Netarsudil

Use netarsudil as ordered by your doctor. Read all information given to you. Follow all instructions closely.

• For the eye only.
• Use as you have been told, even if your signs get better.
• Use in the evening.
• Take out contact lenses before using netarsudil. Lenses may be put back in 15 minutes after netarsudil is given. Do not put contacts back in if your eyes are irritated or infected.
• Do not touch the container tip to the eye, lid, or other skin.
• If more than 1 drug is being used in the same eye, use each drug at least 5 minutes apart.

What do I do if I miss a dose?

• Skip the missed dose and go back to your normal time.
• Do not use 2 doses at the same time or extra doses.

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
• Change in eyesight, eye pain, or very bad eye irritation.

• Store unopened containers in a refrigerator. Do not freeze.
• After opening, store at room temperature or in a refrigerator. Throw away any part not used after 6 weeks.
• Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
• Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

Applies to netarsudil ophthalmic: ophthalmic solution

General

The most frequently reported side effects were conjunctival hyperemia, corneal verticillata, instillation site pain, and conjunctival hemorrhage.[Ref]

Ocular

Very common (10% or more): Conjunctival hyperemia (53%), corneal verticillata (20%), instillation site pain (up to 20%), conjunctival hemorrhage (up to 20%)
Common (1% to 10%): Instillation site erythema, corneal staining, blurred vision, lacrimation increased, erythema of eyelid, visual acuity reduced[Ref]

Some side effects of netarsudil ophthalmic may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

The manufacturer makes no recommendation regarding use during pregnancy.

US FDA pregnancy category: Not assigned.

Risk Summary: No data available on use of this drug in pregnant women to inform a drug-related risk.

Comments: Systemic absorption is low following ocular administration.

Animal studies have not been reported. Animal studies with the IV formulation to pregnant rats and rabbits during organogenesis did not produce adverse embryofetal effects at clinically relevant systemic exposures. When administered IV at higher doses, abortions, embryofetal lethality, and decreased fetal weight were observed. There are no controlled data in human pregnancy.

US FDA pregnancy category Not Assigned: The US FDA has amended the pregnancy labeling rule for prescription drug products to require labeling that includes a summary of risk, a discussion of the data supporting that summary, and relevant information to help health care providers make prescribing decisions and counsel women about the use of drugs during pregnancy. Pregnancy categories A, B, C, D, and X are being phased out.

The manufacturer makes no recommendation regarding use during lactation.

Excreted into human milk: Unknown
Excreted into animal milk: Data not available

Comments:
-Systemic exposure to this drug is low following topical ocular administration and it is unknown whether measurable levels would be present in maternal milk.
-Developmental and health benefits of breastfeeding should be considered as well as the mother's clinical need for this drug.
-Potential side effects in the breastfed child due to the drug or the mother's underlying condition should be considered.