Prochlorperazine Maleate

Name: Prochlorperazine Maleate

Interactions for Prochlorperazine Maleate

Specific Drugs and Laboratory Tests

Drug or Test

Interaction

Comments

Anticholinergic drugs (e.g., atropine)

Possible potentiation of anticholinergic effectsb

Use with cautionb

Anticoagulants, oral

Potential decreased effect of oral anticoagulants100 f g

Anticonvulsants (e.g., phenytoin)

Prochlorperazine may lower seizure threshold100 f g

Prochlorperazine may interfere with phenytoin metabolism and precipitate phenytoin toxicity100 f g

Dosage adjustments of anticonvulsants may be necessary100 f g

CNS depressants (e.g., alcohol, anesthetics, opiates)

May potentiate CNS depression100 f g

Use with caution to avoid excessive sedation or CNS depressionb

Epinephrine or dopamine

Concomitant use may cause further lowering of BP100 b f g

Do not use epinephrine or dopamine to treat phenothiazine-induced hypotension100 b f g (see Hypotension under Cautions)

Guanethidine and related compounds

Potential for decreased effectiveness of guanethidine and related compounds100 f g

Lithium

Possible acute encephalopathic syndrome, especially with high serum lithium concentrationsb

Observe patients receiving combined therapy for evidence of adverse neurologic effects; discontinue treatment promptly if such signs or symptoms appearb

Propranolol

Increased plasma concentrations of prochlorperazine and propranolol100 f g

Test for phenylketonuria (PKU)

Potential false positive test results100 f g

Thiazide diuretics

Potential for increased orthostatic hypotension100 f g

Prochlorperazine Maleate Pharmacokinetics

Absorption

Bioavailability

Phenothiazines are generally well absorbed from the GI tract and from parenteral sites.b

Onset

Psychotic disorders: Symptomatic relief may be seen during the first 2 days of oral therapy; however, optimum antipsychotic effect usually requires prolonged administration.d

Antiemetic effects: Onset in 30–40 minutes (conventional tablet), 60 minutes (rectal suppository), or 10–20 minutes (IM administration).a

Duration

Antiemetic effects: Duration of 3–4 hours (conventional tablet, rectal suppository, or IM administration).a

Distribution

Extent

Phenothiazines are distributed into most body tissues and fluids, with high concentrations being distributed into the brain, lungs, liver, kidneys, and spleen.b

Phenothiazines cross the placenta.b m Prochlorperazine is distributed into milk.100 f g

Plasma Protein Binding

Phenothiazines are highly bound to plasma proteins.b

Elimination

Metabolism

Extensively metabolized, principally in the liver.b

Elimination Route

Phenothiazines and their metabolites are excreted in urine and feces.b

Stability

Storage

Rectal

Suppositories

20–25°C.g Do not remove from wrapper until ready to use.g

Oral

Tablets

20–25°C.100 Protect from light.100

Parenteral

Injection

20–25°C; do not freeze.f Protect from light.f

Compatibility

For information on systemic interactions resulting from concomitant use, see Interactions.

Parenteral

Solution CompatibilityHID

Compatible

Dextran 6% in dextrose 5%

Dextran 6% in sodium chloride 0.9%

Dextrose–Ringer’s injection combinations

Dextrose–Ringer’s injection, lactated, combinations

Dextrose–saline combinations

Dextrose 2½, 5, or 10% in water

Ionosol products

Ringer’s injection

Ringer’s injection, lactated

Sodium chloride 0.45 or 0.9%

Sodium lactate (1/6) M

Drug Compatibility Admixture CompatibilityHID

Compatible

Amikacin sulfate

Ascorbic acid injection

Calcium gluconate

Dexamethasone sodium phosphate

Dimenhydrinate

Erythromycin lactobionate

Ethacrynate sodium

Lidocaine HCl

Nafcillin sodium

Penicillin G potassium

Sodium bicarbonate

Incompatible

Aminophylline

Chloramphenicol sodium succinate

Floxacillin sodium

Furosemide

Thiopental sodium

Y-Site CompatibilityHID

Compatible

Amsacrine

Calcium gluconate

Cisatracurium besylate

Cisplatin

Cladribine

Cyclophosphamide

Cytarabine

Dexmedetomidine HCl

Docetaxel

Doxorubicin HCl

Doxorubicin HCl liposome injection

Fluconazole

Granisetron HCl

Heparin sodium

Hetastarch in lactated electrolyte injection (Hextend)

Hydrocortisone sodium succinate

Linezolid

Melphalan HCl

Methotrexate sodium

Ondansetron HCl

Oxaliplatin

Paclitaxel

Potassium chloride

Propofol

Remifentanil HCl

Sargramostim

Sufentanil citrate

Teniposide

Thiotepa

Topotecan HCl

Vinorelbine tartrate

Incompatible

Aldesleukin

Allopurinol sodium

Amifostine

Amphotericin B cholesteryl sulfate complex

Aztreonam

Bivalirudin

Cefepime HCl

Etoposide phosphate

Fenoldopam mesylate

Filgrastim

Fludarabine phosphate

Foscarnet sodium

Gallium nitrate

Gemcitabine HCl

Pemetrexed disodium

Piperacillin sodium–tazobactam sodium

Actions

  • Exhibits weak anticholinergic effects, moderate sedative effects, strong extrapyramidal effects, and strong antiemetic effects.a

  • May antagonize dopamine-mediated neurotransmission at the synapses and may block postsynaptic dopamine receptor sites; however, precise mechanism(s) of action have not been determined.b

  • Exerts an antiemetic effect by directly affecting the medullary chemoreceptor trigger zone (CTZ), apparently by blocking dopamine receptors in the CTZ.a g Inhibits apomorphine-induced vomiting.a

  • Also has peripheral and/or central antagonistic activity against α-adrenergic, serotonergic, histaminic H1, and muscarinic receptors.b

Preparations

Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.

Please refer to the ASHP Drug Shortages Resource Center for information on shortages of one or more of these preparations.

* available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) name

Prochlorperazine

Routes

Dosage Forms

Strengths

Brand Names

Manufacturer

Rectal

Suppositories

25 mg*

Compro

Paddock

Prochlorperazine Suppositories

* available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) name

Prochlorperazine Edisylate

Routes

Dosage Forms

Strengths

Brand Names

Manufacturer

Parenteral

Injection

5 mg (of prochlorperazine) per mL*

Prochlorperazine Edisylate Injection

* available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) name

Prochlorperazine Maleate

Routes

Dosage Forms

Strengths

Brand Names

Manufacturer

Oral

Tablets, film-coated*

5 mg (of prochlorperazine)*

Prochlorperazine Maleate Tablets

10 mg (of prochlorperazine)*

Prochlorperazine Maleate Tablets

Uses

Consult your pharmacist.

How to use Prochlorperazine Maleate Powder

Consult your pharmacist.

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