Depen Titratabs

• Tell all of your health care providers that you take this medicine. This includes your doctors, nurses, pharmacists, and dentists.
• Have blood work checked as you have been told by the doctor. Talk with the doctor.
• Have your urine checked as you have been told by your doctor.
• Take vitamin B6 (pyridoxine) as you were told by your doctor.
• Follow the diet and workout plan that your doctor told you about.
• You may have more chance of getting an infection. Wash hands often. Stay away from people with infections, colds, or flu.
• This medicine may lower the ability of your bone marrow to make blood cells that your body needs. This can lead to needing a blood transfusion and very bad and sometimes deadly bleeding problems or infections. Tell your doctor right away if you have signs of infection like fever, chills, or sore throat; any bruising or bleeding; or if you feel very tired or weak.
• You may bleed more easily. Be careful and avoid injury. Use a soft toothbrush and an electric razor.
• Deaths from certain diseases like aplastic anemia, Goodpasture's syndrome, and myasthenia gravis have happened with this medicine (Depen Titratabs). Talk with your doctor.
• Take good care of your teeth. See a dentist often.
• If you are 65 or older, use this medicine with care. You could have more side effects.
• Use birth control that you can trust to prevent pregnancy while taking this medicine (Depen Titratabs).
• This medicine may cause harm to the unborn baby if you take it while you are pregnant.
• If you are a woman and you miss a period, have unprotected sex, or think that your birth control has not worked, call your doctor right away.
• Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using this medicine while you are pregnant.

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

• Upset stomach or throwing up.
• Loose stools (diarrhea).
• Change in taste.
• Not hungry.
• Belly pain.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

• Store at room temperature.
• Store in a dry place. Do not store in a bathroom.
• Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
• Check with your pharmacist about how to throw out unused drugs.

Common side effects of Depen Titratabs include: cheilosis, epigastric pain, glossitis, oral mucosa ulcer, ageusia, and dysgeusia. Other side effects include: thrombocytopenia. See below for a comprehensive list of adverse effects.

-Initial dose: 125 or 250 mg orally once a day
-Titration: Increase at 1 to 3 month intervals by 125 or 250 mg per day, as response and tolerance indicate
-Maintenance dose: Should be individualized, and may require adjustment during the course of treatment; many patients respond satisfactorily to a dosage within the 500 to 750 mg per day range; changes in maintenance dosage levels may not be reflected clinically or in the erythrocyte sedimentation rate for 2 to 3 months after each dosage adjustment
-Maximum dose: If there is no discernible improvement after 3 to 4 months of therapy with 1 to 1.5 g per day, therapy should be discontinued

Comments:
-This drug should be taken on an empty stomach, 1 hour before or 2 hours after a meal.
-The total daily dose should be divided into 4 equal doses; if 4 equal doses are not feasible, the larger portion should be given at bedtime.
-The first evidence of a clinical response to this drug in rheumatoid arthritis patients may take 2 to 3 months.
-When therapy has been interrupted because of adverse reactions or other reasons, the drug should be reintroduced cautiously by starting with a lower dosage and increasing slowly.
-During the course of treatment some patients may experience an exacerbation of disease activity following an initial good response; these may be self-limited and can subside within 12 weeks. They are usually controlled by the addition of nonsteroidal anti-inflammatory drugs, and only if the patient has demonstrated a true "escape" phenomenon (as evidenced by failure of the flare to subside within this time period) should an increase in the maintenance dose ordinarily be considered.
-In the rheumatoid patient, migratory polyarthralgia due to this drug is extremely difficult to differentiate from an exacerbation of the rheumatoid arthritis. A substantial reduction in dosage or discontinuing therapy for up to several weeks will usually determine which of these processes is responsible for the arthralgia.

Use: Rheumatoid arthritis

Less than 18 years of age:
Usual dose: 30 mg/kg/day orally

Comments:
-This drug should be taken on an empty stomach, 1 hour before or 2 hours after a meal.
-The total daily dose should be divided into 4 equal doses; if 4 equal doses are not feasible, the larger portion should be given at bedtime.
-Patients should drink copious amounts of fluid.

Use: Cystinuria

Data not available

Data not available