to treat your cancer.
These drugs include:
- St. John’s wort
These drugs can increase the amount of toremifene in your body. This can raise your risk of side effects.
These drugs include:
- protease Inhibitors, such as:
- atazanavir
- indinavir
- nelfinavir
- ritonavir
- saquinavir
When taken with toremifene, these drugs can raise your risk of the heart problem, QT prolongation.
These drugs include:
- ondansetron
- granisetron
These medications can decrease the amount of toremifene in your body. This means that it won’t work as well to treat your cancer.
These drugs include:
- phenytoin
- phenobarbital
- carbamazepine
Certain steroids can decrease the amount of toremifene in your body. This means that it won’t work as well to treat your cancer.
These drugs include:
- dexamethasone
These medications can decrease the amount of toremifene in your body. This means that it won’t work as well to treat your cancer.
These drugs include:
- rifampin
- rifabutin
Toremifene increases your risk of dangerously high calcium levels. These medications affect how your body gets rid of calcium. This further increases your risk of high calcium levels.
These drugs include:
- hydrochlorothiazide
- chlorthalidone
- metolazone
- chlorothiazide
People with QT prolongation
Toremifene can increase the time it takes for your heart muscle to recharge itself between heartbeats. This can lead to a deadly heart rhythm called Torsade de pointes. If you have a history of QT prolongation, you shouldn’t take toremifene.
Pregnant women
Toremifene is a category D pregnancy drug. That means two things:
- Research in humans has shown adverse effects to the fetus when the mother takes the drug.
- This drug should only be used during pregnancy in serious cases where it's needed to treat a dangerous condition in the mother.
Talk to your doctor if you’re pregnant or planning to become pregnant. Ask your doctor to tell you about the specific harm that may be done to the fetus. This drug should be only used if the potential risk to the fetus is acceptable given the drug’s potential benefit.
Women who are breast-feeding
It isn’t known if toremifene passes into breast milk. If it does, it may cause side effects in a child who is breast-fed.
This drug has been shown to prevent lactation in women.
Talk to your doctor if you breast-feed your baby. You may need to decide whether to stop breast-feeding or stop taking this medication.
For seniors
Older adults may process drugs more slowly. A normal adult dose may cause levels of the drug to build up higher than normal in your body. If you’re a senior, you may need a lower dose or a different dosing schedule.
For children
This medicine hasn’t been studied in children and shouldn’t be used in people under the age of 18 years.
Allergies
Toremifene can cause a severe allergic reaction. Symptoms include:
- trouble breathing
- swelling of your throat or tongue
- hives
Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal (cause death).
How to Take toremifene (Dosage)
All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:
- your age
- the condition being treated
- how severe your condition is
- other medical conditions you have
- how you react to the first dose
What are you taking this medication for?
Metastatic breast cancerBrand: Fareston
Form: Oral tablet Strengths: 60 mg Adult dosage (ages 18–64 years)60 mg taken one time per day.
Child dosage (ages 0–17 years)This medicine hasn’t been studied in children and shouldn’t be used in people under the age of 18 years.
Senior dosage (ages 65 years and older)Older adults may process this drug more slowly. A normal adult dose may cause levels of the drug to build up higher than normal in your body. Your doctor may lower your dose or give you a different dosing schedule.
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you. Important considerations for taking toremifene