Polymyxin B Sulfate eent

Name: Polymyxin B Sulfate eent

Uses for Polymyxin B Sulfate

Bacterial Ophthalmic Infections

Used in fixed combination with other anti-infectives (e.g., bacitracin, neomycin, gramicidin, trimethoprim) for treatment of superficial infections of the eye caused by susceptible bacteria.b e k l

Used in fixed combination with corticosteroids and other anti-infectives in certain bacterial ocular infections.a d h i j

Not indicated for treatment or prophylaxis of ophthalmic neonatorum.e

Bacterial Otic Infections

Used in fixed combination with corticosteroids (with or without other anti-infectives) for treatment of otitis externa caused by susceptible bacteria.c f g

Polymyxin B Sulfate Pharmacokinetics

Absorption

Bioavailability

Minimal or no absorption from intact or denuded skin or from mucous membranes.e f

Distribution

Extent

Not known whether topical polymyxin B is distributed into human milk.b e (See Bioavailability under Pharmacokinetics.)

Stability

Storage

Ophthalmic

Ointment

Polymyxin B and bacitracin zinc: 20–25°C.k

Polymyxin B and neomycin sulfates and bacitracin zinc: Tightly closed containers at 15–25°C.l

Polymyxin B and neomycin sulfates, bacitracin zinc, and hydrocortisone acetate: 15–25°C.d

Polymyxin B and neomycin sulfates and dexamethasone: 2–25°C.i

Solution

Polymyxin B and neomycin sulfates and gramicidin: Tightly closed containers at 15–25°C; protect from light.b

Polymyxin B sulfate and trimethoprim sulfate: 20–25°C; protect from light.e

Suspension

Polymyxin B sulfate and neomycin sulfates and dexamethasone: 8–27°C.j

Polymyxin B and neomycin sulfates and hydrocortisone: 20–25°C.a

Polymyxin B and neomycin sulfates and prednisolone acetate: Tightly closed containers at 15–25°C.h Store in upright position; protect from freezing.h

Otic

Solution or Suspension

15–25°C.c g

Preparations

Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.

Please refer to the ASHP Drug Shortages Resource Center for information on shortages of one or more of these preparations.

Bacitracin Zinc and Polymyxin B Sulfate

Routes

Dosage Forms

Strengths

Brand Names

Manufacturer

Ophthalmic

Ointment

Bacitracin Zinc 500 units (of bacitracin) per g and Polymyxin B Sulfate 10,000 units (of polymyxin B) per g

AK-Poly-Bac

Akorn

Bacitracin Zinc and Polymyxin B Sulfate Ophthalmic Ointment

Bausch & Lomb, Fougera
Neomycin and Polymyxin B Sulfate and Bacitracin Zinc

Routes

Dosage Forms

Strengths

Brand Names

Manufacturer

Ophthalmic

Ointment

Neomycin Sulfate 0.35% (of neomycin), Polymyxin B Sulfate 10,000 units (of polymyxin B) per g, and Bacitracin Zinc 400 units (of bacitracin) per g

Neomycin and Polymyxin B Sulfates and Bacitracin Zinc Ophthalmic Ointment

Akorn, Fougera

Neosporin Ophthalmic Ointment

Monarch

* available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) name

Neomycin and Polymyxin B Sulfates, Bacitracin Zinc, and Hydrocortisone

Routes

Dosage Forms

Strengths

Brand Names

Manufacturer

Ophthalmic

Ointment

Neomycin Sulfate 0.35% (of neomycin), Polymyxin B Sulfate 10,000 units (of polymyxin B) per g, Bacitracin Zinc 400 units (of bacitracin) per g, and Hydrocortisone 1%*

Neomycin and Polymyxin B Sulfates, Bacitracin Zinc, and Hydrocortisone Ophthalmic Ointment

Bausch & Lomb, Fougera
Neomycin and Polymyxin B Sulfates, Bacitracin Zinc, and Hydrocortisone Acetate

Routes

Dosage Forms

Strengths

Brand Names

Manufacturer

Ophthalmic

Ointment

Neomycin Sulfate 0.35% (of neomycin), Polymyxin B Sulfate 10,000 units (of polymyxin B) per g, Bacitracin Zinc 400 units (of bacitracin) per g, and Hydrocortisone Acetate 1%

Neomycin and Polymyxin B Sulfates, Bacitracin Zinc, and Hydrocortisone Acetate Ophthalmic Ointment

Fougera

* available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) name

Neomycin and Polymyxin B Sulfates and Dexamethasone

Routes

Dosage Forms

Strengths

Brand Names

Manufacturer

Ophthalmic

Ointment

Neomycin Sulfate 0.35% (of neomycin), Polymyxin B Sulfate 10,000 units (of polymyxin B) per g, and Dexamethasone 0.1%*

Maxitrol (with parabens)

Alcon

Neomycin and Polymyxin B Sulfates and Dexamethasone Ophthalmic Ointment

Bausch & Lomb, Falcon, Fougera

Suspension

Neomycin Sulfate 0.35% (of neomycin), Polymyxin B Sulfate 10,000 units (of polymyxin B) per mL, and Dexamethasone 0.1%*

Maxitrol (with benzalkonium chloride; viscous)

Alcon

Neomycin and Polymyxin B Sulfates and Dexamethasone Ophthalmic Suspension

Bausch & Lomb, Falcon

* available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) name

Neomycin and Polymyxin B Sulfates and Gramicidin

Routes

Dosage Forms

Strengths

Brand Names

Manufacturer

Ophthalmic

Solution

Neomycin Sulfate 0.35% (of neomycin), Polymyxin B Sulfate 10,000 units (of polymyxin B) per mL, and Gramicidin 0.0025%*

Neomycin and Polymyxin B Sulfates and Gramicidin Ophthalmic Solution

Bausch & Lomb

Neosporin Ophthalmic Solution (with alcohol 0.5%, propylene glycol, and thimerosal)

Monarch

* available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) name

Neomycin and Polymyxin B Sulfates and Hydrocortisone

Routes

Dosage Forms

Strengths

Brand Names

Manufacturer

Ophthalmic

Suspension

Neomycin Sulfate 0.35% (of neomycin), Polymyxin B Sulfate 10,000 units (of polymyxin B) per mL, and Hydrocortisone 1%

Neomycin and Polymyxin B Sulfates and Hydrocortisone Ophthalmic Suspension (with propylene glycol and thimerosal)

Falcon

Otic

Solution

Neomycin Sulfate 0.35% (of neomycin), Polymyxin B Sulfate 10,000 units (of polymyxin B) per mL, and Hydrocortisone 1%*

Cortisporin (with potassium metabisulfite and propylene glycol)

Monarch

Neomycin and Polymyxin B Sulfates and Hydrocortisone Otic Solution

Falcon

Suspension

Neomycin Sulfate 0.35% (of neomycin), Polymyxin B Sulfate 10,000 units (of polymyxin B) per mL, and Hydrocortisone 1%*

Neosporin and Polymyxin B Sulfates and Hydrocortisone Otic Suspension (with propylene glycol and thimerosal)

Falcon

Pediotic Suspension (with propylene glycol and thimerosal)

Monarch
Neomycin and Polymyxin B Sulfates and Prednisolone Acetate

Routes

Dosage Forms

Strengths

Brand Names

Manufacturer

Ophthalmic

Suspension

Neomycin Sulfate 0.35% (of neomycin), Polymyxin B Sulfate 10,000 units (of polymyxin B) per mL, and Prednisolone Acetate 0.5%

Poly-Pred (with propylene glycol and thimerosal; viscous)

Allergan
Polymyxin B Sulfate and Trimethoprim Sulfate

Routes

Dosage Forms

Strengths

Brand Names

Manufacturer

Ophthalmic

Solution

Polymyxin B Sulfate 10,000 units (of polymyxin B) per mL and Trimethoprim Sulfate 0.1% (of trimethoprim)

Polymyxin B Sulfate and Trimethoprim Sulfate Ophthalmic Solution (with benzalkonium chloride)

Akorn

Polymyxin B Sulfate and Trimethoprim Sulfate Ophthalmic Solution

Bausch & Lomb

Polytrim (with benzalkonium chloride)

Allergan
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