Doxycycline Hyclate eent

Name: Doxycycline Hyclate eent

Uses for Doxycycline Hyclate

Periodontitis

Used orally as an adjunct to scaling and root planing to promote attachment-level gain and to reduce pocket depth in adults with periodontitis.14 15 16

Used subgingivally in treatment of chronic periodontitis in adults to reduce pocket depth, gain clinical attachment level, and reduce bleeding associated with probing.1 2 3 4 5 7 10 11

Interactions for Doxycycline Hyclate

Drug interactions reported involve oral doxycycline.14 No formal drug interaction studies have been performed with doxycycline hyclate polymer for subgingival administration.1

Specific Drugs

Drug

Interaction

Comments

Antacids (aluminum-, calcium-, or magnesium-containing)

Decreased doxycycline absorption14

Anticoagulants, oral

Possible decreased prothrombin activity14

Adjust anticoagulant dosage as needed14

Anticonvulsants (barbiturates, carbamazepine, phenytoin)

Possible decreased doxycycline half-life14

Bismuth subsalicylate

Possible decreased doxycycline absorption14

Hormonal contraceptives

Possible decreased effectiveness of oral contraceptives1 14

Iron-containing preparations

Possible decreased doxycycline absorption14

Methoxyflurane

Fatal renal toxicity reported with concomitant use of tetracycline and methoxyflurane14

Penicillins

Possible antagonism14

Avoid concomitant use14

Stability

Storage

Oral

Tablets

15–30°C in tight, light-resistant container.14

Subgingival

For liquid, extended-release polymer

2–8°C.1

Actions and Spectrum

  • Usually is bacteriostatic.1

  • Inhibits protein synthesis in susceptible organisms.1

  • Active in vitro at concentrations of ≤6 mcg/mL against Porphyromonas gingivalis, Prevotella intermedia, Campylobacter rectus, and Fusobacterium nucleatum.1

  • No evidence of doxycycline or multidrug resistance in subgingival plaque or saliva in a clinical study of 6 months’ duration of subgingival doxycycline hyclate.1 6

Advice to Patients

  • When taking doxycycline hyclate tablets, importance of drinking sufficient amounts of fluids to reduce the risk of esophageal irritation and ulceration.14

  • Doxycycline hyclate polymer for subgingival administration is not meant for self-administration; only qualified oral health-care professionals familiar with administration of the subgingival preparation should administer the drug.1

  • Importance of not using mechanical oral hygiene procedures (i.e., brushing teeth, flossing) for 7 days following administration of the subgingival preparation.1

  • Importance of avoiding exposure to direct sunlight or UV light while receiving oral or subgingival doxycycline hyclate; importance of notifying clinician and of discontinuing therapy at the first sign of skin erythema.1 13

  • Importance of women informing clinicians if they are or plan to become pregnant or plan to breast-feed.1

  • Importance of informing clinicians of existing or contemplated concomitant therapy, including prescription and OTC drugs, as well as any concomitant diseases.1

  • Importance of informing patients of other important precautionary information.1 (See Cautions.)

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