Polyethylene glycol/electrolytes/sodium ascorbate/ascorbic acid

Dosage Forms & Strengths

polyethylene glycol/electrolytes/sodium ascorbate/ascorbic acid

oral powder for solution

• After reconstitution (of 4 packets/2L) contains Pouch A (100g PEG 3350, 7.5 g sodium sulfate, 2.69g sodium chloride, 1.015 g potassium chloride), and Pouch B (4.7 g ascorbic acid, and 5.9 g sodium ascorbate)

Four separate pouches in kit (2 of pouch A and 2 of pouch B)

1 pouch A and 1 pouch B are dissolved together in water to a volume of 1 L for oral use

Gastrointestinal Lavage

Cleansing of the colon as preparation for colonoscopy in 18 yrs and older: 2 L PO prior to colonoscopy

Split-dose regimen

• Evening before colonoscopy: 1 L PO over 1 hr (240 mL q 15 min)
• Follow with 0.5 L (480mL) clear fluid
• Morning of colonoscopy: At least 3.5 hr before colonoscopy, drink 1 L PO over 1 hr (240 mL q 15 min)
• Follow with 0.5 L (480mL) clear fluid at least 1 hr prior to colonoscopy

Full-dose regimen

• 6 PM the evening before colonoscopy: 1 L PO over 1 hr (240 mL q 15 min)
• Approximately 1.5 hrs later, 1 L PO over 1 hr (240 mL q 15 min)
• Follow with 1 L additional clear liquid during the evening before colonoscopy

Renal Impairment

Pharmacokinetics have not been studied in patients with renal or hepatic insufficiency

Administration

PEG/electrolyte Solution Preparation

• Prepare solution by emptying contents of 1 pouch A and 1 pouch B into a suitable glass container (or the container provided) and adding to the container 1 L lukewarm water
• Mix the solution to ensure that the ingredients are completely dissolved
• Solution can be refrigerated prior to drinking
• Reconstituted solution should be used within 24 hours
• After consumption of the first liter of solution, the above mixing procedure should be repeated with the second pouch A and pouch B to reconstitute the second liter
• No additional ingredients (eg, flavorings) should be added to the solution

Safety and efficacy not established in pediatrics

Contraindications

Hypersensitivity

GI obstruction

Bowel perforation

Gastric retention

Ileus

Toxic colitis

Toxic megacolon

Cautions

Use with caution in patients using concomitant medications that increase the risk of electrolyte abnormalities

Use with caution in patients with severe ulcerative colitis, ileus, gastrointestinal obstruction

Patients with impaired gag reflex and patients prone to regurgitation or aspiration should be observed during the administration

Since product contains sodium ascorbate and ascorbic acid, use with caution in patients with glucose-6-phosphate dehydrogenase (G-6-PD) deficiency

If severe vomiting occurs, check serum electrolytes

Phenylketonurics: product contains phenylalanine

Serious arrythmias reported