DDAVP nasal

Name: DDAVP nasal

What should I discuss with my healthcare provider before using DDAVP (desmopressin nasal)?

You should not use this medicine if you are allergic to desmopressin.

Depending on your condition, you may not be able to use desmopressin nasal if:

  • you have ever had hyponatremia (low sodium levels in your body);

  • you have uncontrolled high blood pressure;

  • you have severe heart failure;

  • you have severe kidney disease;

  • you have SIADH (syndrome of inappropriate antidiuretic hormone secretion (SIADH); or

  • you have an illness or condition that causes excessive thirst, dehydration, or an electrolyte imbalance.

Some medicines can cause unwanted or dangerous effects when used with desmopressin. Your doctor may need to change your treatment plan if you use any of the following drugs:

  • a "loop" diuretic--bumetanide, ethacrynic acid, furosemide, torsemide; or

  • an inhaled steroid--beclomethasone, budesonide, ciclesonide, flunisolide, fluticasone, mometasone, Arnuity Ellipta, Asmanex, Flovent, Pulmicort, Qvar, and others.

To make sure desmopressin nasal is safe for you, tell your doctor if you have:

  • an electrolyte imbalance;

  • a psychologic disorder that causes extreme or unusual thirst;

  • fluid retention;

  • congestive heart failure, coronary artery disease;

  • urination problems;

  • kidney disease;

  • an infection or illness with fever, vomiting, or diarrhea;

  • cystic fibrosis;

  • a head injury or brain tumor;

  • nasal problems such as a runny or stuffy nose;

  • diabetes; or

  • a history of blood clots, stroke, or heart attack.

Desmopressin nasal may be less effective if you have any swelling or scarring inside your nose, or any nasal or sinus problems (such as deviated septum).

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. Desmopressin nasal should not be used to treat excessive urination that is a normal condition of pregnancy.

Desmopressin nasal can pass into breast milk, but effects on the nursing baby are not known. Tell your doctor if you are breast-feeding.

Do not give this medicine to a child without medical advice. Stimate is not approved for use by anyone younger than 11 years old. The use of Noctiva has not been studied in anyone younger than 50 years old.

What happens if I miss a dose?

Use the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include headache, confusion, drowsiness, rapid weight gain, or urination problems.

What other drugs will affect DDAVP (desmopressin nasal)?

Tell your doctor about all your current medicines and any you start or stop using, especially:

  • any other nasal medicine;

  • an antidepressant;

  • bladder or urinary medicines;

  • cold or allergy medicine;

  • a diuretic or "water pill";

  • heart or blood pressure medication;

  • medicine to treat anxiety, mood disorders, bipolar disorder, or schizophrenia;

  • a steroid medicine;

  • seizure medicine--carbamazepine, lamotrigine; or

  • NSAIDs (nonsteroidal anti-inflammatory drugs)--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.

This list is not complete. Other drugs may interact with desmopressin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.


Desmopressin is used to control the amount of urine your kidneys make. Normally, the amount of urine you make is controlled by a certain substance in the body called vasopressin. In people who have "water diabetes" (diabetes insipidus) or certain kinds of head injury or brain surgery, the body does not make enough vasopressin. Desmopressin is a man-made form of vasopressin and is used to replace a low level of vasopressin. This medication helps to control increased thirst and too much urination due to these conditions, and helps prevent dehydration.

Desmopressin products applied in the nose are no longer indicated to control nighttime bedwetting in children because of the increased risk of developing a serious side effect (a low level of sodium in the blood).

How to use DDAVP Solution, Non-

Read the Patient Information Leaflet and instructions that come with your product. If you have any questions, consult your doctor or pharmacist.

Give this medication through the nose, usually 1 to 3 times a day as directed by your doctor. Use the marked tube that comes with your medication. Place your prescribed dose into the tube. Deliver the solution into your nose as directed. Wash the tube with water after use, and shake it until it is completely dry.

If a child is using this medication, a parent or other responsible adult should supervise and help the child use this medication properly.

Limit drinking of water and other fluids while using this medication, especially in children and older adults. Consult your doctor for details. If you find that you are drinking more fluids than directed, tell your doctor right away. Your treatment will need to be adjusted. (See also Side Effects and Precautions sections.)

Dosage is based on your medical condition and response to treatment. Do not use more desmopressin or use it more often than prescribed.

Use this medication regularly to get the most benefit from it. To help you remember, use it at the same time(s) each day.

Tell your doctor if your condition does not improve or if this medication stops working well.


Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Other medications besides desmopressin may also affect the balance of water and sodium in your body. Therefore, tell your doctor or pharmacist about all the products you take, including: nonsteroidal anti-inflammatory drugs (NSAIDs such as ibuprofen, naproxen), psychiatric medicines (such as chlorpromazine), SSRI antidepressants (such as sertraline), tolvaptan, tricyclic antidepressants (such as amitriptyline), "water pills" (diuretics such as furosemide).