Estradiol Vaginal Ring (Estring)

• It is used to treat vaginal irritation and dryness caused by change of life.
• It is used to treat urinary signs caused by change of life.
• It may be given to you for other reasons. Talk with the doctor.

Use this medicine as ordered by your doctor. Read all information given to you. Follow all instructions closely.

• Follow how to use as you have been told by the doctor or read the package insert.
• Wash your hands before use.
• Put into the vagina and leave in place for 90 days.
• To use, wash your hands and take ring from the pouch.
• Be sure your hands are dry before you touch estradiol vaginal ring.
• Press sides of ring at the same time between thumb and index finger and put folded ring into the vagina.
• Perfect placement is not needed for the ring to work. The ring will not hurt.
• If the ring comes out, rinse with lukewarm water and put back in.
• To take out, hook your index finger around the rim or hold rim between index finger and middle finger and pull out.
• Do not throw the vaginal ring in the toilet.
• Wash your hands after use.

What do I do if I miss a dose?

• Use a missed dose as soon as you think about it.
• If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
• Do not use 2 doses at the same time or extra doses.

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
• Signs of gallbladder problems like pain in the upper right belly area, right shoulder area, or between the shoulder blades; change in stools; dark urine or yellow skin or eyes; or fever with chills.
• Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
• Chest pain or pressure.
• Shortness of breath.
• Coughing up blood.
• Swelling, warmth, numbness, change of color, or pain in a leg or arm.
• Very bad headache.
• Very bad dizziness or passing out.
• Weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or blurred eyesight.
• Very upset stomach or throwing up.
• Very bad belly pain.
• Pelvic pain or pressure.
• Very bad vaginal irritation.
• Vaginal itching or discharge.
• Vaginal bleeding that is not normal.
• A lump in the breast, breast soreness, or nipple discharge.
• Breast pain.
• Low mood (depression).
• Mood changes.
• Memory problems or loss.
• Bulging eyes.
• Change in how contact lenses feel in the eyes.
• Change in eyesight.
• Loss of eyesight.
• Swelling.

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

• Headache.
• Hair loss.
• Breast soreness.
• Upset stomach or throwing up.
• Cramps.
• Bloating.
• Vaginal bleeding or spotting.
• Vaginal irritation.
• This medicine may cause dark patches of skin on your face. Avoid sun, sunlamps, and tanning beds. Use sunscreen and wear clothing and eyewear that protects you from the sun.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.