Lincomycin

Lincomycin may be found in some form under the following brand names:

• Bactramycin

• L-Mycin

• Linco-Jec

• Lincocin

• Lincomed

• Lincomix

• Lincorex

Lincomycin is available in the following forms:

• Injectable Solution
• Oral Capsule
• Oral Solution

Lincomycin is an antibiotic that fights bacteria.

Lincomycin is used to treat severe bacterial infections in people who cannot use penicillin antibiotics.

Lincomycin is used only for a severe infection. This medicine will not treat a viral infection such as the common cold or flu.

Lincomycin may also be used for purposes not listed in this medication guide.

• If you have an allergy to lincomycin, clindamycin, or any other part of this medicine.
• If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
• If you are using any products that have erythromycin.

This is not a list of all drugs or health problems that interact with lincomycin.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this medicine with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

The intramuscular administration to swine may cause a transient diarrhea or loose stools. Although this effect has rarely been reported, one must be alert to the possibility that it may occur. Should this occur, it is important that the necessary steps be taken to prevent the effects of dehydration.

For arthritis or mycoplasma pneumonia-5 mg per pound of body weight intramuscularly once daily for three to seven days as needed. When using Lincomycin Injectable containing 25 mg/mL,
1 mL/5 lb. body weight will provide 5 mg/lb. When using Lincomycin Injectable containing 100 mg/mL, 1 mL/20 lb body weight will provide 5 mg/lb. When using Lincomycin Injectable containing 300 mg/mL, 1 mL/60 lb. body weight will provide 5 mg/lb.

Mild to moderate impairment: There are no dosage adjustments provided in the manufacturer’s labeling.

Severe impairment: Use with caution; decrease dose by 70% to 75%.

End stage renal disease (ESRD) on hemodialysis: There are no dosage adjustments provided in the manufacturer’s labeling; use with caution; not removed by hemodialysis.

Peritoneal dialysis: There are no dosage adjustments provided in the manufacturer’s labeling; use with caution; not removed by peritoneal dialysis.

Concerns related to adverse effects:

• Colitis: [US Boxed Warning]: C. difficile-associated diarrhea (CDAD) has been reported. May range in severity from mild to severe (and possibly fatal). Lincomycin therapy should be reserved for serious infections for which less toxic antimicrobial agents are inappropriate. It should not be used in patients with nonbacterial infections, such as most upper respiratory tract infections. CDAD has been observed more than 2 months postantibiotic treatment.

• Hypersensitivity reactions: Hypersensitivity reactions, including anaphylaxis and erythema multiforme, have been reported. Discontinue use if allergic reaction occurs.

• Superinfection: Prolonged use may result in bacterial or fungal superinfection, particularly yeasts. Concomitant antimonilial infection treatment should be given in patients with preexisting monilial infections.

Disease-related concerns:

• Allergies: Use with caution in patients with significant allergies.

• Asthma: Use with caution in patients with a history of asthma.

• Gastrointestinal disease: Use with caution in patients with a history of gastrointestinal disease (particularly colitis).

• Hepatic impairment: Use with caution in patients with hepatic impairment; half-life may be prolonged 2-fold.

• Renal impairment: Use with caution in patients with renal impairment; half-life may be prolonged; dosage adjustment necessary with severe impairment.

Concurrent drug therapy concerns:

• Drug-drug interactions: Potentially significant interactions may exist, requiring dose or frequency adjustment, additional monitoring, and/or selection of alternative therapy. Consult drug interactions database for more detailed information.

Special populations:

• Elderly: Use with caution in the elderly; monitor closely for bowel changes.

Dosage form specific issues:

• Benzyl alcohol and derivatives: Some dosage forms may contain benzyl alcohol; large amounts of benzyl alcohol (≥99 mg/kg/day) have been associated with a potentially fatal toxicity ("gasping syndrome") in neonates; the "gasping syndrome" consists of metabolic acidosis, respiratory distress, gasping respirations, CNS dysfunction (including convulsions, intracranial hemorrhage), hypotension, and cardiovascular collapse (AAP ["Inactive" 1997]; CDC 1982); some data suggest that benzoate displaces bilirubin from protein binding sites (Ahlfors, 2001); avoid or use dosage forms containing benzyl alcohol with caution in neonates. See manufacturer’s labeling.

Other warnings/precautions:

• Administration: Do not use undiluted as an IV bolus.

• Appropriate use: Generally reserved for use when treatment with other antibiotics is inappropriate. Not appropriate for use in the treatment of meningitis due to inadequate penetration into the cerebrospinal fluid.

Change in bowel frequency or consistency (eg, diarrhea); baseline serum creatinine and liver function tests (LFTs); periodically during prolonged therapy: renal function and LFTs, complete blood cell count (CBC) with differential

Consult your pharmacist.

How to use Lincomycin Powder

Consult your pharmacist.

Consult your pharmacist.

Over 1 month of age:
IM:
Serious infections: 10 mg/kg IM every 24 hours
More severe infections: 10 mg/kg IM every 12 hours or more often

IV: 10 to 20 mg/kg IV per day, in divided doses (as for adults)

Comments:
-Dose should be based on the severity of the infection.
-This drug should be reserved for penicillin-allergic patients or patients for whom a penicillin is considered inappropriate.

Uses: Treatment of serious infections due to susceptible strains of streptococci, pneumococci, and staphylococci