Lodoxamide Ophthalmic

Ophthalmic lodoxamide is used to treat redness, burning, itching, and swelling of the eyes that is caused by allergic reactions. Lodoxamide is in a class of medications called mast cell stabilizers. It works by preventing allergic reactions.

• Alomide^®

Do not touch the dropper to any surface, including your eyes or hands. The dropper is sterile. If it becomes contaminated, it could cause an infection in your eye.

Do not use any other eye medications unless your doctor has prescribed them.

It is not likely that other drugs you take orally or inject will have an effect on lodoxamide ophthalmic. But many drugs can interact with each other. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

Use this medication exactly as prescribed by your doctor. Do not use it in larger amounts or for longer than recommended. Follow the directions on your prescription label.

Do not use lodoxamide while you are wearing contact lenses. This medication may contain a preservative that can be absorbed by soft contact lenses and cause discoloration. Wait at least 15 minutes after using lodoxamide before putting your contact lenses in.

Wash your hands before using the eye drops.

To apply the eye drops:

• Tilt your head back slightly and pull down your lower eyelid to create a small pocket. Hold the dropper above the eye with the dropper tip down. Look up and away from the dropper as you squeeze out a drop, then close your eye.
• Gently press your finger to the inside corner of the eye (near your nose) for about 1 minute to keep the liquid from draining into your tear duct. If you use more than one drop in the same eye, wait about 5 minutes before putting in the next drop.
• Do not allow the dropper tip to touch any surface, including the eyes or hands. If the dropper becomes contaminated it could cause an infection in your eye, which can lead to vision loss or serious damage to the eye.

Do not use the eye drops if the liquid has changed colors or has particles in it. Call your doctor for a new prescription.

Store the drops at cool room temperature away from heat and moisture. Keep the bottle tightly closed when not in use.

Seek emergency medical attention if you think you have used too much of this medicine.

An overdose of lodoxamide ophthalmic applied to the eyes is not likely to occur.

Use the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up the missed dose.

Mechanism of Action

Lodoxamide tromethamine is a mast cell stabilizer that inhibits the in vivo Type I immediate hypersensitivity reaction; inhibits the increases in cutaneous vascular permeability associated with IgE and antigen-mediated reactions

Half-Life

8.5 hrs

Absorption

Systemic absorption minimal

Excretion

Primarily in urine

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using lodoxamide and call your doctor at once if you have severe burning or stinging when you apply the eye drops, or for long periods of time after using the drops.

Less serious side effects may include:

• mild burning, stinging, or eye irritation;

• eye itching, watering, pain, or redness;

• blurred vision;

• dry eyes;

• swollen or puffy eye lids;

• feeling that something is in your eye; or

• crusting or drainage from your eyes.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

No adjustment recommended