Dolasetron Oral, Intravenous

Name: Dolasetron Oral, Intravenous

Dolasetron Oral, Intravenous brand name
Dolasetron Oral, Intravenous dosage
Dolasetron Oral, Intravenous dosage forms
Dolasetron Oral, Intravenous injection
Dolasetron Oral, Intravenous side effects
Dolasetron Oral, Intravenous serious side effects

Commonly used brand name(s)

In the U.S.

Anzemet

Available Dosage Forms:

Solution

Therapeutic Class: Antiemetic

Pharmacologic Class: Dolasetron

Before Using dolasetron

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For dolasetron, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to dolasetron or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of dolasetron injection to prevent and treat nausea and vomiting that occurred after surgery in children 2 years of age and older. However, safety and efficacy have not been established in children younger than 2 years of age.

Use of dolasetron injection to prevent nausea and vomiting caused by cancer medicines in children is not recommended.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of dolasetron injection in the elderly. However, elderly patients are more likely to have heart rhythm problems (eg, prolonged QT, PR, and QRS interval), which may require caution and an adjustment in the dose for patients receiving dolasetron injection.

Use of dolasetron injection to prevent nausea and vomiting caused by cancer medicines in geriatric patients is not recommended.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	B	Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving dolasetron, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using dolasetron with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Amifampridine
Amisulpride
Apomorphine
Bepridil
Cisapride
Dronedarone
Levomethadyl
Mesoridazine
Pimozide
Piperaquine
Saquinavir
Sparfloxacin
Terfenadine
Thioridazine
Ziprasidone

Using dolasetron with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Acecainide
Ajmaline
Alfentanil
Alfuzosin
Almotriptan
Amineptine
Amiodarone
Amitriptyline
Amitriptylinoxide
Amoxapine
Amphetamine
Anagrelide
Aprindine
Aripiprazole
Aripiprazole Lauroxil
Arsenic Trioxide
Asenapine
Astemizole
Azimilide
Azithromycin
Benzphetamine
Bretylium
Brompheniramine
Buprenorphine
Buserelin
Buspirone
Butorphanol
Carbamazepine
Chloral Hydrate
Chloroquine
Chlorpheniramine
Chlorpromazine
Ciprofloxacin
Citalopram
Clarithromycin
Clomipramine
Clozapine
Cocaine
Codeine
Crizotinib
Cyclobenzaprine
Dabrafenib
Dasatinib
Degarelix
Delamanid
Desipramine
Deslorelin
Desvenlafaxine
Deutetrabenazine
Dextroamphetamine
Dextromethorphan
Dibenzepin
Dihydrocodeine
Disopyramide
Dofetilide
Domperidone
Donepezil
Doxepin
Droperidol
Duloxetine
Efavirenz
Eletriptan
Enflurane
Erythromycin
Escitalopram
Fentanyl
Fingolimod
Flecainide
Fluconazole
Fluoxetine
Fluvoxamine
Foscarnet
Frovatriptan
Furazolidone
Gatifloxacin
Gemifloxacin
Gonadorelin
Goserelin
Granisetron
Halofantrine
Haloperidol
Halothane
Histrelin
Hydrocodone
Hydromorphone
Hydroquinidine
Hydroxychloroquine
Hydroxytryptophan
Hydroxyzine
Ibutilide
Iloperidone
Imipramine
Iproniazid
Isocarboxazid
Isoflurane
Isradipine
Ivabradine
Ketoconazole
Lacosamide
Lapatinib
Leuprolide
Levofloxacin
Levomilnacipran
Levorphanol
Lidoflazine
Linezolid
Lisdexamfetamine
Lithium
Lofepramine
Lopinavir
Lorcainide
Lorcaserin
Lumefantrine
Mefloquine
Melitracen
Meperidine
Methadone
Methamphetamine
Methylene Blue
Metronidazole
Mifepristone
Milnacipran
Mirtazapine
Moclobemide
Morphine
Morphine Sulfate Liposome
Moxifloxacin
Nafarelin
Nalbuphine
Naratriptan
Nefazodone
Nilotinib
Norfloxacin
Nortriptyline
Octreotide
Ofloxacin
Ondansetron
Opipramol
Oxycodone
Oxymorphone
Paliperidone
Panobinostat
Paroxetine
Pasireotide
Pazopanib
Pentamidine
Pentazocine
Phenelzine
Pimavanserin
Pirmenol
Pitolisant
Posaconazole
Prajmaline
Probucol
Procainamide
Procarbazine
Prochlorperazine
Promethazine
Propafenone
Protriptyline
Quetiapine
Quinidine
Quinine
Ranolazine
Rasagiline
Remifentanil
Ribociclib
Risperidone
Rizatriptan
Salmeterol
Selegiline
Sematilide
Sertindole
Sertraline
Sevoflurane
Sibutramine
Sodium Phosphate
Sodium Phosphate, Dibasic
Sodium Phosphate, Monobasic
Solifenacin
Sorafenib
Sotalol
Spiramycin
St John's Wort
Sufentanil
Sulfamethoxazole
Sulpiride
Sultopride
Sumatriptan
Sunitinib
Tacrolimus
Tapentadol
Tedisamil
Telavancin
Telithromycin
Tetrabenazine
Tianeptine
Toremifene
Tramadol
Tranylcypromine
Trazodone
Trifluoperazine
Trimethoprim
Trimipramine
Triptorelin
Tryptophan
Vandetanib
Vardenafil
Vemurafenib
Venlafaxine
Vilazodone
Vinflunine
Voriconazole
Vortioxetine
Zolmitriptan
Zotepine
Zuclopenthixol

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Proper Use of dolasetron

A nurse or other trained health professional will give you dolasetron in a hospital. dolasetron is given through a needle placed in one of your veins.

dolasetron is usually given 15 minutes before anesthesia (medicine to put you to sleep before surgery) or right after surgery if nausea and vomiting begin.

Dolasteron injection may be mixed into apple or apple-grape juice and be given orally for children 2 years of age and older. The mixed medicine may be stored up to 2 hours at room temperature before use.

Precautions While Using dolasetron

Check with your doctor if severe nausea and vomiting continue after leaving the hospital.

dolasetron can cause changes in heart rhythms, such as conditions called QT, PR, and QRS prolongation. It may change the way your heart beats and cause fainting or serious side effects in some patients. Contact your doctor right away if you have any symptoms of heart rhythm problems, such as fast, pounding, or irregular heartbeats.

Dolasetron may cause a serious condition called serotonin syndrome if taken together with some medicines, such as fentanyl (Abstral®, Duragesic®), lithium (Eskalith®, Lithobid®), a MAO inhibitor (such as methylene blue injection, Eldepryl®, Marplan®, Nardil®, Parnate®), medicines to treat migraine headaches, or medicine to treat depression (eg, fluoxetine, mirtazapine, paroxetine, Celexa®, Effexor®, Lexapro®, Paxil®, Zoloft®). Check with your doctor first before taking any other medicines with dolasetron.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

dolasetron Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Less common or rare

Agitation
blurred vision
burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
chest pain or discomfort
chills
cold sweats
confusion
cough
delirium
diarrhea
difficulty with swallowing
dizziness
dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
fainting
fast, slow, or irregular heartbeat
feeling of warmth
feeling uncoordinated
hallucinations
hives, itching, or skin rash
lightheadedness
puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
redness of the face, neck, arms, and occasionally, upper chest
rigid muscles
sweating
tightness in the chest
tremor
unusual tiredness or weakness
vomiting

Incidence not known

Fast, pounding, or irregular heartbeat or pulse
no blood pressure or pulse
stopping of heart
unconsciousness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Headache