Theophylline Oral Tablet

All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:

• your age
• the condition being treated
• how severe your condition is
• other medical conditions you have
• how you react to the first dose

Forms and strengths

Generic: Theophylline

• Form: extended-release tablet
• Strengths: 100 mg, 200 mg, 300 mg, 400 mg, 450 mg, 600 mg

Dosage for asthma or other lung diseases

Adult dosage (ages 18–59 years)

The usual starting dose is 300–400 mg per day. After 3 days, your dose may be increased to 400–600 mg per day if you don’t have any side effects. After 3 more days, if your dose is tolerated and more medication is needed, your dose may be adjusted based on the level of theophylline in your blood.

Child dosage (ages 16–17 years)

The usual starting dose is 300–400 mg per day. After 3 days, your dose may be increased to 400–600 mg per day if you don’t have any side effects. After 3 more days, if your dose is tolerated and more medication is needed, your dose may be adjusted based on the level of theophylline in your blood.

Child dosage (ages 1–15 years who weigh more than 45 kg)

The starting dose is 300–400 mg per day. After 3 days, your doctor may increase your dose to 400–600 mg per day. After 3 more days, your dose may be adjusted as needed based on the level of theophylline in your blood.

Child dosage (ages 1–15 years who weigh less than 45 kg)

The starting dose is 12–14 mg/kg per day up to 300 mg per day. After 3 days, your doctor may increase your dose to 16 mg/kg daily up to a maximum of 400 mg per day if you don’t have any side effects. After 3 more days, if the dose is tolerated, it may be increased to 20 mg/kg daily up to a maximum of 600 mg per day.

This drug is given in divided doses every 4–6 hours. Your dose will be adjusted based on the amount of theophylline in the blood.

Child dosage (babies born at full-term up to 12 months of age)

Your doctor will calculate your child’s dose based on their age and body weight. The dose will be adjusted based on the amount of theophylline in the blood.

• For infants 0–25 weeks: The total daily dose should be divided into 3 equal doses taken by mouth every 8 hours.
• For infants 26 weeks of age and older: The total daily dose should be divided into 4 equal doses taken by mouth every 6 hours.

Child dosage (babies born prematurely less than 12 months old)

• Babies younger than 24 days: 1 mg/kg of body weight
• Babies 24 days and older: 1.5 mg/kg of body weight

Senior dosage (ages 60 years and older)

• The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, more of a drug stays in your body for a longer time. This increases your risk of side effects.
• Your doctor may start you on a lowered dose or a different medication schedule. This can help keep levels of this drug from building up too much in your body.
• Your maximum dose per day shouldn’t be higher than 400 mg.

Special dosage considerations

If you have risk factors for reduced clearance, such as liver disease: Your maximum dose per day shouldn’t be higher than 400 mg.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.

Theophylline is used for long-term treatment. It comes with risks if you don’t take it as prescribed.

If you stop taking the drug or don’t take it at all

Your symptoms, including trouble breathing, may get worse. This can be fatal (cause death).

If you miss doses or don’t take the drug on schedule

Your medication may not work as well or may stop working completely. For this drug to work well, a certain amount needs to be in your body at all times.

If you take too much

You could have dangerous levels of the drug in your body. You may have the following symptoms:

• severe vomiting
• nausea
• feeling restless or irritated
• seizures
• heart rhythm problems

If you think you’ve taken too much of this drug, call your doctor or local poison control center. If your symptoms are severe, call 911 or go to the nearest emergency room right away.   

What to do if you miss a dose

Take the next dose at the usually scheduled time. Don’t make up the missed dose.

How to tell if the drug is working

You may be able to breathe better.

Keep these considerations in mind if your doctor prescribes theophylline for you.

General

• Take the tablets with food. However, don’t take them with a high-fat meal. Taking your dose too close to a high-fat meal may increase your theophylline levels and cause side effects.
• You can cut the scored tablets only.

Storage

• Store theophylline at room temperature between 59°F and 86°F (15°C and 30°C).
• Keep it away from high temperatures.

Refills

A prescription for this medication is refillable. You should not need a new prescription for this medication to be refilled. Your doctor will write the number of refills authorized on your prescription.

Travel

When traveling with your medication:

• Always carry your medication with you. When flying, never put it into a checked bag. Keep it in your carry-on bag.
• Don’t worry about airport x-ray machines. They can’t hurt your medication.
• You may need to show airport staff the pharmacy label for your medication. Always carry the original prescription-labeled box with you.
• Don’t put this medication in your car’s glove compartment or leave it in the car. Be sure to avoid doing this when the weather is very hot or very cold.

Self-management

Your doctor may have you monitor your lung function using a peak flow meter. They will show you how to do this. They may ask you to record your symptoms.

Clinical monitoring

Your doctor may monitor certain health issues. This can help make sure you stay safe while you take this drug. These issues may include:

• Theophylline blood levels. This will help your doctor decide if you’re taking the right dose. Your doctor will monitor these levels as needed. The results will determine if you need a higher or lower dose.

There are other drugs available to treat your condition. Some may be better suited for you than others. Talk to your doctor about other drug options that may work for you.

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.