Panitumumab Intravenous

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

• Anxiety
• bloating or swelling of the face, arms, hands, lower legs, ankles, or feet
• chest pain
• chills
• confusion
• constipation
• convulsions
• cough
• decreased urination
• deep cracks, grooves, or lines in the skin
• diarrhea
• difficulty with swallowing
• discoloration of the fingernails or toenails
• drowsiness
• dry mouth, lips, or skin
• fainting
• fast or irregular heartbeat
• fever
• flushing or redness of the skin
• increased thirst
• itching, pain, and swelling of the eyelid
• itching, skin rash
• loosening of the fingernails
• loss of appetite
• muscle pain or cramps
• muscle spasms or twitching
• nausea
• rapid weight gain
• rapid, shallow breathing
• redness or soreness around the fingernails
• sores, ulcers, or white spots on the lips, tongue, or inside the mouth
• stomach pain
• sunken eyes
• swelling or inflammation of the mouth
• tearing of the eyes
• tingling of the hands or feet
• trembling
• troubled breathing
• unusual tiredness or weakness
• unusual weight gain or loss
• unusually warm skin
• vomiting

• Blurred vision
• burning, dry, or itching eyes
• discharge from the eyes or excessive tearing
• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• facial swelling
• headache
• hives
• noisy breathing
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• sweating
• swelling of the eye, eyelid, or inner lining of the eyelid
• tightness in the chest

• Chest discomfort
• painful breathing
• quick, shallow breathing
• slight fever

• Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, or warmth at the injection site
• large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also Warning section.

Diarrhea, nausea, vomiting, tiredness, constipation, abdominal pain, and growth of eyelashes may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: swelling ankles/feet, unusual weakness, irregular heartbeat, severe muscle spasms, mouth sores, eye redness/itching/irritation, watery eyes, vision changes, menstrual changes.

Prolonged and/or severe diarrhea may lead to a loss of too much body water and minerals (dehydration). Tell your doctor right away if you develop any of the following: extreme thirst, decreased urination, dizziness, fainting.

Rarely, panitumumab has caused very serious lung disease. Tell your doctor right away if you develop symptoms of lung disease, including: cough, shortness of breath.

Get medical help right away if you have any very serious side effects, including: seizures.

Rarely, panitumumab has caused very serious infusion reactions, including an allergic reaction. Get medical help right away if you develop fever, chills, or symptoms of an allergic reaction.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Before receiving panitumumab, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: lung disease (e.g., pulmonary fibrosis, interstitial pneumonitis), low magnesium/calcium blood levels.

Sunlight may worsen any skin reactions that may occur while you are receiving this drug. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors.

Tell your doctor if you are pregnant or plan to become pregnant. You should not become pregnant while using panitumumab. Panitumumab may harm an unborn baby. Ask about reliable forms of birth control while using this medication and for 2 months after stopping treatment. If you become pregnant, talk to your doctor right away about the risks and benefits of this medication.

Based on information from related drugs, this medication may pass into breast milk. Therefore, breast-feeding is not recommended while using this medication and for 2 months after the end of treatment. Consult your doctor before breast-feeding.

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Notes

Certain laboratory tests may be performed before giving panitumumab to check for the EGFR protein in your tumor.

Laboratory and/or medical tests (such as magnesium/calcium levels) should be performed before you start treatment, periodically during treatment and for 8 weeks after completion of treatment to monitor your progress or check for side effects. Consult your doctor for more details.

Missed Dose

For the best possible benefit, it is important to receive each scheduled dose of this medication as directed. If you miss a dose, contact your doctor to establish a new dosing schedule.

Storage

Not applicable. This medication is given in a clinic and will not be stored at home.Information last revised August 2017. Copyright(c) 2017 First Databank, Inc.