Garamycin

Yes

Gentamicin is an antibiotic that fights bacteria.

Gentamicin is used to treat severe or serious bacterial infections.

Gentamicin may also be used for purposes not listed in this medication guide.

Gentamicin can harm your kidneys, and may also cause nerve damage or hearing loss, especially if you have kidney disease or use certain other medicines.

Tell your doctor about all your medical conditions and all the medicines you are using. If you need surgery, tell the surgeon ahead of time that you are using gentamicin.

Gentamicin can harm your kidneys. This effect is increased when you also use certain other medicines, including: antivirals, chemotherapy, injected antibiotics, medicine for bowel disorders, medicine to prevent organ transplant rejection, injectable osteoporosis medication, and some pain or arthritis medicines (including aspirin, Tylenol, Advil, and Aleve).

Tell your doctor about all your current medicines and any you start or stop using, especially:

• a diuretic or "water pill"; or

• any other antibiotic.

This list is not complete. Other drugs may interact with gentamicin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

1.5 to 2 mg/kg loading dose, followed by 1 to 1.7 mg/kg IV or IM every 8 hours, or 5 to 7 mg/kg IV every 24 hours
Duration of therapy: 7 to 21 days, depending on the nature and severity of the infection

Comments: Limiting the duration of gentamicin therapy may help limit toxicity. Once the patient is stable for at least 48 hours, less toxic IV or oral antibiotic therapy may be considered according to microbiology sensitivity data.

2 to 2.5 mg/kg loading dose, followed by 1.7 to 2 mg/kg IV every 8 hours
Duration of therapy: 10 to 14 days, depending on the nature and severity of the infection

1.5 to 2 mg/kg loading dose, followed by 1 to 1.7 mg/kg IV or IM every 8 hours or 5 to 7 mg/kg IV every 24 hours
Duration of therapy: 4 to 6 weeks, depending on the nature and severity of the infection; chronic osteomyelitis may require an additional 1 to 2 months of oral antibiotics

Comments: Limiting the duration of gentamicin therapy may help limit toxicity. Once the patient is stable for at least 48 hours, less toxic IV or oral antibiotic therapy may be considered according to microbiology sensitivity data.

0 to 4 weeks, birthweight <1200 g: 2.5 mg/kg IV or IM every 18 to 24 hours
0 to 1 week, birthweight >=1200 g: 2.5 mg/kg IV or IM every 12 hours
1 to 4 weeks, birthweight 1200 to 2000 g: 2.5 mg/kg IV or IM every 8 to 12 hours
1 to 4 weeks, birthweight >=2000 g: 2.5 mg/kg IV or IM every 8 hours

>1 month: 1 to 2.5 mg/kg IV or IM every 8 hours

2 mg/kg IV once at induction of anesthesia

No adjustment recommended.

Animal studies have failed to reveal evidence of teratogenicity; however, nephrotoxicity occurred in fetal rats. There are no controlled data in human pregnancy. If gentamicin is used during pregnancy or if a woman becomes pregnant during therapy, she should be advised of the potential risk to the fetus. Aminoglycosides can cause fetal harm when given to pregnant women. Aminoglycosides cross the placenta and there are reports of fetal eighth cranial nerve toxicity with permanent bilateral deafness after in utero exposure to streptomycin. Serious side effects to mother, fetus, or newborn have not been reported in pregnant women treated with other aminoglycosides. FDA pregnancy category D: There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

FDA pregnancy category: D Safety of gentamicin has not been established; potential benefit should outweigh the potential risk.