Pyrimethamine-sulfadoxine
Name: Pyrimethamine-sulfadoxine
Dosing & Uses
Dosage Forms & Strengths
tablet
- 25mg/500mg
Malaria Treatment
Discontinued in the United States
2-3 tablet PO once
Malaria Prophylaxis
1 tablet qWeek OR 2 tablets q2Weeks
Administration
Swallow tablet whole with plenty of fluids after a meal
Maintain adequate fluid intake to avert crystalluria or stone formation
Prophylaxis: take 1st dose 1-2 days before arrival to endemic area, continue throughout stay & 4-6 weeks after return
Other Indications & Uses
Chloroquine-resistant P. falciparum malaria treatment & prophylaxis
Off-label: toxoplasmosis
Dosage Forms & Strengths
tablet
- 25mg/500mg
Malaria Treatment
Discontinued in the United States
5-10 kg: 0.5 tablet
11-20 kg: 1 tablet
21-30 kg: 1.5 tablet
31-45 kg: 2 tablet
>45 kg: 3 tablet
Malaria Prophylaxis
5-10 kg: 0.25 tablet
11-20 kg: 0.5 tablet
21-30 kg: 0.75 tablet
31-45 kg: 1 tablet
>45 kg: 1.5 tablet
Administration
Swallow tablet whole with plenty of fluids after a meal
Maintain adequate fluid intake to avert crystalluria or stone formation
Prophylaxis: give 1st dose 1-2 days before arrival to endemic area, continue throughout stay & 4-6 weeks after return
<2 months old: Safety & efficacy not established
>2 months old: All PO single dose
Warnings
Contraindications
Hypersensitivity to sulfonamides, pyrimethamine
Folate deficiency megaloblastic anemia
Prophylactic use during third trimester of pregnancy/nursing mother
Repeated prophylactic use in renal/hepatic failure, blood dyscrasias
<2 mo
Cautions
Asthma, epilepsy, hepatic/renal impairment, G-6-PD deficiency
Risk of Stevens-Johnson syndrome & toxic epidermal necrolysis (TEN)
- discontinue STAT if skin rash appears
Significant levels of resistant strains in many parts of the world
Avoid prolonged sun exposure
Not routinely used for prophylaxis