Potassium Iodide

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:

• AMILORIDE/POTASSIUM IODIDE
• AZILSARTAN/POTASSIUM IODIDE
• BENAZEPRIL/POTASSIUM IODIDE
• CANDESARTAN/POTASSIUM IODIDE
• CAPTOPRIL/POTASSIUM IODIDE
• ENALAPRIL/POTASSIUM IODIDE
• EPLERENONE/POTASSIUM IODIDE
• EPROSARTAN/POTASSIUM IODIDE
• FOSINOPRIL/POTASSIUM IODIDE
• IRBESARTAN/POTASSIUM IODIDE
• LISINOPRIL/POTASSIUM IODIDE
• LOSARTAN/POTASSIUM IODIDE
• MOEXIPRIL HYDROCHLORIDE/POTASSIUM IODIDE
• OLMESARTAN/POTASSIUM IODIDE
• PERINDOPRIL/POTASSIUM IODIDE
• POTASSIUM IODIDE/QUINAPRIL
• POTASSIUM IODIDE/RAMIPRIL
• POTASSIUM IODIDE/SPIRONOLACTONE
• POTASSIUM IODIDE/TELMISARTAN
• POTASSIUM IODIDE/TRANDOLAPRIL
• POTASSIUM IODIDE/TRIAMTERENE
• POTASSIUM IODIDE/VALSARTAN

This is not a complete list of Potassium Iodidedrug interactions. Ask your doctor or pharmacist for more information.

Tell your doctor if you are pregnant or plan to become pregnant.

The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

Potassium Iodide falls into category D:

It has been shown that use of Potassium Iodide in pregnant women caused some babies to be born with problems. However, in some serious situations, the benefit of using this medication may be greater than the risk of harm to the baby.

Take potassium iodide exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

The Potassium Iodide dose your doctor recommends will be based on the following (use any or all that apply):

• the condition being treated
• other medical conditions you have
• other medications you are taking
• how you respond to this medication
• your weight
• your height
• your age
• your gender

Potassium Iodide is available in the following doses:

• Aminophylline/ephedrine/pb/k Iodide 130 Mg-16 Mg-8 Mg-195 Mg Oral Tablet
• Chlorpheniramine/codeine/pe/k Iodide 0.75 Mg-5 Mg-2.5 Mg-75 Mg/5 Ml Oral Syrup
• Ephedrine-potassium Iodide 8 Mg-150 Mg/5 Ml Oral Liquid
• Ephedrine/pb/k Iodide/theophylline 24 Mg-24 Mg-320 Mg-130 Mg Oral Tablet
• Iodine Topical 5%-10% Topical Solution
• Iodine-potassium Iodide 5%-10% Oral And Topical Solution
• Potassium Iodide 1 G/ml Oral Solution
• Potassium Iodide 130 Mg Oral Tablet
• Potassium Iodide 325 Mg/5 Ml Oral Liquid
• Potassium Iodide 65 Mg Oral Tablet
• Potassium Iodide Compounding Powder
• Potassium Iodide-theophylline 130 Mg-80 Mg/15 Ml Oral Elixir
• Sodium Iodide 5%-10% Oral Liquid

You should not use this medication if you have a history of previous allergic reaction to iodide, iodine, or other medicines.

To make sure potassium iodide is safe for you, tell your doctor if you have:

• kidney disease;

• high levels of potassium (hyperkalemia) in your blood;

• Addison's disease (an adrenal gland disorder);

• tuberculosis;

• a thyroid disorder;

• heart disease; or

• a genetic muscle disorder.

FDA pregnancy category D. Do not use potassium iodide if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment.

Potassium iodide can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine.

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Oral

20–25°C; keep in original foil pack and protect from moisture.150 153 164

65-mg/mL solution: Tight container at 25°C (may be exposed to 15–30°C); protect from light.155

1-g/mL solution (also known as saturated solution of potassium iodide [SSKI]): Tight container at 15–30°C; protect from light.137 Crystallization may occur if exposed to cold temperatures; crystals will dissolve if solution is warmed and shaken.137 Discard if solution turns brownish-yellow.137

Extemporaneous oral solution (liquid mixture) prepared using 65- or 130-mg tablets (see Extemporaneous Oral Solutions under Dosage and Administration): Store in refrigerator; discard any unused solution after 7 days.140 150 153 164

Graves hyperthyroidism (following radioactive iodine therapy)

Data from a retrospective study suggest that potassium iodide may be beneficial in select patients with Graves hyperthyroidism (eg, those who would be candidates for but are allergic to antithyroid drugs) in order to shorten the duration of hyperthyroidism after receiving radioactive iodine therapy [Ross 1983]. Additional data may be necessary to further define the role of potassium iodide in this condition.

Sporotrichosis (cutaneous, lymphocutaneous)

Based on the Infectious Diseases Society of America (IDSA) Clinical Practice Guidelines for the Management of Sporotrichosis: 2007 update, potassium iodide is recommended as alternative therapy for nonpregnant adults and children with cutaneous or lymphocutaneous sporotrichosis who do not respond to or otherwise cannot receive itraconazole.

Thyroidectomy preparation

Based on the American Thyroid Association and American Association of Clinical Endocrinologists guidelines for the management of hyperthyroidism and other causes of thyrotoxicosis, potassium iodide is recommended in the immediate preoperative period in patients with Graves disease undergoing thyroidectomy to reduce thyroid blood flow, vascularity, and intraoperative blood loss. Potassium iodide is not recommended in the preoperative setting in patients with thyrotoxicosis caused by a toxic adenoma or toxic multinodular goiter due to the risk of exacerbating hyperthyroidism [Ross 2016].

Thyroid gland protection during radiopharmaceutical use

Based on the European Association of Nuclear Medicine (EANM) procedure guidelines for 131I-meta-iodobenzylguanidine (131I-mIBG) therapy and the guidelines for radioiodinated MIBG scintigraphy in children, potassium iodide is effective and recommended when given as thyroid gland protection during radiopharmaceutical use.

Thyrotoxic crisis/thyroid storm

Clinical experience suggests the utility of potassium iodide in managing children with thyrotoxic crisis/thyroid storm [Eyal 2008]. Additional data may be necessary to further define the role of potassium iodide for the treatment of this condition.

Based on the American Thyroid Association and American Association of Clinical Endocrinologists guidelines for the diagnosis and management of hyperthyroidism and other causes of thyrotoxicosis, potassium iodide given to adults for thyrotoxic crisis/thyroid storm is effective and recommended in the management of this condition.

There are no dosage adjustments provided in the manufacturer's labeling; use with caution.

Oral:

SSKI: Dilute in a glassful of water, fruit juice, or milk. Administer with food or milk to decrease gastric irritation.

iOSAT, Thyrosafe, Thyroshield: Administer as soon as possible after instructed to do so by public officials. Do not take more than 1 dose in 24 hours. Tablets may be administered whole or crushed and then mixed with water, low fat milk (white or chocolate), orange juice, soda (flat), raspberry syrup, or infant formula. Raspberry syrup disguises the taste best; low-fat white milk or water do not hide the salty taste well) (AAP 2003). See Extemporaneously Prepared.