DDAVP (Desmopressin Nasal Spray (Diabetes Insipidus))

• Tell all of your health care providers that you take this medicine. This includes your doctors, nurses, pharmacists, and dentists.
• Very bad allergic reactions have rarely happened. Sometimes, allergic reactions have been deadly with the shot form of DDAVP. Talk with the doctor.
• Use with care in children. Talk with the doctor.
• Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using this medicine while you are pregnant.
• Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

• Some brands of DDAVP need to be stored in a refrigerator. Some brands of this medicine need to be stored at room temperature. If you have questions about how to store DDAVP, talk with your pharmacist.
• Be sure you know how long you can store this medicine before you need to throw it away.
• Store upright with the cap on.
• Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
• Check with your pharmacist about how to throw out unused drugs.

More frequently reported side effects include: headache. See below for a comprehensive list of adverse effects.

Applies to desmopressin: oral tablet

Other dosage forms:

• injection solution
• nasal solution, nasal spray

Along with its needed effects, desmopressin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking desmopressin:

• Confusion
• convulsions
• decreased urine output
• dizziness
• fast or irregular heartbeat
• headache
• increased thirst
• muscle pain or cramps
• nausea or vomiting
• shortness of breath
• swelling of the face, ankles, or hands
• unusual tiredness or weakness

• Weight gain

Some side effects of desmopressin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Delusions
• dementia
• diarrhea

Infants 3 months of age and children:
IV: 0.3 mcg/kg by slow infusion over 15 to 30 minutes beginning 30 minutes before procedure. May repeat dose if needed.

Children more than 12 years of age:
IV: 0.3 mcg/kg once slowly over 15 to 30 minutes.
Intranasal:
50 kg or less: 150 mcg
More than 50 kg: 150 mcg in each nostril.
Demonstration of an adequate improvement in coagulation profile after administration is recommended prior to any surgical procedures. Preoperative doses may be given 2 hours prior to the scheduled procedure. Repeat administration should be determined by laboratory response and clinical condition of the patient. The nasal spray should not be used to treat patients with type IIB von Willebrand's disease since platelet aggregation may be induced.

Desmopressin is contraindicated in patients with moderate to severe renal impairment (defined as a creatinine clearance below 50 mL/min).

Data not available

The comparable antidiuretic dose of the injection is approximately 1/10 the intranasal dose.