Ritonavir Oral Solution

• Tell all of your health care providers that you take this medicine. This includes your doctors, nurses, pharmacists, and dentists.
• This medicine interacts with many other drugs. The chance of ritonavir oral solution's side effects may be raised or how well this medicine works may be lowered. The chance of the other drugs' side effects may also be raised. This may include very bad, life-threatening, or deadly side effects. Check with your doctor and pharmacist to make sure that it is safe for you to take ritonavir oral solution with all of your other drugs (prescription or OTC, natural products, vitamins).
• High blood sugar has happened with this medicine. This includes diabetes that is new or worse. Talk with the doctor.
• Check your blood sugar as you have been told by your doctor.
• This medicine may cause high cholesterol and triglyceride levels. Talk with the doctor.
• Some people with hemophilia have had times of more bleeding when taking drugs like this one. If you have hemophilia, talk with your doctor.
• Have blood work checked as you have been told by the doctor. Talk with the doctor.
• This medicine is not a cure for HIV. Stay under the care of your doctor.
• This medicine does not stop the spread of diseases like HIV or hepatitis that are passed through blood or having sex. Do not have any kind of sex without using a latex or polyurethane condom. Do not share needles or other things like toothbrushes or razors. Talk with your doctor.
• This medicine may help the immune system work. If you have an infection that you did not know you had, it may show up when you take ritonavir oral solution. Tell your doctor right away if you notice any signs of infection like fever, sore throat, weakness, cough, or shortness of breath after you start this medicine.
• If giving to your child, the dose of ritonavir oral solution may need to be changed as your child's weight changes. Have your child's weight checked often. Talk with the doctor before changing your child's dose.
• Birth control pills and other hormone-based birth control may not work as well to prevent pregnancy. Use some other kind of birth control also like a condom when taking this medicine.
• This medicine has alcohol and propylene glycol in it. These may cause very bad and sometimes deadly side effects in newborns or young children. Do not use ritonavir oral solution in premature newborns right after birth or in newborns younger than 14 days old unless the doctor tells you to.
• Use with care in children younger than 6 months old. Talk with the doctor.

• Store solution in the original container at room temperature. Keep the cap tightly closed. Throw away when the date on the bottle has been reached.
• Protect from heat.
• Store in a dry place. Do not store in a bathroom.
• Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
• Check with your pharmacist about how to throw out unused drugs.

• If your symptoms or health problems do not get better or if they become worse, call your doctor.
• Do not share your drugs with others and do not take anyone else's drugs.
• Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
• Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
• Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about this medicine, please talk with your doctor, nurse, pharmacist, or other health care provider.
• If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

This information should not be used to decide whether or not to take ritonavir oral solution or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to ritonavir oral solution. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.

Review Date: October 4, 2017

RITONAVIR (ri TOE na veer) is an antiretroviral medicine. It is used with other medicines to treat HIV. This medicine is not a cure for HIV. It will not stop the spread of HIV to others.

This drug also comes in other forms, including Oral capsule, Oral tablet

This drug can cause serious side effects. See which side effects you should report to your doctor right away.

Know how to use your medication, and learn what might happen if you miss a dose.

Talk to your healthcare provider if you have any of these conditions.

Know what to watch for and get tips for reducing your risks while taking this drug.

Side effects that you should report to your doctor or health care professional as soon as possible:

• allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
• fast, irregular heartbeat
• feeling faint or lightheaded, falls
• nausea, vomiting, abdominal pain
• redness, blistering, peeling or loosening of the skin, including inside the mouth

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

• decreased appetite
• diarrhea
• dizziness
• headache
• increased hunger or thirst
• increased urination
• tingling or numbness in the hands or feet or around the mouth
• unusually weak or tired
• weight gain around waist, back, or thinning of face, arms, legs

Do not take this medicine with any of the following medications:

• alfuzosin
• certain medicines for irregular heart beat like amiodarone, bepridil, dofetilide, dronedarone, encainide, flecainide, propafenone, quinidine
• cisapride
• conivaptan
• disulfiram
• eplerenone
• ergot alkaloids like dihydroergotamine, ergonovine, ergotamine, methylergonovine
• lovastatin
• lurasidone
• metronidazole
• midazolam
• pimozide
• ranolazine
• red yeast rice
• rifapentine
• rivaroxaban
• simvastatin
• St. John's wort
• thioridazine
• triazolam
• voriconazole
• ziprasidone

This medicine may also interact with the following medications:

• atovaquone
• bedaquiline
• bosentan
• birth control pills, patches, rings, or injections
• certain medicines for blood pressure, heart disease, irregular heart beat like digoxin, disopyramide, lidocaine, mexiletine, metoprolol, timolol
• certain medicines for cancer like vinblastine, vincristine, dasatinib, nilotinib
• certain medicines for cholesterol like atorvastatin, rosuvastatin
• certain medicines for depression, anxiety, or psychotic disturbances like amitriptyline, bupropion, desipramine, fluoxetine, nefazodone, nortriptyline, paroxetine, quetiapine, risperidone, trazodone
• certain medicines for erectile dysfunction like avanafil, sildenafil, tadalafil, vardenafil
• certain medicines for fungal infections like fluconazole, itraconazole, ketoconazole, posaconazole
• certain medicines for pain like fentanyl, meperidine, methadone, tramadol
• certain medicines for seizures like carbamazepine, clonazepam, ethosuximide, divalproex, lamotrigine, phenytoin
• certain medicines for sleep like buspirone, clorazepate, diazepam, estazolam, flurazepam, zolpidem
• certain medicines that treat or prevent blood clots like warfarin
• clarithromycin
• colchicine
• cyclosporine
• dronabinol
• methamphetamine
• other antivirals for HIV or AIDS
• other medicines that prolong the QT interval (cause an abnormal heart rhythm)
• quinine
• rifabutin
• rifampin
• salmeterol
• simeprevir
• sirolimus
• steroid medicines like budesonide, dexamethasone, fluticasone, prednisone
• tacrolimus
• theophylline