Estrace (Estradiol Vaginal Cream)

Use this medicine as ordered by your doctor. Read all information given to you. Follow all instructions closely.

• Use Estrace at the same time of day.
• Follow how to use as you have been told by the doctor or read the package insert.
• Wash your hands before use.
• Wash your hands and applicator after use.
• There may be days when you will not take this medicine.

What do I do if I miss a dose?

• Use a missed dose as soon as you think about it.
• If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
• Do not use 2 doses at the same time or extra doses.

Applies to estradiol topical: vaginal cream, vaginal ring, vaginal tablet

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

• Headache.
• Hair loss.
• Breast soreness.
• Upset stomach or throwing up.
• Cramps.
• Bloating.
• Vaginal bleeding or spotting.
• Vaginal irritation.
• This drug may cause dark patches of skin on your face. Avoid sun, sunlamps, and tanning beds. Use sunscreen and wear clothing and eyewear that protects you from the sun.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.