MicRhoGAM Ultra-Filtered Plus

You should not receive this medicine if you have ever had an allergic reaction to an immune globulin, or if you have:

• immune globulin A (IgA) deficiency with antibody to IgA; or

• hemolytic anemia (a lack of red blood cells).

To make sure RHo (D) immune globulin is safe for you, tell your doctor if you have:

• a history of anemia;

• heart disease or a history of coronary artery disease (hardened arteries);

• a bleeding disorder (such as hemophilia);

• high triglycerides (a type of fat in the blood);

• kidney disease; or

• diabetes.

RHo (D) immune globulin is often used during and after pregnancy. This medicine is not known to be harmful to a baby during pregnancy or while breast-feeding.

If you are receiving this medication to treat a mismatched blood transfusion, tell your doctor if you are pregnant or if you ever plan to become pregnant.

If you are an Rh-negative woman and you become pregnant, you must tell your doctor if you have ever been exposed to Rh-positive blood in your lifetime. This includes exposure from a mismatched blood transfusion, or exposure during your first pregnancy. Your history of exposure and treatment will be extremely important to each and every one of your pregnancies.

RHo (D) immune globulin is made from human plasma (part of the blood) which may contain viruses and other infectious agents. Donated plasma is tested and treated to reduce the risk of it containing infectious agents, but there is still a small possibility it could transmit disease. Talk with your doctor about the risks and benefits of using this medication.

Do not receive a "live" vaccine for at least 3 months after treatment with RHo (D) immune globulin. The vaccine may not work as well during this time, and may not fully protect you from disease. Live vaccines include measles, mumps, rubella (MMR), rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.

• It is used to treat Rh hemolytic disease.
• It is used to treat immune thrombocytopenia (ITP).
• It may be given to you for other reasons. Talk with the doctor.

For all patients taking this medicine:

• If you have an allergy to Rho(D) immune globulin or any other part of this medicine (MICRhoGAM Ultra-Filtered Plus).
• If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
• If you have any of these health problems: Anemia, other blood or bleeding problems, or you have had your spleen removed.
• If you have IgA deficiency.
• If you have recently had a live vaccine

Children:

• If your child is a newborn. Some brands of this medicine are not for use in newborns.

This is not a list of all drugs or health problems that interact with this medicine (MICRhoGAM Ultra-Filtered Plus).

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this medicine with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
• Back pain.
• Belly pain.
• Blood in the urine.
• Dark urine or yellow skin or eyes.
• Not able to pass urine or change in how much urine is passed.
• Upset stomach or throwing up.
• Shortness of breath, a big weight gain, or swelling in the arms or legs.
• Feeling very tired or weak.
• Fever or chills.
• Change in color of urine.
• Very bad dizziness or passing out.
• Very bad headache.
• Fast breathing.
• Pale skin.
• Any unexplained bruising or bleeding.

• If your symptoms or health problems do not get better or if they become worse, call your doctor.
• Do not share your drugs with others and do not take anyone else's drugs.
• Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
• Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
• Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
• Check with your pharmacist about how to throw out unused drugs.
• Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about this medicine, please talk with your doctor, nurse, pharmacist, or other health care provider.
• If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Review Date: October 4, 2017