DDAVP injection
Name: DDAVP injection
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What should I discuss with my healthcare provider before using injectable DDAVP (desmopressin injection)?
You should not use this medicine if you are allergic to desmopressin, or if you have:
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severe kidney disease; or
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if you have ever had hyponatremia (low sodium levels in your body).
To make sure desmopressin is safe for you, tell your doctor if you have:
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an electrolyte imbalance;
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a psychologic disorder that causes extreme or unusual thirst;
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fluid retention;
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congestive heart failure, coronary artery disease;
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high or low blood pressure;
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urination problems;
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kidney disease;
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cystic fibrosis;
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a head injury or brain tumor; or
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a history of blood clots, stroke, or heart attack.
It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
It is not known whether desmopressin passes into breast milk or if it could affect the nursing baby. Tell your doctor if you are breast-feeding.
What happens if I miss a dose?
Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.
What should I avoid while using DDAVP (desmopressin injection)?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
Uses For DDAVP
Desmopressin injection is used to treat bleeding in patients with hemophilia A or von Willebrand disease (Type I). It is also used to treat central cranial diabetes insipidus. This is a condition that causes the body to lose too much fluid and become dehydrated. Desmopressin injection is used to control frequent urination and increased thirst caused by certain types of brain injury or brain surgery.
Desmopressin is similar to a hormone that is produced in the body. It acts on the kidneys to reduce the flow of urine. For bleeding, desmopressin increases the blood levels of factor VIII and von Willebrand factor. This results in less bleeding for patients who have low levels of these agents.
This medicine is available only with your doctor's prescription.
Before Using DDAVP
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of desmopressin injection in children. However, the safety and efficacy of desmopressin injection have not been established for children younger than 12 years of age with diabetes insipidus, and for children younger than 3 months of age with hemophilia A or von Willebrand disease.
Geriatric
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of desmopressin injection in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require caution and an adjustment in the dose for patients receiving desmopressin.
Pregnancy
Pregnancy Category | Explanation | |
---|---|---|
All Trimesters | B | Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus. |
Breast Feeding
Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.
Interactions with Medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Aceclofenac
- Acemetacin
- Alfentanil
- Amineptine
- Amitriptyline
- Amitriptylinoxide
- Amoxapine
- Amtolmetin Guacil
- Anileridine
- Aspirin
- Bromfenac
- Bufexamac
- Buprenorphine
- Butorphanol
- Carbamazepine
- Celecoxib
- Chlorpromazine
- Choline Salicylate
- Citalopram
- Clomipramine
- Clonixin
- Codeine
- Desipramine
- Dexibuprofen
- Dexketoprofen
- Dezocine
- Diacetylmorphine
- Dibenzepin
- Diclofenac
- Difenoxin
- Diflunisal
- Dihydrocodeine
- Diphenoxylate
- Dipyrone
- Doxepin
- Droxicam
- Escitalopram
- Ethylmorphine
- Etodolac
- Etofenamate
- Etoricoxib
- Felbinac
- Fenoprofen
- Fentanyl
- Fepradinol
- Feprazone
- Floctafenine
- Flufenamic Acid
- Fluoxetine
- Flurbiprofen
- Fluvoxamine
- Hydrocodone
- Hydromorphone
- Ibuprofen
- Imipramine
- Indomethacin
- Ketobemidone
- Ketoprofen
- Ketorolac
- Lamotrigine
- Levorphanol
- Lofepramine
- Lornoxicam
- Loxoprofen
- Lumiracoxib
- Meclofenamate
- Mefenamic Acid
- Melitracen
- Meloxicam
- Meperidine
- Meptazinol
- Methadone
- Morniflumate
- Morphine
- Morphine Sulfate Liposome
- Nabumetone
- Nalbuphine
- Naproxen
- Nepafenac
- Nicomorphine
- Niflumic Acid
- Nimesulide
- Nimesulide Beta Cyclodextrin
- Nortriptyline
- Opipramol
- Opium
- Opium Alkaloids
- Oxaprozin
- Oxycodone
- Oxymorphone
- Oxyphenbutazone
- Papaveretum
- Parecoxib
- Paregoric
- Paroxetine
- Pentazocine
- Phenylbutazone
- Piketoprofen
- Piritramide
- Piroxicam
- Pranoprofen
- Proglumetacin
- Propyphenazone
- Proquazone
- Protriptyline
- Remifentanil
- Rofecoxib
- Salicylic Acid
- Salsalate
- Sertraline
- Sodium Salicylate
- Sufentanil
- Sulindac
- Tapentadol
- Tenoxicam
- Tianeptine
- Tiaprofenic Acid
- Tilidine
- Tolfenamic Acid
- Tolmetin
- Tramadol
- Trimipramine
- Valdecoxib
- Vilazodone
- Vortioxetine
Interactions with Food/Tobacco/Alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
- Blood clotting problems or
- Hypertension (high blood pressure) or
- Hypotension (low blood pressure) or
- Tachycardia (increased heart rate)—Use with caution. May make these conditions worse.
- Coronary artery disease or
- Cystic fibrosis or
- Heart failure or
- Kidney problems or
- Polydipsia (excessive thirst), habitual or psychogenic—Use with caution. May cause side effects to become worse.
- Hyponatremia (low sodium in the blood), or history of or
- Kidney disease, moderate to severe or
- Type IIB von Willebrand disease—Should not be used in patients with these conditions.
Overdose
If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: confusion, drowsiness, persistent/severe headache, sudden weight gain.
Notes
Do not share this medication with others.
Laboratory and/or medical tests (such as urine tests, blood tests, blood pressure, pulse) may be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.
Missed Dose
If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.
Storage
Store this medication in the refrigerator between 36-46 degrees F (2-8 degrees C). Do not freeze. Keep all medicines away from children and pets.
Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.Information last revised December 2016. Copyright(c) 2016 First Databank, Inc.