Ketoconazole (Oral Route)

Ketoconazole is used to treat serious fungal or yeast infections, such as candidiasis (thrush, oral thrush), blastomycosis (Gilchrist's disease), coccidioidomycosis (Valley fever, San Joaquin Valley fever), histoplasmosis (Darling's disease), chromoblastomycosis (chromomycosis), or paracoccidioidomycosis (South American blastomycosis, Lutz-Splendore-Almeida disease). This medicine works by killing the fungus or yeast, or preventing its growth.

Ketoconazole is also used to treat parasitic fungal infections on the skin (such as athlete's foot or ringworm) that cannot be treated with topical medicine or griseofulvin, or for patients who cannot take griseofulvin.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

• Tablet

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Alfuzosin
• Alprazolam
• Amifampridine
• Amiodarone
• Amisulpride
• Artemether
• Astemizole
• Atazanavir
• Bedaquiline
• Bepridil
• Cisapride
• Citalopram
• Clarithromycin
• Clozapine
• Colchicine
• Conivaptan
• Crizotinib
• Dabrafenib
• Dihydroergotamine
• Disopyramide
• Dofetilide
• Domperidone
• Donepezil
• Dronedarone
• Eletriptan
• Eplerenone
• Ergoloid Mesylates
• Ergonovine
• Ergotamine
• Felodipine
• Flibanserin
• Fluconazole
• Halofantrine
• Iloperidone
• Irinotecan
• Irinotecan Liposome
• Isavuconazonium Sulfate
• Ivabradine
• Lomitapide
• Lopinavir
• Lovastatin
• Lumefantrine
• Lurasidone
• Maraviroc
• Mefloquine
• Mesoridazine
• Methadone
• Methylergonovine
• Methysergide
• Midazolam
• Mifepristone
• Naloxegol
• Nimodipine
• Nisoldipine
• Ondansetron
• Panobinostat
• Pazopanib
• Pimavanserin
• Pimozide
• Piperaquine
• Pitolisant
• Propafenone
• Quinidine
• Quinine
• Ranolazine
• Saquinavir
• Silodosin
• Simvastatin
• Solifenacin
• Sorafenib
• Sparfloxacin
• Sunitinib
• Tamoxifen
• Telaprevir
• Terfenadine
• Thioridazine
• Tolvaptan
• Toremifene
• Trazodone
• Triazolam
• Vandetanib
• Vemurafenib
• Venetoclax
• Vilanterol
• Vinflunine
• Ziprasidone

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Ado-Trastuzumab Emtansine
• Afatinib
• Alfentanil
• Aluminum Carbonate, Basic
• Aluminum Hydroxide
• Aluminum Phosphate
• Amitriptyline
• Anagrelide
• Apixaban
• Apomorphine
• Aprepitant
• Aripiprazole
• Arsenic Trioxide
• Asenapine
• Atorvastatin
• Avanafil
• Axitinib
• Azithromycin
• Boceprevir
• Bosutinib
• Bretylium
• Brexpiprazole
• Bromocriptine
• Buserelin
• Busulfan
• Cabazitaxel
• Cabozantinib
• Calcifediol
• Calcium
• Calcium Carbonate
• Carbamazepine
• Cariprazine
• Ceritinib
• Cerivastatin
• Chloroquine
• Chlorpromazine
• Cilostazol
• Cimetidine
• Ciprofloxacin
• Clomipramine
• Clonazepam
• Clopidogrel
• Cobicistat
• Cobimetinib
• Cyclobenzaprine
• Dabigatran Etexilate
• Daclatasvir
• Dasabuvir
• Dasatinib
• Degarelix
• Delavirdine
• Desipramine
• Deslorelin
• Dexlansoprazole
• Dihydroxyaluminum Aminoacetate
• Dihydroxyaluminum Sodium Carbonate
• Docetaxel
• Dolasetron
• Doxepin
• Doxorubicin
• Doxorubicin Hydrochloride Liposome
• Droperidol
• Ebastine
• Efavirenz
• Elvitegravir
• Enzalutamide
• Eribulin
• Erlotinib
• Erythromycin
• Esomeprazole
• Eszopiclone
• Etravirine
• Everolimus
• Famotidine
• Felbamate
• Fentanyl
• Fingolimod
• Flecainide
• Fluoxetine
• Fluticasone
• Fosaprepitant
• Foscarnet
• Fosphenytoin
• Gatifloxacin
• Gemifloxacin
• Gonadorelin
• Goserelin
• Granisetron
• Grazoprevir
• Haloperidol
• Histrelin
• Hydrocodone
• Hydroquinidine
• Hydroxychloroquine
• Hydroxyzine
• Ibrutinib
• Ibutilide
• Idelalisib
• Ifosfamide
• Imatinib
• Indinavir
• Isoniazid
• Ivacaftor
• Ixabepilone
• Lansoprazole
• Lapatinib
• Leuprolide
• Levofloxacin
• Levomethadyl
• Levomilnacipran
• Lumacaftor
• Macitentan
• Magaldrate
• Magnesium Carbonate
• Magnesium Hydroxide
• Magnesium Oxide
• Magnesium Trisilicate
• Manidipine
• Metronidazole
• Mitotane
• Mizolastine
• Morphine
• Morphine Sulfate Liposome
• Moxifloxacin
• Nafarelin
• Nefazodone
• Nelfinavir
• Nevirapine
• Nifedipine
• Nilotinib
• Nizatidine
• Norfloxacin
• Octreotide
• Olanzapine
• Olaparib
• Ombitasvir
• Omeprazole
• Ospemifene
• Oxycodone
• Paclitaxel
• Palbociclib
• Paliperidone
• Pantoprazole
• Paritaprevir
• Paroxetine
• Pasireotide
• Pentamidine
• Perphenazine
• Phenytoin
• Pixantrone
• Ponatinib
• Probucol
• Procainamide
• Promethazine
• Protriptyline
• Quetiapine
• Rabeprazole
• Ranitidine
• Reboxetine
• Regorafenib
• Retapamulin
• Rifabutin
• Rifampin
• Rifapentine
• Risperidone
• Ritonavir
• Rivaroxaban
• Romidepsin
• Roxatidine
• Ruxolitinib
• Salmeterol
• Sertindole
• Sevoflurane
• Simeprevir
• Sirolimus
• Sodium Bicarbonate
• Sodium Phosphate
• Sodium Phosphate, Dibasic
• Sodium Phosphate, Monobasic
• Sonidegib
• Sotalol
• St John's Wort
• Sucralfate
• Sulpiride
• Suvorexant
• Tacrolimus
• Tadalafil
• Tamsulosin
• Telavancin
• Telithromycin
• Temsirolimus
• Tetrabenazine
• Ticagrelor
• Tipranavir
• Tizanidine
• Tolterodine
• Topotecan
• Trabectedin
• Trimetrexate
• Trimipramine
• Triptorelin
• Vardenafil
• Venlafaxine
• Verapamil
• Vilazodone
• Vinblastine
• Vincristine
• Vincristine Sulfate Liposome
• Vinorelbine
• Vorapaxar
• Vorinostat
• Warfarin
• Zaleplon
• Zolpidem
• Zuclopenthixol

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Acenocoumarol
• Alitretinoin
• Almotriptan
• Alosetron
• Amprenavir
• Anisindione
• Bexarotene
• Bortezomib
• Bosentan
• Budesonide
• Chlordiazepoxide
• Cinacalcet
• Clobazam
• Conjugated Estrogens
• Cyclosporine
• Darifenacin
• Darunavir
• Dicumarol
• Didanosine
• Dutasteride
• Esterified Estrogens
• Estradiol
• Estriol
• Estrone
• Estropipate
• Fesoterodine
• Fosamprenavir
• Galantamine
• Isradipine
• Methylprednisolone
• Mometasone
• Nicardipine
• Oxybutynin
• Parecoxib
• Paricalcitol
• Phenprocoumon
• Pioglitazone
• Praziquantel
• Prednisone
• Ramelteon
• Repaglinide
• Roflumilast
• Sildenafil
• Tolbutamide
• Tretinoin
• Valdecoxib

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Achlorhydria (absence of stomach acid)—May not be absorbed from the stomach in patients with this condition.

• Adrenal problems or
• Heart disease, history of or
• Heart rhythm problems (eg, QT prolongation), or history of—These conditions may cause side effects to become worse.

• Liver disease, acute or chronic—Should not be used in patients with this condition.