Femara letrozole vs Clomid clomiphene

• Femara (letrozole) and Clomid (clomiphene) are fertility medications used for stimulating ovulation.
• Femara is an anti-estrogen drug typically used for treating postmenopausal women with breast cancer.
• Side effects of Femara and Clomid that are similar include nausea, vomiting, headache, and muscle aches or pains.
• Side effects of Femara that are different from Clomid include fatigue, diarrhea, constipation, chest pain, increased cholesterol levels, and decreased bone mineral density (which increases the risk of osteoporosis and bone fractures).
• Side effects of Clomid that are different from Femara include ovarian enlargement, flushing (warmth, redness, or tingly feeling), stomach discomfort, breast discomfort, blurred vision, abnormal heart beats, acne, allergic reactions, and uterine bleeding.

Femara

The most common side effects with letrozole are:

• nausea,
• vomiting,
• fatigue,
• headache,
• muscle aches,
• diarrhea,
• constipation, and
• chest pain.

Cholesterol levels may increase during letrozole therapy. Cholesterol levels should be monitored and some patients may require treatment for high cholesterol levels. Letrozole decreases bone mineral density, increasing the risk of osteoporosis and fractures.

Clomid

The most common side effects of clomiphene are:

• ovarian enlargement,
• flushing,
• stomach discomfort,
• breast discomfort,
• blurred vision,
• nausea, and
• vomiting.

Other important side effects include

• abnormal heart beats,
• acne,
• allergic reactions,
• headaches,
• uterine bleeding,
• back pain, and
• muscle pain.

Femara

Tamoxifen reduces blood levels of letrozole when both drugs are administered together. However, in clinical studies the benefit of letrozole was not reduced when administered immediately after tamoxifen. Letrozole is an anti-estrogen drug. Therefore, estrogen containing products counteract the effect of letrozole.

Clomid

No drug interactions are listed in the prescribing information.

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Femara

Letrozole damages the fetus. It should not be taken by pregnant women. It is not known if letrozole is secreted into breast milk.

Clomid

Clomiphene should not be taken by pregnant women since it does not offer any benefit to pregnant women.

It is not known whether clomiphene is excreted into breast milk. It may reduce lactation in some women.

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