Quetiapine Fumarate
Name: Quetiapine Fumarate
- Quetiapine Fumarate uses
- Quetiapine Fumarate drug
- Quetiapine Fumarate adverse effects
- Quetiapine Fumarate 300 mg
- Quetiapine Fumarate side effects
- Quetiapine Fumarate weight loss
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Side effects
The following adverse reactions are discussed in more detail in other sections of the labeling:
- Increased mortality in elderly patients with dementia-related psychosis [see WARNINGS AND PRECAUTIONS]
- Suicidal thoughts and behaviors in adolescents and young adults [see WARNINGS AND PRECAUTIONS]
- Cerebrovascular adverse reactions, including stroke in elderly patients with dementia-related psychosis [see WARNINGS AND PRECAUTIONS]
- Neuroleptic Malignant Syndrome (NMS) [see WARNINGS AND PRECAUTIONS]
- Metabolic changes (hyperglycemia, dyslipidemia, weight gain) [see WARNINGS AND PRECAUTIONS]
- Tardive dyskinesia [see WARNINGS AND PRECAUTIONS]
- Hypotension [see WARNINGS AND PRECAUTIONS]
- Increases in blood pressure (children and adolescents) [see WARNINGS AND PRECAUTIONS]
- Leukopenia, neutropenia and agranulocytosis [see WARNINGS AND PRECAUTIONS]
- Cataracts [see WARNINGS AND PRECAUTIONS]
- QT Prolongation [see WARNINGS AND PRECAUTIONS]
- Seizures [see WARNINGS AND PRECAUTIONS]
- Hypothyroidism [see WARNINGS AND PRECAUTIONS]
- Hyperprolactinemia [see WARNINGS AND PRECAUTIONS]
- Potential for cognitive and motor impairment [see WARNINGS AND PRECAUTIONS]
- Body temperature regulation [see WARNINGS AND PRECAUTIONS]
- Dysphagia [see WARNINGS AND PRECAUTIONS]
- Discontinuation Syndrome [see WARNINGS AND PRECAUTIONS]
Clinical Study Experience
Because clinical studies are conducted under widely varying conditions, adverse reaction rates observed in the clinical studies of a drug cannot be directly compared to rates in the clinical studies of another drug and may not reflect the rates observed in practice.
AdultsThe information below is derived from a clinical trial database for SEROQUEL consisting of over 4300 patients. This database includes 698 patients exposed to SEROQUEL for the treatment of bipolar depression, 405 patients exposed to SEROQUEL for the treatment of acute bipolar mania (monotherapy and adjunct therapy), 646 patients exposed to SEROQUEL for the maintenance treatment of bipolar I disorder as adjunct therapy, and approximately 2600 patients and/or normal subjects exposed to 1 or more doses of SEROQUEL for the treatment of schizophrenia. Of these approximately 4300 subjects, approximately 4000 (2300 in schizophrenia, 405 in acute bipolar mania, 698 in bipolar depression, and 646 for the maintenance treatment of bipolar I disorder) were patients who participated in multiple dose effectiveness trials, and their experience corresponded to approximately 2400 patient-years. The conditions and duration of treatment with SEROQUEL varied greatly and included (in overlapping categories) open-label and double-blind phases of studies, inpatients and outpatients, fixed-dose and dose-titration studies, and short-term or longer-term exposure. Adverse reactions were assessed by collecting adverse events, results of physical examinations, vital signs, weights, laboratory analyses, ECGs, and results of ophthalmologic examinations.
The stated frequencies of adverse reactions represent the proportion of individuals who experienced, at least once, a treatment-emergent adverse reaction of the type listed.
Adverse Reactions Associated with Discontinuation of Treatment in Short-Term, Placebo-Controlled TrialsSchizophrenia: Overall, there was little difference in the incidence of discontinuation due to adverse reactions (4% for SEROQUEL vs. 3% for placebo) in a pool of controlled trials. However, discontinuations due to somnolence (0.8% SEROQUEL vs. 0% placebo) and hypotension (0.4% SEROQUEL vs. 0% placebo) were considered to be drug related [see WARNINGS AND PRECAUTIONS].
Bipolar Disorder
Mania: Overall, discontinuations due to adverse reactions were 5.7% for SEROQUEL vs. 5.1% for placebo in monotherapy and 3.6% for SEROQUEL vs. 5.9% for placebo in adjunct therapy. Depression: Overall, discontinuations due to adverse reactions were 12.3% for SEROQUEL 300 mg vs. 19.0% for SEROQUEL 600 mg and 5.2% for placebo.
Commonly Observed Adverse Reactions In Short-Term, Placebo-Controlled Trials
In the acute therapy of schizophrenia (up to 6 weeks) and bipolar mania (up to 12 weeks) trials, the most commonly observed adverse reactions associated with the use of SEROQUEL monotherapy (incidence of 5% or greater) and observed at a rate on SEROQUEL at least twice that of placebo were somnolence (18%), dizziness (11%), dry mouth (9%), constipation (8%), ALT increased (5%), weight gain (5%), and dyspepsia (5%).
Adverse Reactions Occurring at an Incidence of 2% or More Amo ng SEROQUEL Treated Patients in Short-Term, Placebo-Controlled TrialsThe prescriber should be aware that the figures in the tables and tabulations cannot be used to predict the incidence of side effects in the course of usual medical practice where patient characteristics and other factors differ from those that prevailed in the clinical trials. Similarly, the cited frequencies cannot be compared with figures obtained from other clinical investigations involving different treatments, uses, and investigators. The cited figures, however, do provide the prescribing physician with some basis for estimating the relative contribution of drug and nondrug factors to the side effect incidence in the population studied.
Table 9 enumerates the incidence, rounded to the nearest percent, of adverse reactions that occurred during acute therapy of schizophrenia (up to 6 weeks) and bipolar mania (up to 12 weeks) in 2% or more of patients treated with SEROQUEL (doses ranging from 75 to 800 mg/day) where the incidence in patients treated with SEROQUEL was greater than the incidence in placebo-treated patients.
Table 9: Adverse Reaction Incidence in 3- to 12-Week Placebo-Controlled Clinical Trials for the Treatment of Schizophrenia and Bipolar Mania (Monotherapy)
| Preferred Term | SEROQUEL (n=719) | PLACEBO (n=404) |
| Headache | 21% | 14% |
| Agitation | 20% | 17% |
| Somnolence | 18% | 8% |
| Dizziness | 11% | 5% |
| Dry Mouth | 9% | 3% |
| Constipation | 8% | 3% |
| Pain | 7% | 5% |
| Tachycardia | 6% | 4% |
| Vomiting | 6% | 5% |
| Asthenia | 5% | 3% |
| Dyspepsia | 5% | 1% |
| Weight Gain | 5% | 1% |
| ALT Increased | 5% | 1% |
| Anxiety | 4% | 3% |
| Pharyngitis | 4% | 3% |
| Rash | 4% | 2% |
| Abdominal Pain | 4% | 1% |
| Postural Hypotension | 4% | 1% |
| Back Pain | 3% | 1% |
| AST Increased | 3% | 1% |
| Rhinitis | 3% | 1% |
| Fever | 2% | 1% |
| Gastroenteritis | 2% | 0% |
| Amblyopia | 2% | 1% |
In the acute adjunct therapy of bipolar mania (up to 3 weeks) studies, the most commonly observed adverse reactions associated with the use of SEROQUEL (incidence of 5% or greater) and observed at a rate on SEROQUEL at least twice that of placebo were somnolence (34%), dry mouth (19%), asthenia (10%), constipation (10%), abdominal pain (7%), postural hypotension (7%), pharyngitis (6%), and weight gain (6%).
Table 10 enumerates the incidence, rounded to the nearest percent, of adverse reactions that occurred during therapy (up to 3 weeks) of acute mania in 2% or more of patients treated with SEROQUEL (doses ranging from 100 to 800 mg/day) used as adjunct therapy to lithium and divalproex where the incidence in patients treated with SEROQUEL was greater than the incidence in placebo-treated patients.
Table 10: Adverse Reaction Incidence in 3-Week Placebo-Controlled Clinical Trials for the Treatment of Bipolar Mania (Adjunct Therapy)
| Preferred Term | SEROQUEL (n=196) | PLACEBO (n=203) |
| Somnolence | 34% | 9% |
| Dry Mouth | 19% | 3% |
| Headache | 17% | 13% |
| Asthenia | 10% | 4% |
| Constipation | 10% | 5% |
| Dizziness | 9% | 6% |
| Tremor | 8% | 7% |
| Abdominal Pain | 7% | 3% |
| Postural Hypotension | 7% | 2% |
| Agitation | 6% | 4% |
| Weight Gain | 6% | 3% |
| Pharyngitis | 6% | 3% |
| Back Pain | 5% | 3% |
| Hypertonia | 4% | 3% |
| Rhinitis | 4% | 2% |
| Peripheral Edema | 4% | 2% |
| Twitching | 4% | 1% |
| Dyspepsia | 4% | 3% |
| Depression | 3% | 2% |
| Amblyopia | 3% | 2% |
| Speech Disorder | 3% | 1% |
| Hypotension | 3% | 1% |
| Hormone Level Altered | 3% | 0% |
| Heaviness | 2% | 1% |
| Infection | 2% | 1% |
| Fever | 2% | 1% |
| Hypertension | 2% | 1% |
| Tachycardia | 2% | 1% |
| Increased Appetite | 2% | 1% |
| Hypothyroidism | 2% | 1% |
| Incoordination | 2% | 1% |
| Thinking Abnormal | 2% | 0% |
| Anxiety | 2% | 0% |
| Ataxia | 2% | 0% |
| Sinusitis | 2% | 1% |
| Sweating | 2% | 1% |
| Urinary Tract Infection | 2% | 1% |
In bipolar depression studies (up to 8 weeks), the most commonly observed treatment emergent adverse reactions associated with the use of SEROQUEL (incidence of 5% or greater) and observed at a rate on SEROQUEL at least twice that of placebo were somnolence (57%), dry mouth (44%), dizziness (18%), constipation (10%), and lethargy (5%).
Table 11 enumerates the incidence, rounded to the nearest percent, of adverse reactions that occurred during therapy (up to 8 weeks) of bipolar depression in 2% or more of patients treated with SEROQUEL (doses of 300 and 600 mg/day) where the incidence in patients treated with SEROQUEL was greater than the incidence in placebo-treated patients.
Table 11: Adverse Reaction Incidence in 8-Week Placebo-Controlled Clinical Trials for the Treatment of Bipolar Depression
| Preferred Term | SEROQUEL (n=698) | PLACEBO (n=347) |
| Somnolence3 | 57% | 15% |
| Dry Mouth | 44% | 13% |
| Dizziness | 18% | 7% |
| Constipation | 10% | 4% |
| Fatigue | 10% | 8% |
| Dyspepsia | 7% | 4% |
| Vomiting | 5% | 4% |
| Increased Appetite | 5% | 3% |
| Lethargy | 5% | 2% |
| Nasal Congestion | 5% | 3% |
| Orthostatic Hypotension | 4% | 3% |
| Akathisia | 4% | 1% |
| Palpitations | 4% | 1% |
| Vision Blurred | 4% | 2% |
| Weight increased | 4% | 1% |
| Arthralgia | 3% | 2% |
| Paraesthesia | 3% | 2% |
| Cough | 3% | 1% |
| Extrapyramidal Disorder | 3% | 1% |
| Irritability | 3% | 1% |
| Dysarthria | 3% | 0% |
| Hypersomnia | 3% | 0% |
| Sinus Congestion | 2% | 1% |
| Abnormal Dreams | 2% | 1% |
| Tremor | 2% | 1% |
| Gastroesophageal Reflux Disease | 2% | 1% |
| Pain in Extremity | 2% | 1% |
| Asthenia | 2% | 1% |
| Balance Disorder | 2% | 1% |
| Hypoaesthesia | 2% | 1% |
| Dysphagia | 2% | 0% |
| Restless Legs Syndrome | 2% | 0% |
| 3 Somnolence combines adverse reaction terms somnolence and sedation |
Explorations for interactions on the basis of gender, age, and race did not reveal any clinically meaningful differences in the adverse reaction occurrence on the basis of these demographic factors.
Dose Dependency Of Adverse Reactions In Short-Term, Placebo-Controlled TrialsDose-related Adverse Reactions: Spontaneously elicited adverse reaction data from a study of schizophrenia comparing five fixed doses of SEROQUEL (75 mg, 150 mg, 300 mg, 600 mg, and 750 mg/day) to placebo were explored for dose-relatedness of adverse reactions. Logistic regression analyses revealed a positive dose response (p<0.05) for the following adverse reactions: dyspepsia, abdominal pain, and weight gain.
Adverse Reactions in clinical trials with quetiapine and not listed elsewhere in the label:The following adverse reactions have also been reported with quetiapine: nightmares, hypersensitivity and elevations in serum creatine phosphokinase (not associated with NMS), galactorrhea, bradycardia (which may occur at or near initiation of treatment and be associated with hypotension and/ or syncope) decreased platelets, somnambulism (and other related events), elevations in gamma-GT levels, hypothermia, and priapism.
Extrapyramidal Symptoms (EPS)
DystoniaClass Effect: Symptoms of dystonia, prolonged abnormal contractions of muscle groups, may occur in susceptible individuals during the first few days of treatment. Dystonic symptoms include: spasm of the neck muscles, sometimes progressing to tightness of the throat, swallowing difficulty, difficulty breathing, and/or protrusion of the tongue. While these symptoms can occur at low doses, they occur more frequently and with greater severity with high potency and at higher doses of first generation antipsychotic drugs. An elevated risk of acute dystonia is observed in males and younger age groups.
Four methods were used to measure EPS: (1) Simpson-Angus total score (mean change from baseline) which evaluates Parkinsonism and akathisia, (2) Barnes Akathisia Rating Scale (BARS) Global Assessment Score, (3) incidence of spontaneous complaints of EPS (akathisia, akinesia, cogwheel rigidity, extrapyramidal syndrome, hypertonia, hypokinesia, neck rigidity, and tremor), and (4) use of anticholinergic medications to treat emergent EPS.
Adults: Data from one 6-week clinical trial of schizophrenia comparing five fixed doses of SEROQUEL (75, 150, 300, 600, 750 mg/day) provided evidence for the lack of treatment-emergent extrapyramidal symptoms (EPS) and dose-relatedness for EPS associated with SEROQUEL treatment. Three methods were used to measure EPS: (1) Simpson-Angus total score (mean change from baseline) which evaluates Parkinsonism and akathisia, (2) incidence of spontaneous complaints of EPS (akathisia, akinesia, cogwheel rigidity, extrapyramidal syndrome, hypertonia, hypokinesia, neck rigidity, and tremor), and (3) use of anticholinergic medications to treat emergent EPS.
In Table 12, dystonic event included nuchal rigidity, hypertonia, dystonia, muscle rigidity, oculogyration; parkinsonism included cogwheel rigidity, tremor, drooling, hypokinesia; akathisia included akathisia, psychomotor agitation; dyskinetic event included tardive dyskinesia, dyskinesia, choreoathetosis; and other extrapyramidal event included restlessness, extrapyramidal disorder, movement disorder.
Table 12: Adverse Reactions Associated with EPS in a Short-Term, Placebo-Controlled Multiple Fixed-Dose Phase III Schizophrenia Trial (6 weeks duration)
| Preferred Term | SEROQUEL 75 mg/day (N=53) | SEROQUEL 150 mg/day (N=48) | SEROQUEL 300 mg/day (N=52) | SEROQUEL 600 mg/day (N=51) | SEROQUEL 750 mg/day (N=54) | Placebo (N=51) | ||||||
| n | % | n | % | n | % | n | % | n | % | n | % | |
| Dystonic event | 2 | 3.8 | 2 | 4.2 | 0 | 0.0 | 2 | 3.9 | 3 | 5.6 | 4 | 7.8 |
| Parkinsonism | 2 | 3.8 | 0 | 0.0 | 1 | 1.9 | 1 | 2.0 | 1 | 1.9 | 4 | 7.8 |
| Akathisia | 1 | 1.9 | 1 | 2.1 | 0 | 0.0 | 0 | 0.0 | 1 | 1.9 | 4 | 7.8 |
| Dyskinetic event | 2 | 3.8 | 0 | 0.0 | 0 | 0.0 | 1 | 2.0 | 0 | 0.0 | 0 | 0.0 |
| Other extrapyramidal event | 2 | 3.8 | 0 | 0.0 | 3 | 5.8 | 3 | 5.9 | 1 | 1.9 | 4 | 7.8 |
Parkinsonism incidence rates as measured by the Simpson-Angus total score for placebo and the five fixed doses (75, 150, 300, 600, 750 mg/day) were: -0.6; -1.0, -1.2; -1.6; -1.8 and -1.8. The rate of anticholinergic medication use to treat emergent EPS for placebo and the five fixed doses was: 14%; 11%; 10%; 8%; 12% and 11%.
In six additional placebo-controlled clinical trials (3 in acute mania and 3 in schizophrenia) using variable doses of SEROQUEL, there were no differences between the SEROQUEL and placebo treatment groups in the incidence of EPS, as assessed by Simpson-Angus total scores, spontaneous complaints of EPS and the use of concomitant anticholinergic medications to treat EPS.
In two placebo-controlled clinical trials for the treatment of bipolar depression using 300 mg and 600 mg of SEROQUEL, the incidence of adverse reactions potentially related to EPS was 12% in both dose groups and 6% in the placebo group. In these studies, the incidence of the individual adverse reactions (akathisia, extrapyramidal disorder, tremor, dyskinesia, dystonia, restlessness, muscle contractions involuntary, psychomotor hyperactivity and muscle rigidity) were generally low and did not exceed 4% in any treatment group.
The 3 treatment groups were similar in mean change in SAS total score and BARS Global Assessment score at the end of treatment. The use of concomitant anticholinergic medications was infrequent and similar across the three treatment groups.
Children and Adolescents
The information below is derived from a clinical trial database for SEROQUEL consisting of over 1000 pediatric patients. This database includes 677 patients exposed to SEROQUEL for the treatment of schizophrenia and 393 children and adolescents (10-17 years old) exposed to SEROQUEL for the treatment of acute bipolar mania.
Adverse Reactions Associated With Discontinuation Of Treatment In Short-Term, Placebo-Controlled TrialsSchizophrenia: The incidence of discontinuation due to adverse reactions for quetiapine-treated and placebo-treated patients was 8.2% and 2.7%, respectively. The adverse event leading to discontinuation in 1% or more of patients on SEROQUEL and at a greater incidence than placebo was somnolence (2.7% and 0% for placebo).
Bipolar I Mania: The incidence of discontinuation due to adverse reactions for quetiapine-treated and placebo-treated patients was 11.4% and 4.4%, respectively. The adverse reactions leading to discontinuation in 2% or more of patients on SEROQUEL and at a greater incidence than placebo were somnolence (4.1% vs. 1.1%) and fatigue (2.1% vs. 0).
Commonly Observed Adverse Reactions In Short-Term, Placebo-Controlled TrialsIn therapy for schizophrenia (up to 6 weeks), the most commonly observed adverse reactions associated with the use of quetiapine in adolescents (incidence of 5% or greater and quetiapine incidence at least twice that for placebo) were somnolence (34%), dizziness (12%), dry mouth (7%), tachycardia ( 7%).
In bipolar mania therapy (up to 3 weeks) the most commonly observed adverse reactions associated with the use of quetiapine in children and adolescents (incidence of 5% or greater and quetiapine incidence at least twice that for placebo) were somnolence (53%), dizziness (18%), fatigue (11%), increased appetite (9%), nausea (8%), vomiting (8%), tachycardia (7%), dry mouth (7%), and weight increased (6%).
In an acute (8-week) SEROQUEL XR trial in children and adolescents (10-17 years of age) with bipolar depression, in which efficacy was not established, the most commonly observed adverse reactions associated with the use of SEROQUEL XR (incidence of 5% or greater and at least twice that for placebo) were dizziness 7%, diarrhea 5%, fatigue 5% and nausea 5%.
Adverse Reactions Occurring at an Incidence of ≥ 2% Among SEROQUEL Treated Patients in Short-Term, Placebo-Controlled TrialsSchizophrenia (Adolescents, 13 - 17 years old)
The following findings were based on a 6-week placebo-controlled trial in which quetiapine was administered in either doses of 400 or 800 mg/day.
Table 13 enumerates the incidence, rounded to the nearest percent, of treatment-emergent adverse reactions that occurred during therapy (up to 6 weeks) of schizophrenia in 2% or more of patients treated with SEROQUEL (doses of 400 or 800 mg/day) where the incidence in patients treated with SEROQUEL was at least twice the incidence in placebo-treated patients.
Adverse events that were potentially dose-related with higher frequency in the 800 mg group compared to the 400 mg group included dizziness (8% vs. 15%), dry mouth (4% vs. 10%), and tachycardia (6% vs. 11%).
Table 13: Adverse Reaction Incidence in a 6-Week Placebo-Controlled Clinical Trial for the Treatment of Schizophrenia in Adolescent Patients
| Preferred Term | SEROQUEL 400 mg (n=73) | SEROQUEL 800 mg (n=74) | Placebo (n=75) |
| Somnolence1 | 33% | 35% | 11% |
| Dizziness | 8% | 15% | 5% |
| Dry Mouth | 4% | 10% | 1% |
| Tachycardia2 | 6% | 11% | 0% |
| Irritability | 3% | 5% | 0% |
| Arthralgia | 1% | 3% | 0% |
| Asthenia | 1% | 3% | 1% |
| Back Pain | 1% | 3% | 0% |
| Dyspnoea | 0% | 3% | 0% |
| Abdominal Pain | 3% | 1% | 0% |
| Anorexia | 3% | 1% | 0% |
| Tooth Abscess | 3% | 1% | 0% |
| Dyskinesia | 3% | 0% | 0% |
| Epistaxis | 3% | 0% | 1% |
| Muscle Rigidity | 3% | 0% | 0% |
| 1Somnolence combines adverse reaction terms somnolence and sedation. 2Tachycardia combines adverse reaction terms tachycardia and sinus tachycardia. |
Bipolar I Mania (Children and Adolescents 10 to 17 years old)
The following findings were based on a 3-week placebo-controlled trial in which quetiapine was administered in either doses of 400 or 600 mg/day.
Commonly Observed Adverse ReactionsIn bipolar mania therapy (up to 3 weeks) the most commonly observed adverse reactions associated with the use of quetiapine in children and adolescents (incidence of 5% or greater and quetiapine incidence at least twice that for placebo) were somnolence (53%), dizziness (18%), fatigue (11%), increased appetite (9%), nausea (8%), vomiting (8%), tachycardia (7%), dry mouth (7%), and weight increased (6%).
Table 14 enumerates the incidence, rounded to the nearest percent, of treatment-emergent adverse reactions that occurred during therapy (up to 3 weeks) of bipolar mania in 2% or more of patients treated with SEROQUEL (doses of 400 or 600 mg/day) where the incidence in patients treated with SEROQUEL was greater than the incidence in placebo-treated patients.
Adverse events that were potentially dose-related with higher frequency in the 600 mg group compared to the 400 mg group included somnolence (50% vs. 57%), nausea (6% vs. 10%) and tachycardia (6% vs. 9%).
Table 14: Adverse Reactions in a 3-Week Placebo-Controlled Clinical Trial for the Treatment of Bipolar Mania in Children and Adolescent Patients
| Preferred Term | SEROQUEL 400 mg (n=95) | SEROQUEL 600 mg (n=98) | Placebo (n=90) |
| Somnolence1 | 50% | 57% | 14% |
| Dizziness | 19% | 17% | 2% |
| Nausea | 6% | 10% | 4% |
| Fatigue | 14% | 9% | 4% |
| Increased Appetite | 10% | 9% | 1% |
| Tachycardia2 | 6% | 9% | 1% |
| Dry Mouth | 7% | 7% | 0% |
| Vomiting | 8% | 7% | 3% |
| Nasal Congestion | 3% | 6% | 2% |
| Weight Increased | 6% | 6% | 0% |
| Irritability | 3% | 5% | 1% |
| Pyrexia | 1% | 4% | 1% |
| Aggression | 1% | 3% | 0% |
| Musculoskeletal Stiffness | 1% | 3% | 1% |
| Accidental Overdose | 0% | 2% | 0% |
| Acne | 3% | 2% | 0% |
| Arthralgia | 4% | 2% | 1% |
| Lethargy | 2% | 2% | 0% |
| Pallor | 1% | 2% | 0% |
| Stomach Discomfort | 4% | 2% | 1% |
| Syncope | 2% | 2% | 0% |
| Vision Blurred | 3% | 2% | 0% |
| Constipation | 4% | 2% | 0% |
| Ear Pain | 2% | 0% | 0% |
| Paraesthesia | 2% | 0% | 0% |
| Sinus Congestion | 3% | 0% | 0% |
| Thirst | 2% | 0% | 0% |
| 1Somolence combines adverse reactions terms somnolence and sedation. 2Tachycardia combines adverse reaction terms tachycardia and sinus tachycardia. |
In a short-term placebo-controlled monotherapy trial in adolescent patients with schizophrenia (6-week duration), the aggregated incidence of extrapyramidal symptoms was 12.9% (19/147) for SEROQUEL and 5.3% (4/75) for placebo, though the incidence of the individual adverse events (akathisia, tremor, extrapyramidal disorder, hypokinesia, restlessness, psychomotor hyperactivity, muscle rigidity, dyskinesia) did not exceed 4.1% in any treatment group. In a short-term placebo-controlled monotherapy trial in children and adolescent patients with bipolar mania (3-week duration), the aggregated incidence of extrapyramidal symptoms was 3.6% (7/193) or SEROQUEL and 1.1% (1/90) for placebo.
Table 15 presents a listing of patients with adverse reactions potentially associated with extrapyramidal symptoms in the short-term placebo-controlled monotherapy trial in adolescent patients with schizophrenia (6-week duration).
In Tables 15 - 16 dystonic event included nuchal rigidity, hypertonia, and muscle rigidity; parkinsonism included cogwheel rigidity and tremor; akathisia included akathisia only; dyskinetic event included tardive dyskinesia, dyskinesia, and choreoathetosis; and other extrapyramidal event included restlessness and extrapyramidal disorder.
Table 15: Adverse Reactions Associated with Extrapyramidal Symptoms in the Placebo-controlled Trial in Adolescent Patients with Schizophrenia (6-week duration)
| Preferred Term | SEROQUEL 400 mg/day (N=73) | SEROQUEL 800 mg/day (N=74) | All SEROQUEL (N=147) | Placebo (N=75) | ||||
| n | % | n | % | n | % | n | % | |
| Dystonic event | 2 | 2.7 | 0 | 0.0 | 2 | 1.4 | 0 | 0.0 |
| Parkinsonism | 4 | 5.5 | 4 | 5.4 | 8 | 5.4 | 2 | 2.7 |
| Akathisia | 3 | 4.1 | 4 | 5.4 | 7 | 4.8 | 3 | 4.0 |
| Dyskinetic event | 2 | 2.7 | 0 | 0.0 | 2 | 1.4 | 0 | 0.0 |
| Other Extrapyramidal Event | 2 | 2.7 | 2 | 2.7 | 4 | 2.7 | 0 | 0.0 |
Table 16 presents a listing of patients with adverse reactions associated with extrapyramidal symptoms in a short-term placebo-controlled monotherapy trial in children and adolescent patients with bipolar mania (3-week duration).
Table 16: Adverse Reactions Associated with Extrapyramidal Symptoms in a Placebo-Controlled Trial in Children and Adolescent Patients with Bipolar I Mania (3-week duration)
| Preferred Term1 | SEROQUEL 400 mg/day (N=95) | SEROQUEL 600 mg/day (N=98) | All SEROQUEL (N=193) | Placebo (N=90) | ||||
| n | % | n | % | n | % | n | % | |
| Parkinsonism | 2 | 2.1 | 1 | 1.0 | 3 | 1.6 | 1 | 1.1 |
| Akathisia | 1 | 1.0 | 1 | 1.0 | 2 | 1.0 | 0 | 0.0 |
| Other Extrapyramidal Event | 1 | 1.1 | 1 | 1.0 | 2 | 1.0 | 0 | 0.0 |
| 1 There were no adverse experiences with the preferred term of dystonic or dyskinetic events. | ||||||||
Following is a list of COSTART terms that reflect treatment-emergent adverse reactions as defined in the introduction to the ADVERSE REACTIONS section reported by patients treated with SEROQUEL at multiple doses > 75 mg/day during any phase of a trial within the premarketing database of approximately 2200 patients treated for schizophrenia. All reported reactions are included except those already listed in the tables or elsewhere in labeling, those reactions for which a drug cause was remote, and those reaction terms which were so general as to be uninformative. It is important to emphasize that, although the reactions reported occurred during treatment with SEROQUEL, they were not necessarily caused by it.
Reactions are further categorized by body system and listed in order of decreasing frequency according to the following definitions: frequent adverse reactions are those occurring in at least 1/100 patients (only those not already listed in the tabulated results from placebo-controlled trials appear in this listing); infrequent adverse reactions are those occurring in 1/100 to 1/1000 patients; rare reactions are those occurring in fewer than 1/1000 patients.
Nervous System: Infrequent: abnormal dreams, dyskinesia, thinking abnormal, tardive dyskinesia, vertigo, involuntary movements, confusion, amnesia, psychosis, hallucinations, hyperkinesia, libido increased2, urinary retention, incoordination, paranoid reaction, abnormal gait, myoclonus, delusions, manic reaction, apathy, ataxia, depersonalization, stupor, bruxism, catatonic reaction, hemiplegia; Rare: aphasia, buccoglossal syndrome, choreoathetosis, delirium, emotional lability, euphoria, libido decreased2, neuralgia, stuttering, subdural hematoma.
Body as a Whole: Frequent: flu syndrome; Infrequent: neck pain, pelvic pain2 suicide attempt, malaise, photosensitivity reaction, chills, face edema, moniliasis; Rare: abdomen enlarged.
Digestive System: Frequent: anorexia; Infrequent: increased salivation, increased appetite, gamma glutamyl transpeptidase increased, gingivitis, dysphagia, flatulence, gastroenteritis, gastritis, hemorrhoids, stomatitis, thirst, tooth caries, fecal incontinence, gastroesophageal reflux, gum hemorrhage, mouth ulceration, rectal hemorrhage, tongue edema; Rare: glossitis, hematemesis, intestinal obstruction, melena, pancreatitis.
Cardiovascular System: Infrequent: vasodilatation, QT interval prolonged, migraine, bradycardia, cerebral ischemia, irregular pulse, T wave abnormality, bundle branch block, cerebrovascular accident, deep thrombophlebitis, T wave inversion; Rare: angina pectoris, atrial fibrillation, AV block first degree, congestive heart failure, ST elevated, thrombophlebitis, T wave flattening, ST abnormality, increased QRS duration.
Respiratory System: Frequent: cough increased, dyspnea; Infrequent: pneumonia, epistaxis, asthma; Rare: hiccup, hyperventilation.
Metabolic and Nutritional System: Infrequent: weight loss, alkaline phosphatase increased, hyperlipemia, alcohol intolerance, dehydration, hyperglycemia, creatinine increased, hypoglycemia; Rare: glycosuria, gout, hand edema, hypokalemia, water intoxication.
Skin and Appendages System: Infrequent: pruritus, acne, eczema, contact dermatitis, maculopapular rash, seborrhea, skin ulcer; Rare: exfoliative dermatitis, psoriasis, skin discoloration.
Urogenital System: Infrequent: dysmenorrhea2, vaginitis2, urinary incontinence, metrorrhagia2, impotence2, dysuria, vaginal moniliasis2, abnormal ejaculation2, cystitis, urinary frequency, amenorrhea2, female lactation2, leukorrhea2, vaginal hemorrhage2, vulvovaginitis2, orchitis2; Rare: gynecomastia2, nocturia, polyuria, acute kidney failure.
Special Senses: Infrequent: conjunctivitis, abnormal vision, dry eyes, tinnitus, taste perversion, blepharitis, eye pain; Rare: abnormality of accommodation, deafness, glaucoma.
Musculoskeletal System: Infrequent: pathological fracture, myasthenia, twitching, arthralgia, arthritis, leg cramps, bone pain.
Hemic and Lymphatic System: Infrequent: leukocytosis, anemia, ecchymosis, eosinophilia, hypochromic anemia; lymphadenopathy, cyanosis; Rare: hemolysis, thrombocytopenia.
Endocrine System: Infrequent: hypothyroidism, diabetes mellitus; Rare: hyperthyroidism.
Laboratory, ECG and vital sign changes observed in clinical studies
Laboratory ChangesNeutrophil Counts
Adults: In placebo-controlled monotherapy clinical trials involving 3368 patients on quetiapine fumarate and 1515 on placebo, the incidence of at least one occurrence of neutrophil count <1.0 x 109/L among patients with a normal baseline neutrophil count and at least one available follow up laboratory measurement was 0.3% (10/2967) in patients treated with quetiapine fumarate, compared to 0.1% (2/1349) in patients treated with placebo [see WARNINGS AND PRECAUTIONS].
Transaminase Elevations
Adults: Asymptomatic, transient and reversible elevations in serum transaminases (primarily ALT) have been reported. In schizophrenia trials in adults, the proportions of patients with transaminase elevations of > 3 times the upper limits of the normal reference range in a pool of 3- to 6-week placebo-controlled trials were approximately 6% (29/483) for SEROQUEL compared to 1% (3/194) for placebo. In acute bipolar mania trials in adults, the proportions of patients with transaminase elevations of > 3 times the upper limits of the normal reference range in a pool of 3- to 12-week placebo-controlled trials were approximately 1% for both SEROQUEL (3/560) and placebo (3/294). These hepatic enzyme elevations usually occurred within the first 3 weeks of drug treatment and promptly returned to pre-study levels with ongoing treatment with SEROQUEL. In bipolar depression trials, the proportions of patients with transaminase elevations of > 3 times the upper limits of the normal reference range in two 8-week placebo-controlled trials was 1% (5/698) for SEROQUEL and 2% (6/347) for placebo.
Decreased Hemoglobin
Adults: In short-term placebo-controlled trials, decreases in hemoglobin to ≤ 13 g/dL males, ≤ 12 g/dL females on at least one occasion occurred in 8.3% (594/7155) of quetiapine-treated patients compared to 6.2% (219/3536) of patients treated with placebo. In a database of controlled and uncontrolled clinical trials, decreases in hemoglobin to ≤ 13 g/dL males, ≤ 12 g/dL females on at least one occasion occurred in 11% (2277/20729) of quetiapine-treated patients.
Interference with Urine Drug Screens
There have been literature reports suggesting false positive results in urine enzyme immunoassays for methadone and tricyclic antidepressants in patients who have taken quetiapine. Caution should be exercised in the interpretation of positive urine drug screen results for these drugs, and confirmation by alternative analytical technique (e.g., chromatographic methods) should be considered.
ECG Changes
Adults: Between-group comparisons for pooled placebo-controlled trials revealed no statistically significant SEROQUEL/placebo differences in the proportions of patients experiencing potentially important changes in ECG parameters, including QT, QTc, and PR intervals. However, the proportions of patients meeting the criteria for tachycardia were compared in four 3- to 6-week placebo-controlled clinical trials for the treatment of schizophrenia revealing a 1% (4/399) incidence for SEROQUEL compared to 0.6% (1/156) incidence for placebo. In acute (monotherapy) bipolar mania trials the proportions of patients meeting the criteria for tachycardia was 0.5% (1/192) for SEROQUEL compared to 0% (0/178) incidence for placebo. In acute bipolar mania (adjunct) trials the proportions of patients meeting the same criteria was 0.6% (1/166) for SEROQUEL compared to 0% (0/171) incidence for placebo. In bipolar depression trials, no patients had heart rate increases to > 120 beats per minute. SEROQUEL use was associated with a mean increase in heart rate, assessed by ECG, of 7 beats per minute compared to a mean increase of 1 beat per minute among placebo patients. This slight tendency to tachycardia in adults may be related to SEROQUEL's potential for inducing orthostatic changes [see WARNINGS AND PRECAUTIONS].
Children and Adolescents: In the acute (6 week) schizophrenia trial in adolescents, increases in heart rate (> 110 bpm) occurred in 5.2% (3/73) of patients receiving SEROQUEL 400 mg and 8.5% (5/74) of patients receiving SEROQUEL 800 mg compared to 0% (0/75) of patients receiving placebo. Mean increases in heart rate were 3.8 bpm and 11.2 bpm for SEROQUEL 400 mg and 800 mg groups, respectively, compared to a decrease of 3.3 bpm in the placebo group [see WARNINGS AND PRECAUTIONS].
In the acute (3 week) bipolar mania trial in children and adolescents, increases in heart rate (> 110 bpm) occurred in 1.1% (1/89) of patients receiving SEROQUEL 400 mg and 4.7% (4/85) of patients receiving SEROQUEL 600 mg compared to 0% (0/98) of patients receiving placebo. Mean increases in heart rate were 12.8 bpm and 13.4 bpm for SEROQUEL 400 mg and 600 mg groups, respectively, compared to a decrease of 1.7 bpm in the placebo group [see WARNINGS AND PRECAUTIONS].
In an acute (8-week) SEROQUEL XR trial in children and adolescents (10-17 years of age) with bipolar depression, in which efficacy was not established, increases in heart rate (> 110 bpm 10-12 years and 13-17 years) occurred in 0% of patients receiving SEROQUEL XR and 1.2% of patients receiving placebo. Mean increases in heart rate were 3.4 bpm for SEROQUEL XR, compared to 0.3 bpm in the placebo group [see WARNINGS AND PRECAUTIONS].
Post Marketing Experience
The following adverse reactions were identified during post approval of SEROQUEL. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.
Adverse reactions reported since market introduction which were temporally related to quetiapine therapy include anaphylactic reaction, cardiomyopathy, drug reaction with eosinophilia and systemic symptoms (DRESS), hyponatremia, myocarditis, nocturnal enuresis, pancreatitis, retrograde amnesia, rhabdomyolysis, syndrome of inappropriate antidiuretic hormone secretion (SIADH), Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN).
REFERENCES
2 Adjusted for gender.
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