Deplin

Deplin comes in tablets or capsules of 7.5 milligrams (mg) and 15 mg, to be taken once a day.

It doesn't matter whether you take Deplin with or without food, but try to be consistent in taking it as close to the same time every day as possible.

Deplin Overdose

To date, there have been no reports of anyone overdosing on Deplin.

Deplin — like all B-vitamins — is a water-soluble vitamin.

This means that the body will not store excess or unused amounts of Deplin in its tissues, and any extra Deplin will come out in your urine.

However, if you suspect an overdose, contact a poison control center or emergency room immediately.

You can get in touch with a poison control center at 800-222-1222.

Missed Dose of Deplin

If you miss a dose of Deplin, try to take it as soon as you remember.

However, if it's almost time for your next dose, skip the missed dose and continue on your regular dosing schedule.

Don't take extra doses to make up for a missed one.

Frequency Not Defined

Altered sleep patterns

Difficulty concentrating

Irritability

Overactivity

Excitement

Confusion

Impaired judgment

Anorexia

Nausea

Abdominal

Distention

Flatulence

Bitter or bad taste

Peak Plasma Time: 1 hr

Metabolism: Liver

Excretion: feces (traces), urine (90%)

Mechanism of Action

L-methylfolate is the primary biologically active isomer of folic acid and the primary form of folate in circulation

Folic acid is a precursor of tetrahydrofolic acid, which is involved as a cofactor for transformylation reactions

These reactions are involved in the biosynthesis of thymidylates and purines of nucleic acids

The mechanism as an adjunct therapy in depression is unknown

Folate is a form of B vitamin that occurs naturally in many foods. Folic acid is the man-made form of folate that is added to processed foods or vitamin and mineral supplements. Folate is needed in the human body for production of red blood cells.

A lack (deficiency) of folate in the human body can be caused by certain diseases, by taking certain medications, or by not getting enough folate in your diet. Folate deficiency can lead to decreased red blood cells, or anemia. Folate deficiency can also cause high levels of a certain amino acid in the blood, a condition called hyperhomocysteinemia (HYE-per-HOE-moe-sis-tin-EE-mee-a).

L-methylfolate is a medical food for use in people who have conditions related to folate deficiency. L-methylfolate is also used in people with major depressive disorder who have folate deficiency, or in people with schizophrenia who have hyperhomocysteinemia related to folate deficiency.

L-methylfolate is not an antidepressant or anti-psychotic medication. However, l-methylfolate may enhance the effects of antidepressant medications.

L-methylfolate may also be used for purposes not listed in this medication guide.

You should not use l-methylfolate if you are allergic to it.

To make sure l-methylfolate is safe for you, tell your doctor if you have:

• seizures or epilepsy;

• a history of vitamin B12 deficiency or pernicious anemia; or

• a history of bipolar disorder (manic depression).

Tell your doctor if you are pregnant or breast-feeding. Your dose needs may be different during pregnancy or while you are nursing.

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Less serious side effects may occur, and you may have none at all.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
• A burning or tingling feeling that is not normal.

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

• Upset stomach or throwing up.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.