Docusate

• Dioctyl Calcium Sulfosuccinate
• Dioctyl Sodium Sulfosuccinate
• Docusate Calcium
• Docusate Potassium
• Docusate Sodium
• DOSS
• DSS

Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product

Capsule, Oral, as calcium:

Kao-Tin: 240 mg [sodium free; contains brilliant blue fcf (fd&c blue #1), fd&c red #40, fd&c yellow #6 (sunset yellow)]

Kao-Tin: 240 mg [DSC] [sodium free; contains fd&c red #40]

Stool Softener: 240 mg [contains brilliant blue fcf (fd&c blue #1), fd&c red #40, fd&c yellow #6 (sunset yellow)]

Stool Softener Laxative DC: 240 mg [DSC] [contains fd&c red #40]

Sur-Q-Lax: 240 mg [DSC]

Generic: 240 mg

Capsule, Oral, as sodium:

Colace: 50 mg [DSC]

Colace: 100 mg [contains fd&c red #40, fd&c yellow #6 (sunset yellow)]

Colace Clear: 50 mg [DSC] [dye free]

D.O.S.: 250 mg [DSC]

DocQLace: 100 mg [contains fd&c red #40, fd&c yellow #6 (sunset yellow)]

Docu Soft: 100 mg

Docusil: 100 mg

DOK: 100 mg [contains fd&c red #40, fd&c yellow #6 (sunset yellow)]

DOK: 250 mg [DSC]

DOK: 250 mg [contains fd&c red #40, fd&c yellow #6 (sunset yellow)]

Dulcolax Stool Softener: 100 mg [contains fd&c red #40, fd&c yellow #6 (sunset yellow)]

KS Stool Softener: 100 mg [stimulant free; contains brilliant blue fcf (fd&c blue #1), fd&c red #40, methylparaben, propylparaben, tartrazine (fd&c yellow #5)]

Laxa Basic: 100 mg

Sof-Lax: 100 mg

Stool Softener: 100 mg

Stool Softener: 100 mg, 250 mg [DSC] [contains fd&c red #40, fd&c yellow #6 (sunset yellow)]

Stool Softener: 100 mg [stimulant free; contains brilliant blue fcf (fd&c blue #1), fd&c red #40, fd&c yellow #6 (sunset yellow)]

Stool Softener: 100 mg, 250 mg [stimulant free; contains fd&c red #40, fd&c yellow #6 (sunset yellow)]

Generic: 100 mg, 250 mg

Enema, Rectal, as sodium:

DocuSol Kids: 100 mg/5 mL (5 ea) [contains polyethylene glycol]

DocuSol Mini: 283 mg (5 ea)

Enemeez Mini: 283 mg (5 mL)

Vacuant Mini-Enema: 283 mg (5 mL [DSC])

Liquid, Oral, as sodium:

Diocto: 50 mg/5 mL (473 mL [DSC]) [contains fd&c red #40, methylparaben, polyethylene glycol, propylene glycol, propylparaben; vanilla flavor]

Diocto: 50 mg/5 mL (473 mL) [contains parabens, polyethylene glycol]

Docu: 50 mg/5 mL (10 mL, 473 mL) [contains methylparaben, polyethylene glycol, propylene glycol, propylparaben, sodium benzoate; vanilla flavor]

Pedia-Lax: 50 mg/15 mL (118 mL) [contains edetate disodium, methylparaben, polyethylene glycol, propylene glycol, propylparaben; fruit punch flavor]

Silace: 150 mg/15 mL (473 mL) [lemon-vanilla flavor]

Generic: 50 mg/5 mL (10 mL)

Syrup, Oral, as sodium:

Diocto: 60 mg/15 mL (473 mL [DSC]) [contains fd&c red #40, menthol, methylparaben, polyethylene glycol, propylparaben, sodium benzoate; peppermint flavor]

Diocto: 60 mg/15 mL (473 mL [DSC]) [contains fd&c red #40, methylparaben, propylene glycol, propylparaben, sodium benzoate]

Diocto: 60 mg/15 mL (473 mL) [contains fd&c red #40, propylene glycol, saccharin sodium, sodium benzoate]

Silace: 60 mg/15 mL (473 mL) [contains alcohol, usp; peppermint flavor]

Generic: 60 mg/15 mL (25 mL)

Tablet, Oral, as sodium:

Docuprene: 100 mg [contains sodium benzoate]

DOK: 100 mg [scored]

Healthy Mama Move It Along: 100 mg [scored; stimulant free; contains sodium benzoate]

Promolaxin: 100 mg [scored; contains sodium benzoate]

Stool Softener: 100 mg [contains sodium benzoate]

Generic: 100 mg

Ceruminolytic

Data from a small, prospective, randomized, double-blind controlled study comparing the intra-aural use of docusate to triethanolamine polypeptide (not available in the US) and subsequent irrigation with lukewarm normal saline as needed supports the use of docusate intra-aurally as a ceruminolytic [Singer 2000]. Despite these data, the use of saline is still considered to be first-line [McCarter 2007]. Additional trials may be necessary to further define the role of intra-aural docusate in the treatment of this condition.

Refer to adult dosing.

There are no dosage adjustments provided in the manufacturer’s labeling

Some products may contain sodium.

Store at room temperature. Protect from freezing, heat humidity, and light.

1% to 10%: Respiratory: Throat irritation (liquid)

Dosage forms specific issues:

• Benzyl alcohol and derivatives: Some dosage forms may contain sodium benzoate/benzoic acid; benzoic acid (benzoate) is a metabolite of benzyl alcohol; large amounts of benzyl alcohol (≥99 mg/kg/day) have been associated with a potentially fatal toxicity (“gasping syndrome”) in neonates; the “gasping syndrome” consists of metabolic acidosis, respiratory distress, gasping respirations, CNS dysfunction (including convulsions, intracranial hemorrhage), hypotension and cardiovascular collapse (AAP 1997; CDC 1982); some data suggests that benzoate displaces bilirubin.

• Enema: For rectal use only; lubricate tip prior to insertion. Discontinue use and notify health care provider if rash around the anus/rectal irritation occurs or if resistance is encountered with insertion; forcing the tube may result in injury or damage to the rectum.

Other warnings/precautions:

• Self-medication (OTC use): When used for self-medication (OTC), patients should be instructed to contact healthcare provider prior to use if nausea, stomach pain, or vomiting are present, or if a sudden change in bowel habits occurs and persists over 14 days. Patients should discontinue use and notify healthcare provider if rectal bleeding occurs, if a bowel movement fails to occur after use, or if use is needed >7 days.