Hydase

Dosage Forms And Strengths

Injection 150 USP Units/mL single dose vials.

Storage And Handling

Hydase™ (hyaluronidase injection) Bovine is supplied sterile as 150 units/mL bovine of hyaluronidase in a single-dose glass vial containing 1 mL.

NDC 17478-560-01 Package of 1 vial.
NDC 17478-560-06 Package of 6 vials.
NDC 17478-560-10 Package of 10 vials.

Not recommended for IV Use.

Store in a refrigerator at 2° to 8°C (36° to 46°F).

DO NOT FREEZE.

Manufactured by: Akorn, Inc. Lake Forest, IL 60045. Revised: Oct 2015

The most frequently reported adverse experiences have been local injection site reactions.

Hyaluronidase has been reported to enhance the adverse events associated with co-administered drug products. Edema has been reported most frequently in association with hypodermoclysis.

Allergic reactions (urticaria, angioedema) have been reported in less than 0.1% of patients receiving hyaluronidase. Anaphylactic-like reactions following retrobulbar block or intravenous injections have occurred, rarely.

Symptoms of toxicity consist of local edema or urticaria, erythema, chills, nausea, vomiting, dizziness, tachycardia, and hypotension. The enzyme should be discontinued and supportive measures initiated immediately.

Your doctor will check your progress closely while you are receiving this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it.

This medicine is made from donated human blood products. Some human blood products have transmitted viruses to people who have received them, although the risk is low. Human donors and donated blood are both tested for viruses to keep the transmission risk low. Talk with your doctor about this risk if you are concerned.

Some people may be allergic to this medicine. Tell your doctor if you develop a rash, hives, red or itching skin, or troubled breathing after you receive hyaluronidase.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.