Pantoprazole Intravenous

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

• Accumulation of pus
• bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
• changes in skin color
• fever
• pain, tenderness, or swelling of the foot or leg
• stomach pain
• swollen, red, tender area of infection

• Drowsiness
• loss of appetite
• mood or mental changes
• muscle spasms (tetany) or twitching
• nausea or vomiting
• seizures
• trembling
• unusual tiredness or weakness

• Abdominal or stomach tenderness
• absence of or decrease in body movement
• blindness
• blistering, peeling, or loosening of the skin
• bloating of the abdomen or stomach
• bloody or cloudy urine
• bloody, black, or tarry stools
• blurred vision
• chills
• constipation
• continuing ringing or buzzing or other unexplained noise in the ears
• cough
• dark-colored urine
• decreased vision
• diarrhea
• difficulty with speaking
• difficulty with swallowing
• dizziness or lightheadedness
• fast heartbeat
• feeling of constant movement of self or surroundings
• greatly decreased frequency of urination or amount of urine
• hearing loss
• hives, itching, or rash
• increased watering of the mouth
• indigestion
• joint or muscle pain
• large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
• light-colored stools
• muscle cramps, pain, or stiffness
• pains in the stomach, side, or abdomen, possibly radiating to the back
• pale skin
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• red skin lesions, often with a purple center
• red, irritated eyes
• sensation of spinning
• severe abdominal or stomach cramps or pain
• sore throat
• sores, ulcers, or white spots on the lips or in the mouth
• swelling of the feet or lower legs
• swollen glands
• tightness in the chest
• unexplained bleeding or bruising
• watery and severe diarrhea, which may also be bloody
• yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Headache

• Acid or sour stomach
• belching
• dizziness
• excess air or gas in the stomach or intestines
• full feeling
• passing gas

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Notes

Do not share this medication with others.

Laboratory and/or medical tests may be performed periodically to monitor your progress or check for side effects.

Missed Dose

If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Storage

Store vials at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.Information last revised November 2016. Copyright(c) 2016 First Databank, Inc.

Pantoprazole is a proton pump inhibitor that decreases the amount of acid produced in the stomach.

Pantoprazole is used to treat erosive esophagitis (damage to the esophagus from stomach acid), and other conditions involving excess stomach acid such as Zollinger-Ellison syndrome.

Pantoprazole is not for immediate relief of heartburn symptoms.

More frequently reported side effects include: diarrhea and nausea. See below for a comprehensive list of adverse effects.

Oral: 40 mg orally once a day
-Duration of therapy: 8 weeks

Parenteral: 40 mg IV once a day, given over at least 2 minutes OR over 15 minutes
-Duration of therapy: 7 to 10 days

Comments:
-IV treatment should be discontinued once the patient is able to take an oral formulation.
-Use of the IV formulation has not been studied for longer than 10 days.
-If patients are not healed after 8 weeks with the oral formulation, treatment for another 8 weeks may be considered.

Uses:
-Short-term treatment of gastroesophageal reflux disease (GERD) in patients with a history of erosive esophagitis
-Reduction of relapse rates of daytime and nighttime heartburn symptoms in adult patients with GERD

5 years and older:
15 to less than 40 kg: 20 mg orally once a day
40 kg and greater: 40 mg orally once a day
Duration of therapy: Up to 8 weeks

Comment: Safety has not been established in treatment beyond 8 weeks.

Uses:
-Short-term treatment in the healing and symptomatic relief of erosive esophagitis
-Short-term treatment of GERD in patients with a history of erosive esophagitis

• Effective at healing erosive esophagitis (a severe inflammation of the lining of the esophagus- the tube that carries food from the mouth to the stomach), and relieving symptoms of gastro-esophageal reflux disease (also known as heartburn).
• Useful in the treatment of hypersecretory conditions such as Zollinger-Ellison syndrome.
• Usually, only up to 8 weeks of treatment is required; although may be used for up to 12 months to maintain healing of erosive esophagitis.
• No dosage adjustment is needed in people with kidney or liver disease or in the elderly.
• Generic pantoprazole is available.

• Peak effects happen within two and a half hours and effects can last for over 24 hours.

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Use is not recommended and a decision should be made to discontinue breastfeeding or discontinue the drug, taking into account the importance of the drug to the mother. Excreted into human milk: Unknown Excreted into animal milk: Yes Comment: The effects in the nursing infant are unknown.

Animal models have evidence of decreased pup weight at doses of at least 10 mg/kg/day. There have been reports of excretion into human breast milk.

LactMed Record Number

409

Last Revision Date

20170905

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.