Podocon-25

Antimitotic; caustic agent.100 117 118

Specific Drugs

Absorption

Bioavailability

Absorbed systemically following topical application.100 (See Systemic Effects under Cautions.)

Storage

Topical

Tight, light-resistant container at 15–30°C.100 Darkens when exposed to light or temperatures >25°C.118

Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.

Please refer to the ASHP Drug Shortages Resource Center for information on shortages of one or more of these preparations.

* available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) name

Podophyllin is a cytotoxic agent that has been used topically in the treatment of genital warts. It arrests mitosis in metaphase, an effect it shares with other cytotoxic agents such as the vinca alkaloids(2). The active agent is podophyllotoxin, whose concentration varies with the type of podophyllin used; the American source normally containing one-fourth the amount of podophyllotoxin as the Indian source(3).

NOTE: Podocon-25® IS TO BE APPLIED ONLY BY A PHYSICIAN. IT IS NOT TO BE DISPENSED TO THE PATIENT.

Podocon-25® is contraindicated in diabetics, patients using steroids or with poor blood circulation. Podocon-25® should not be used on bleeding warts, moles, birthmarks or unusual warts with hair growing from them. It is recommended that Podocon- 25® not be used during pregnancy (see Pregnancy warning below).

Podophyllin is a powerful caustic and severe irritant. Keep away from the eyes; if eye contact occurs, flush with copious amounts of warm water and consult physician or poison control center immediately for advice.

Rx Only

NDC 0574-0601-15

Podocon-25®

(25% Podophyllin in benzoin tincture)

Topical solution for removal of venereal warts (condylomata acuminata)

NOTE: Podocon-25® is to be applied only by a physician. It is not to be dispensed to the patient.

15 mL

(1/2 FL OZ)