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Alirocumab is a human monoclonal antibody. It works by helping the liver reduce levels of "bad" cholesterol (low-density lipoprotein, or LDL) circulating in your blood.

Alirocumab is used together with a low-fat diet and a "statin" medication in people with heterozygous familial hypercholesterolemia (an inherited type of high cholesterol). This condition can cause high blood levels of LDL cholesterol, and can also cause plaque to build up inside your arteries.

Alirocumab is also used to treat heart disease with plaque build-up in the arteries (atherosclerosis, sometimes called hardening of the arteries).

Alirocumab may also be used for purposes not listed in this medication guide.

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Do not inject alirocumab into skin that is sunburned, infected, swollen, or otherwise irritated.

Get emergency medical help if you have signs of an allergic reaction: hives, severe itching; difficult breathing; swelling of your face, lips, tongue, or throat.

Common side effects may include:

• redness, itching, soreness, or swelling where an injection was given;

• flu symptoms; or

• cold symptoms such as stuffy nose, sneezing, sore throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Other drugs may interact with alirocumab, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.