Prilocaine

Prilocaine is used in the treatment of:

• Pain

Prilocaine is used in the prevention of:

• Toothache

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

This is not a complete list of Prilocainedrug interactions. Ask your doctor or pharmacist for more information.

Take prilocaine exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

The Prilocaine dose your doctor recommends will be based on the following (use any or all that apply):

• the condition being treated
• other medical conditions you have
• other medications you are taking
• how you respond to this medication
• your weight
• your height
• your age
• your gender

Prilocaine is available in the following doses:

• Lidocaine-prilocaine Topical 2.5%-2.5% Topical Cream
• Lidocaine-prilocaine Topical 2.5%-2.5% Topical Film
• Lidocaine-prilocaine Topical 2.5%-2.5% Topical Kit
• Prilocaine 4% Injectable Solution

Prilocaine is available in the following forms:

• Injectable Solution
• Mucous Membrane Topical Solution
• Topical Cream

Use this medicine as ordered by your doctor. Read all information given to you. Follow all instructions closely.

• Your doctor will give prilocaine.
• It is given as a shot into the skin.

What do I do if I miss a dose?

• Call your doctor to find out what to do.

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if you have any side effects that bother you or do not go away.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

• If your symptoms or health problems do not get better or if they become worse, call your doctor.
• Do not share your drugs with others and do not take anyone else's drugs.
• Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
• Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
• Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
• Check with your pharmacist about how to throw out unused drugs.
• Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about prilocaine, please talk with your doctor, nurse, pharmacist, or other health care provider.
• If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about prilocaine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using prilocaine.

Review Date: October 4, 2017

Local anesthetics bind selectively to the intracellular surface of sodium channels to block influx of sodium into the axon. As a result, depolarization necessary for action potential propagation and subsequent nerve function is prevented. The block at the sodium channel is reversible. When drug diffuses away from the axon, sodium channel function is restored and nerve propagation returns.

Distribution

190 to 260 L; crosses blood-brain barrier

Metabolism

Primarily metabolized hepatically and to a lesser extent renally; prilocaine hydrolyzed by amidases to produce ortho-toluidine and N-propylalanine; these compounds may also undergo ring hydroxylation

Excretion

Urine (<5% as unchanged drug)

Dental anesthesia: Infiltration or conduction block: Initial: 40 to 80 mg (1 to 2 mL) as a 4% solution. AAPD guidelines, 2009 maximum recommended dose within a 2-hour period:

<70 kg: 6 mg/kg (400 mg)

≥70 kg: 400 mg or 5 to 6 cartridges

Note: The effective anesthetic dose varies with procedure, intensity of anesthesia needed, duration of anesthesia required and physical condition of the patient. Always use the lowest effective dose along with careful aspiration.

• Discuss specific use of drug and side effects with patient as it relates to treatment. (HCAHPS: During this hospital stay, were you given any medicine that you had not taken before? Before giving you any new medicine, how often did hospital staff tell you what the medicine was for? How often did hospital staff describe possible side effects in a way you could understand?)

• Have patient report immediately to prescriber confusion, burning or numbness feeling, severe dizziness, passing out, bradycardia, sweating a lot, arrhythmia, fatigue, vision changes, tinnitus, depression, severe anxiety, severe nausea, severe vomiting, difficulty breathing, slow breathing, shallow breathing, seizures, tremors, or twitching (HCAHPS).

• Educate patient about signs of a significant reaction (eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat). Note: This is not a comprehensive list of all side effects. Patient should consult prescriber for additional questions.

Intended Use and Disclaimer: Should not be printed and given to patients. This information is intended to serve as a concise initial reference for health care professionals to use when discussing medications with a patient. You must ultimately rely on your own discretion, experience, and judgment in diagnosing, treating, and advising patients.